Spotlight on Clinical Response:

Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib

David Hong, Lei Ye, Robert Gagel, Lakshmi Chintala, Adel K. El Naggar, John Wright, and Razelle Kurzrock
Mol Cancer Ther 2008 7: 1001-1006Published Online First April 29, 2008. doi: 10.1158/1535-7163.MCT-07-2422 [Abstract] [Full Text] [PDF]  

Review:

Competitive or noncompetitive, that's the question: research toward histone deacetylase inhibitors

Hong Su, Lucia Altucci, and Qidong You
Mol Cancer Ther 2008 7: 1007-1012 doi: 10.1158/1535-7163.MCT-07-2289 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Improved grading and survival prediction of human astrocytic brain tumors by artificial neural network analysis of gene expression microarray data

Lawrence P. Petalidis, Anastasis Oulas, Magnus Backlund, Matthew T. Wayland, Lu Liu, Karen Plant, Lisa Happerfield, Tom C. Freeman, Panayiota Poirazi, and V. Peter Collins
Mol Cancer Ther 2008 7: 1013-1024Published Online First April 29, 2008. doi: 10.1158/1535-7163.MCT-07-0177 [Abstract] [Full Text] [PDF] Supplementary Material  

An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector

Guozheng Liu, Shuping Dou, Mary Rusckowski, and Donald J. Hnatowich
Mol Cancer Ther 2008 7: 1025-1032 doi: 10.1158/1535-7163.MCT-07-2203 [Abstract] [Full Text] [PDF]  

Combi-targeting concept: an optimized single-molecule dual-targeting model for the treatment of chronic myelogenous leukemia

Athanasia Katsoulas, Zakaria Rachid, James P. McNamee, Christopher Williams, and Bertrand J. Jean-Claude
Mol Cancer Ther 2008 7: 1033-1043 doi: 10.1158/1535-7163.MCT-07-0179 [Abstract] [Full Text] [PDF]  

Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein

Hui Wang, Kai Chen, Weibo Cai, Zibo Li, Lina He, Amir Kashefi, and Xiaoyuan Chen
Mol Cancer Ther 2008 7: 1044-1053 doi: 10.1158/1535-7163.MCT-07-2084 [Abstract] [Full Text] [PDF] Supplementary Material  

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

Christian A. Hassig, Kent T. Symons, Xin Guo, Phan-Manh Nguyen, Tami Annable, Paul L. Wash, Joseph E. Payne, David A. Jenkins, Céline Bonnefous, Carol Trotter, Yan Wang, John V. Anzola, Elena L. Milkova, Timothy Z. Hoffman, Sara J. Dozier, Brandon M. Wiley, Alan Saven, James W. Malecha, Robert L. Davis, Jerry Muhammad, Andrew K. Shiau, Stewart A. Noble, Tadimeti S. Rao, Nicholas D. Smith, and Jeffrey H. Hager
Mol Cancer Ther 2008 7: 1054-1065 doi: 10.1158/1535-7163.MCT-07-2347 [Abstract] [Full Text] [PDF] Supplementary Material  

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin

Andrea Newbold, Ralph K. Lindemann, Leonie A. Cluse, Kate F. Whitecross, Anthony E. Dear, and Ricky W. Johnstone
Mol Cancer Ther 2008 7: 1066-1079 doi: 10.1158/1535-7163.MCT-07-2256 [Abstract] [Full Text] [PDF] Supplementary Material  

Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor

Adriana S. Beltran, Xueguang Sun, Paul M. Lizardi, and Pilar Blancafort
Mol Cancer Ther 2008 7: 1080-1090 doi: 10.1158/1535-7163.MCT-07-0526 [Abstract] [Full Text] [PDF]  

Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region

Karthikeyan Kandasamy and Andrew S. Kraft
Mol Cancer Ther 2008 7: 1091-1100 doi: 10.1158/1535-7163.MCT-07-2368 [Abstract] [Full Text] [PDF] Supplementary Material  

Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells

Ningxi Zhu, Lubing Gu, Fengzhi Li, and Muxiang Zhou
Mol Cancer Ther 2008 7: 1101-1109 doi: 10.1158/1535-7163.MCT-08-0179 [Abstract] [Full Text] [PDF]  

Comparison of antitumor effects of multitargeted tyrosine kinase inhibitors in acute myelogenous leukemia

Shuiying Hu, Hongmei Niu, Patton Minkin, Shelley Orwick, Akira Shimada, Hiroto Inaba, Gary V.H. Dahl, Jeffrey Rubnitz, and Sharyn D. Baker
Mol Cancer Ther 2008 7: 1110-1120 doi: 10.1158/1535-7163.MCT-07-2218 [Abstract] [Full Text] [PDF] Supplementary Material  

Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells

Ellen Weisberg, Renee D. Wright, Douglas W. McMillin, Constantine Mitsiades, Arghya Ray, Rosemary Barrett, Sophia Adamia, Richard Stone, Ilene Galinsky, Andrew L. Kung, and James D. Griffin
Mol Cancer Ther 2008 7: 1121-1129Published Online First April 29, 2008. doi: 10.1158/1535-7163.MCT-07-2331 [Abstract] [Full Text] [PDF] Supplementary Material  

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

Ismael Samudio, Svitlana Kurinna, Peter Ruvolo, Borys Korchin, Hagop Kantarjian, Miloslav Beran, Kenneth Dunner, Jr., Seiji Kondo, Michael Andreeff, and Marina Konopleva
Mol Cancer Ther 2008 7: 1130-1139 doi: 10.1158/1535-7163.MCT-07-0553 [Abstract] [Full Text] [PDF]  

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells

Anna Morena D'Alise, Giovanni Amabile, Mariangela Iovino, Francesco Paolo Di Giorgio, Marta Bartiromo, Fabio Sessa, Fabrizio Villa, Andrea Musacchio, and Riccardo Cortese
Mol Cancer Ther 2008 7: 1140-1149 doi: 10.1158/1535-7163.MCT-07-2051 [Abstract] [Full Text] [PDF] Supplementary Material  

MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer

Tetsuya Oguri, Hiroaki Ozasa, Takehiro Uemura, Yuji Bessho, Mikinori Miyazaki, Ken Maeno, Hiroyoshi Maeda, Shigeki Sato, and Ryuzo Ueda
Mol Cancer Ther 2008 7: 1150-1155Published Online First April 29, 2008. doi: 10.1158/1535-7163.MCT-07-2088 [Abstract] [Full Text] [PDF]  

Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells

Xia Wang, Wenshu Chen, Weihua Zeng, Lang Bai, Yohannes Tesfaigzi, Steven A. Belinsky, and Yong Lin
Mol Cancer Ther 2008 7: 1156-1163 doi: 10.1158/1535-7163.MCT-07-2183 [Abstract] [Full Text] [PDF]  

p27^Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis

Monica Schiappacassi, Francesca Lovat, Vincenzo Canzonieri, Barbara Belletti, Stefania Berton, Domenica Di Stefano, Andrea Vecchione, Alfonso Colombatti, and Gustavo Baldassarre
Mol Cancer Ther 2008 7: 1164-1175 doi: 10.1158/1535-7163.MCT-07-2154 [Abstract] [Full Text] [PDF] Supplementary Material  

LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells

Daniel B. Lipka, Linda S. Hoffmann, Florian Heidel, Boyka Markova, Marie-Christine Blum, Frank Breitenbuecher, Stefan Kasper, Thomas Kindler, Ross L. Levine, Christoph Huber, and Thomas Fischer
Mol Cancer Ther 2008 7: 1176-1184 doi: 10.1158/1535-7163.MCT-07-2215 [Abstract] [Full Text] [PDF]  

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

Adina Vultur, Ralf Buettner, Claudia Kowolik, Wei Liang, David Smith, Frank Boschelli, and Richard Jove
Mol Cancer Ther 2008 7: 1185-1194 doi: 10.1158/1535-7163.MCT-08-0126 [Abstract] [Full Text] [PDF]  

Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9

Cheng-Wei Lin, Shing-Chun Shen, Wen-Chi Hou, Liang-Yo Yang, and Yen-Chou Chen
Mol Cancer Ther 2008 7: 1195-1206 doi: 10.1158/1535-7163.MCT-07-2199 [Abstract] [Full Text] [PDF]  

Requirement of hypoxia-inducible factor-1 down-regulation in mediating the antitumor activity of the anti–epidermal growth factor receptor monoclonal antibody cetuximab

Xinqun Li, Yang Lu, Ke Liang, Tianhong Pan, John Mendelsohn, and Zhen Fan
Mol Cancer Ther 2008 7: 1207-1217 doi: 10.1158/1535-7163.MCT-07-2187 [Abstract] [Full Text] [PDF]  

Cytotoxicity of the matrix metalloproteinase–activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

Randall W. Alfano, Stephen H. Leppla, Shihui Liu, Thomas H. Bugge, Meenhard Herlyn, Keiran S. Smalley, Jennifer L. Bromberg-White, Nicholas S. Duesbery, and Arthur E. Frankel
Mol Cancer Ther 2008 7: 1218-1226 doi: 10.1158/1535-7163.MCT-08-0024 [Abstract] [Full Text] [PDF] Supplementary Material  

Plasminogen activator inhibitor-1 inhibits prostate tumor growth through endothelial apoptosis

