Spotlight on Molecular Profiling:

In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation

Ogechi N. Ikediobi, Mark Reimers, Steffen Durinck, Paul E. Blower, Andrew P. Futreal, Michael R. Stratton, and John N. Weinstein
Mol Cancer Ther 2008 7: 1337-1346Published Online First June 4, 2008. doi: 10.1158/1535-7163.MCT-07-2308 [Abstract] [Full Text] [PDF] Supplementary Material  

Review:

Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

Jorge A. Garcia and David Danielpour
Mol Cancer Ther 2008 7: 1347-1354 doi: 10.1158/1535-7163.MCT-07-2408 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

Zhenwen Yan, Huafei Zou, Fang Tian, Jennifer R. Grandis, A. James Mixson, Patrick Y. Lu, and Lu-Yuan Li
Mol Cancer Ther 2008 7: 1355-1364Published Online First June 4, 2008. doi: 10.1158/1535-7163.MCT-08-0104 [Abstract] [Full Text] [PDF] Supplementary Material  

Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBP

Cheng-Chung Wu, Jau-Chen Lin, Shuenn-Chen Yang, Chiu-Wen Lin, Jeremy J.W. Chen, Jin-Yuan Shih, Tse-Ming Hong, and Pan-Chyr Yang
Mol Cancer Ther 2008 7: 1365-1375Published Online First June 4, 2008. doi: 10.1158/1535-7163.MCT-08-0091 [Abstract] [Full Text] [PDF] Supplementary Material  

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

Yun-Ju Chen, Meng-Ru Shen, Yen-Jen Chen, Ming-Chei Maa, and Tzeng-Horng Leu
Mol Cancer Ther 2008 7: 1376-1385 doi: 10.1158/1535-7163.MCT-07-2388 [Abstract] [Full Text] [PDF] Supplementary Material  

-Catenin overrides Src-dependent activation of β-catenin oncogenic signaling

Landon J. Inge, Sigrid A. Rajasekaran, Daniel Wolle, Sonali P. Barwe, Sergey Ryazantsev, Charles M. Ewing, William B. Isaacs, and Ayyappan K. Rajasekaran
Mol Cancer Ther 2008 7: 1386-1397 doi: 10.1158/1535-7163.MCT-07-2029 [Abstract] [Full Text] [PDF]  

Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes

Lulzim Shkreta, Ulrike Froehlich, Éric R. Paquet, Johanne Toutant, Sherif Abou Elela, and Benoit Chabot
Mol Cancer Ther 2008 7: 1398-1409 doi: 10.1158/1535-7163.MCT-08-0192 [Abstract] [Full Text] [PDF] Supplementary Material  

Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells

Michela Muscolini, Roberta Cianfrocca, Angela Sajeva, Simona Mozzetti, Gabriella Ferrandina, Antonio Costanzo, and Loretta Tuosto
Mol Cancer Ther 2008 7: 1410-1419 doi: 10.1158/1535-7163.MCT-08-0299 [Abstract] [Full Text] [PDF]  

Recombinant, refolded tetrameric p53 and gonadotropin-releasing hormone-p53 slow proliferation and induce apoptosis in p53-deficient cancer cells

Michelle LaFevre-Bernt, Shili Wu, and Xinli Lin
Mol Cancer Ther 2008 7: 1420-1429 doi: 10.1158/1535-7163.MCT-08-0078 [Abstract] [Full Text] [PDF] Supplementary Material  

ISG15 as a novel tumor biomarker for drug sensitivity

Shyamal D. Desai, Laurence M. Wood, Yu-Chen Tsai, Tao-Shih Hsieh, Jeffrey R. Marks, Georgia L. Scott, Beppino C. Giovanella, and Leroy F. Liu
Mol Cancer Ther 2008 7: 1430-1439 doi: 10.1158/1535-7163.MCT-07-2345 [Abstract] [Full Text] [PDF]  

Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins

Min Huang, Ze-Hong Miao, Hong Zhu, Yu-Jun Cai, Wei Lu, and Jian Ding
Mol Cancer Ther 2008 7: 1440-1449 doi: 10.1158/1535-7163.MCT-07-2116 [Abstract] [Full Text] [PDF] Supplementary Material  

Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma

Ganapati V. Hegde, Corey M. Munger, Katy Emanuel, Avadhut D. Joshi, Timothy C. Greiner, Dennis D. Weisenburger, Julie M. Vose, and Shantaram S. Joshi
Mol Cancer Ther 2008 7: 1450-1460Published Online First June 4, 2008. doi: 10.1158/1535-7163.MCT-07-2118 [Abstract] [Full Text] [PDF] Supplementary Material  

Potent synergy of dual antitumor peptides for growth suppression of human glioblastoma cell lines

Eisaku Kondo, Takehiro Tanaka, Takayoshi Miyake, Tomotsugu Ichikawa, Masahiko Hirai, Masaki Adachi, Kazuhiro Yoshikawa, Koichi Ichimura, Nobuya Ohara, Akiyoshi Moriwaki, Isao Date, Ryuzo Ueda, and Tadashi Yoshino
Mol Cancer Ther 2008 7: 1461-1471 doi: 10.1158/1535-7163.MCT-07-2010 [Abstract] [Full Text] [PDF] Supplementary Material  

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198

Theresa M. LaVallee, Patricia A. Burke, Glenn M. Swartz, Ernest Hamel, Gregory E. Agoston, Jamshed Shah, Lita Suwandi, Art D. Hanson, William E. Fogler, Carolyn F. Sidor, and Anthony M. Treston
Mol Cancer Ther 2008 7: 1472-1482 doi: 10.1158/1535-7163.MCT-08-0107 [Abstract] [Full Text] [PDF]  

Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas

Wenhua Piao, Yu Wang, Yasushi Adachi, Hiroyuki Yamamoto, Rong Li, Arisa Imsumran, Hua Li, Tadateru Maehata, Masanori Ii, Yoshiaki Arimura, Choon-Taek Lee, Yasuhisa Shinomura, David P. Carbone, and Kohzoh Imai
Mol Cancer Ther 2008 7: 1483-1493 doi: 10.1158/1535-7163.MCT-07-2395 [Abstract] [Full Text] [PDF]  

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling

Rentian Feng, Huihui Ma, Christian A. Hassig, Joseph E. Payne, Nicholas D. Smith, Markus Y. Mapara, Jeffrey H. Hager, and Suzanne Lentzsch
Mol Cancer Ther 2008 7: 1494-1505 doi: 10.1158/1535-7163.MCT-08-0183 [Abstract] [Full Text] [PDF]  

Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines

Medhi Wangpaichitr, Niramol Savaraj, Johnathan Maher, Metin Kurtoglu, and Theodore J. Lampidis
Mol Cancer Ther 2008 7: 1506-1513 doi: 10.1158/1535-7163.MCT-07-2334 [Abstract] [Full Text] [PDF] Supplementary Material  

Antitumor effect of a transducible fusogenic peptide releasing multiple proapoptotic peptides by caspase-3

Mi-Kyung Kwon, Ju-Ock Nam, Rang-Woon Park, Byung-Heon Lee, Jae-Yong Park, Young-Ro Byun, Sang-Yoon Kim, Ick-Chan Kwon, and In-San Kim
Mol Cancer Ther 2008 7: 1514-1522 doi: 10.1158/1535-7163.MCT-07-2009 [Abstract] [Full Text] [PDF]  

17-Acetoxyjolkinolide B irreversibly inhibits IB kinase and induces apoptosis of tumor cells

Shou-Sheng Yan, Ying Li, Ying Wang, Shen-Si Shen, Yuan Gu, Hong-Bing Wang, Guo-Wei Qin, and Qiang Yu
Mol Cancer Ther 2008 7: 1523-1532 doi: 10.1158/1535-7163.MCT-08-0263 [Abstract] [Full Text] [PDF]  

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

Sanjeev Shangary, Ke Ding, Su Qiu, Zaneta Nikolovska-Coleska, Joshua A. Bauer, Meilan Liu, Guoping Wang, Yipin Lu, Donna McEachern, Denzil Bernard, Carol R. Bradford, Thomas E. Carey, and Shaomeng Wang
Mol Cancer Ther 2008 7: 1533-1542 doi: 10.1158/1535-7163.MCT-08-0140 [Abstract] [Full Text] [PDF] Supplementary Material  

STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends

H. Dan Lewis, Ashley Winter, Thomas F. Murphy, Snehlata Tripathi, Virendra N. Pandey, and Beverly E. Barton
Mol Cancer Ther 2008 7: 1543-1550 doi: 10.1158/1535-7163.MCT-08-0154 [Abstract] [Full Text] [PDF]  