Shang-Chiung Chen, Dale O. Henry, Peter R. Reczek, and Michael K.K. Wong
Mol Cancer Ther 2008 7: 1227-1236 doi: 10.1158/1535-7163.MCT-08-0051 [Abstract] [Full Text] [PDF]  

Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

Gunnar Johansson, Yonatan Y. Mahller, Margaret H. Collins, Mi-Ok Kim, Takahiro Nobukuni, John Perentesis, Timothy P. Cripe, Heidi A. Lane, Sara C. Kozma, George Thomas, and Nancy Ratner
Mol Cancer Ther 2008 7: 1237-1245 doi: 10.1158/1535-7163.MCT-07-2335 [Abstract] [Full Text] [PDF] Supplementary Material  

Ethnic disparities in Americans of European descent versus Americans of African descent related to polymorphic ERCC1, ERCC2, XRCC1, and PARP1

Rui Gao, Douglas K. Price, Tristan Sissung, Eddie Reed, and William D. Figg
Mol Cancer Ther 2008 7: 1246-1250 doi: 10.1158/1535-7163.MCT-07-2206 [Abstract] [Full Text] [PDF]  

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

Karen Liby, Candice C. Black, Darlene B. Royce, Charlotte R. Williams, Renee Risingsong, Mark M. Yore, Xi Liu, Tadashi Honda, Gordon W. Gribble, William W. Lamph, Thomas A. Sporn, Ethan Dmitrovsky, and Michael B. Sporn
Mol Cancer Ther 2008 7: 1251-1257 doi: 10.1158/1535-7163.MCT-08-0023 [Abstract] [Full Text] [PDF]  

Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice

Komal Raina, Subapriya Rajamanickam, Gagan Deep, Meenakshi Singh, Rajesh Agarwal, and Chapla Agarwal
Mol Cancer Ther 2008 7: 1258-1267Published Online First April 29, 2008. doi: 10.1158/1535-7163.MCT-07-2220 [Abstract] [Full Text] [PDF]  

Vitamin D₃ analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57

Lianjun Lu, Jianhua Qiu, Shunli Liu, and Wenjing Luo
Mol Cancer Ther 2008 7: 1268-1274 doi: 10.1158/1535-7163.MCT-07-2222 [Abstract] [Full Text] [PDF]  

Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis

Po-Lin So, Michele A. Fujimoto, and Ervin H. Epstein, Jr.
Mol Cancer Ther 2008 7: 1275-1284 doi: 10.1158/1535-7163.MCT-07-2043 [Abstract] [Full Text] [PDF]  

Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity

Tatjana Mijatovic, Nancy De Nève, Philippe Gailly, Véronique Mathieu, Benjamin Haibe-Kains, Gianluca Bontempi, Javier Lapeira, Christine Decaestecker, Vincenzo Facchini, and Robert Kiss
Mol Cancer Ther 2008 7: 1285-1296 doi: 10.1158/1535-7163.MCT-07-2241 [Abstract] [Full Text] [PDF]  

PBISe, a novel selenium-containing drug for the treatment of malignant melanoma

SubbaRao V. Madhunapantula, Dhimant Desai, Arati Sharma, Sung Jin Huh, Shantu Amin, and Gavin P. Robertson
Mol Cancer Ther 2008 7: 1297-1308 doi: 10.1158/1535-7163.MCT-07-2267 [Abstract] [Full Text] [PDF]  

Relevance of the Fanconi anemia pathway in the response of human cells to trabectedin

José A. Casado, Paula Río, Esther Marco, Verónica García-Hernández, Alberto Domingo, Laura Pérez, Juan Carlos Tercero, Juan José Vaquero, Beatriz Albella, Federico Gago, and Juan A. Bueren
Mol Cancer Ther 2008 7: 1309-1318 doi: 10.1158/1535-7163.MCT-07-2432 [Abstract] [Full Text] [PDF] Supplementary Material  

Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78

Minal Kotecha, Jerome Kluza, Geoff Wells, C. Caroline O'Hare, Claudia Forni, Roberto Mantovani, Philip W. Howard, Peter Morris, David E. Thurston, John A. Hartley, and Daniel Hochhauser
Mol Cancer Ther 2008 7: 1319-1328 doi: 10.1158/1535-7163.MCT-07-0475 [Abstract] [Full Text] [PDF]  

Human papillomavirus type 16 L1E7 chimeric capsomeres have prophylactic and therapeutic efficacy against papillomavirus in mice

Tao Bian, Yue Wang, Zhenhua Lu, Zhenmei Ye, Li Zhao, Jiao Ren, Hui Zhang, Li Ruan, and Houwen Tian
Mol Cancer Ther 2008 7: 1329-1335 doi: 10.1158/1535-7163.MCT-07-2015 [Abstract] [Full Text] [PDF]  

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