Fasudil-induced hypoxia-inducible factor-1 degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells

Keiko Takata, Ken-ichirou Morishige, Toshifumi Takahashi, Kae Hashimoto, Seiji Tsutsumi, Limei Yin, Tsuyoshi Ohta, Jun Kawagoe, Kazuhiro Takahashi, and Hirohisa Kurachi
Mol Cancer Ther 2008 7: 1551-1561 doi: 10.1158/1535-7163.MCT-07-0428 [Abstract] [Full Text] [PDF]  

Generation of adenovirus-mediated anti-CD20 antibody and its effect on B-cell deletion in mice and nonhuman primate cynomolgus monkey

Jie Chen, Changqing Su, Qiujun Lu, Wenfang Shi, Qi Zhang, Xinghua Wang, Ju Long, Qin Yang, Linfang Li, Xiaoyuan Jia, Jianming Wang, Wanming Da, Xinyuan Liu, Mengchao Wu, and Qijun Qian
Mol Cancer Ther 2008 7: 1562-1568Published Online First June 4, 2008. doi: 10.1158/1535-7163.MCT-08-0297 [Abstract] [Full Text] [PDF]  

Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo

Shoucheng Ning, Jeffrey A. Nemeth, Rebecca L. Hanson, Kevin Forsythe, and Susan J. Knox
Mol Cancer Ther 2008 7: 1569-1578 doi: 10.1158/1535-7163.MCT-08-0288 [Abstract] [Full Text] [PDF]  

Targeting IL-13R2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin

Mitomu Kioi, Saraswathy Seetharam, and Raj K. Puri
Mol Cancer Ther 2008 7: 1579-1587 doi: 10.1158/1535-7163.MCT-07-2131 [Abstract] [Full Text] [PDF]  

Human -defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice

Ning Xu, Yong-sheng Wang, Wu-bin Pan, Bo Xiao, Yan-jun Wen, Xian-cheng Chen, Li-juan Chen, Hong-xin Deng, Jia You, Bing Kan, A-fu Fu, Dan Li, Xia Zhao, and Yu-quan Wei
Mol Cancer Ther 2008 7: 1588-1597 doi: 10.1158/1535-7163.MCT-08-0010 [Abstract] [Full Text] [PDF]  

A novel triple-regulated oncolytic adenovirus carrying p53 gene exerts potent antitumor efficacy on common human solid cancers

Xinghua Wang, Changqing Su, Hui Cao, Kui Li, Jie Chen, Lixin Jiang, Qi Zhang, Xiaobing Wu, Xiaoyuan Jia, Yongjing Liu, Weiguo Wang, Xinyuan Liu, Mengchao Wu, and Qijun Qian
Mol Cancer Ther 2008 7: 1598-1603 doi: 10.1158/1535-7163.MCT-07-2429 [Abstract] [Full Text] [PDF]  

Pinitol targets nuclear factor-B activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis

Gautam Sethi, Kwang Seok Ahn, Bokyung Sung, and Bharat B. Aggarwal
Mol Cancer Ther 2008 7: 1604-1614 doi: 10.1158/1535-7163.MCT-07-2424 [Abstract] [Full Text] [PDF]  

DNA vaccination with CD44 variant isoform reduces mammary tumor local growth and lung metastasis

Shulamit Batya Wallach-Dayan, Ariel M. Rubinstein, Carla Hand, Raphael Breuer, and David Naor
Mol Cancer Ther 2008 7: 1615-1623 doi: 10.1158/1535-7163.MCT-07-2383 [Abstract] [Full Text] [PDF]  

Biodistribution and kinetics of the novel selective oncolytic adenovirus M1 after systemic administration

Xiaoyuan Huang, Liang Zhuang, Yang Cao, Qinglei Gao, Zhiqiang Han, Duozhuang Tang, Hui Xing, Wei Wang, Yunping Lu, Gang Xu, Shixuan Wang, Jianfeng Zhou, and Ding Ma
Mol Cancer Ther 2008 7: 1624-1632 doi: 10.1158/1535-7163.MCT-07-2134 [Abstract] [Full Text] [PDF]  

Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor–mediated transcription

Liang You, Zhidong Xu, Chandanamali Punchihewa, David M. Jablons, and Naoaki Fujii
Mol Cancer Ther 2008 7: 1633-1638 doi: 10.1158/1535-7163.MCT-08-0155 [Abstract] [Full Text] [PDF] Supplementary Material  

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

Dayong Zhai, Chaofang Jin, Chung-wai Shiau, Shinichi Kitada, Arnold C. Satterthwait, and John C. Reed
Mol Cancer Ther 2008 7: 1639-1646 doi: 10.1158/1535-7163.MCT-07-2373 [Abstract] [Full Text] [PDF] Supplementary Material  

Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells

Changyou Li, Rongxiu Li, Jennifer R. Grandis, and Daniel E. Johnson
Mol Cancer Ther 2008 7: 1647-1655 doi: 10.1158/1535-7163.MCT-07-2444 [Abstract] [Full Text] [PDF] Supplementary Material  

Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid

Sophie Domhan, Stefan Muschal, Christian Schwager, Christian Morath, Ute Wirkner, Wilhelm Ansorge, Christian Maercker, Martin Zeier, Peter E. Huber, and Amir Abdollahi
Mol Cancer Ther 2008 7: 1656-1668 doi: 10.1158/1535-7163.MCT-08-0193 [Abstract] [Full Text] [PDF] Supplementary Material  

Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor–induced angiogenesis

Patrick A. Singleton, Joe G.N. Garcia, and Jonathan Moss
Mol Cancer Ther 2008 7: 1669-1679 doi: 10.1158/1535-7163.MCT-07-2217 [Abstract] [Full Text] [PDF]  

Arsenic trioxide decreases AKT protein in a caspase-dependent manner

Koren K. Mann, Myrian Colombo, and Wilson H. Miller, Jr.
Mol Cancer Ther 2008 7: 1680-1687 doi: 10.1158/1535-7163.MCT-07-2164 [Abstract] [Full Text] [PDF] Supplementary Methods  

Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage

Yanyan Yan, Xiaodong Su, Yongju Liang, Jianye Zhang, Chengjun Shi, Yu Lu, Lianquan Gu, and Liwu Fu
Mol Cancer Ther 2008 7: 1688-1697 doi: 10.1158/1535-7163.MCT-07-2362 [Abstract] [Full Text] [PDF]  

Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase Cβ inhibitor, in non-small cell lung cancer cells

Floriana Morgillo, Erika Martinelli, Teresa Troiani, Gianluca Laus, Stefano Pepe, Cesare Gridelli, and Fortunato Ciardiello
Mol Cancer Ther 2008 7: 1698-1707 doi: 10.1158/1535-7163.MCT-07-0547 [Abstract] [Full Text] [PDF]  

Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer

Shadan Ali, Sanjeev Banerjee, Aamir Ahmad, Bassel F. El-Rayes, Philip A. Philip, and Fazlul H. Sarkar
Mol Cancer Ther 2008 7: 1708-1719 doi: 10.1158/1535-7163.MCT-08-0354 [Abstract] [Full Text] [PDF]  

5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy

Ludovic Bourré, Francesca Giuntini, Ian M. Eggleston, Michael Wilson, and Alexander J. MacRobert
Mol Cancer Ther 2008 7: 1720-1729 doi: 10.1158/1535-7163.MCT-08-0092 [Abstract] [Full Text] [PDF]  

In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy

Marites P. Melancon, Wei Lu, Zhi Yang, Rui Zhang, Zhi Cheng, Andrew M. Elliot, Jason Stafford, Tammy Olson, Jin Z. Zhang, and Chun Li
Mol Cancer Ther 2008 7: 1730-1739 doi: 10.1158/1535-7163.MCT-08-0016 [Abstract] [Full Text] [PDF]  

Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH₂ terminal kinase with opposing effects on cell survival

Anette Weyergang, Olav Kaalhus, and Kristian Berg
Mol Cancer Ther 2008 7: 1740-1750 doi: 10.1158/1535-7163.MCT-08-0020 [Abstract] [Full Text] [PDF]  

Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models

Shuzhen Liu, Hongwei Cheng, Wanda Kwan, Joanna M. Lubieniecka, and Torsten O. Nielsen
Mol Cancer Ther 2008 7: 1751-1761 doi: 10.1158/1535-7163.MCT-07-0560 [Abstract] [Full Text] [PDF]  

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