Review:

Turning the gene tap off; implications of regulating gene expression for cancer therapeutics

James F. Curtin, Marianela Candolfi, Weidong Xiong, Pedro R. Lowenstein, and Maria G. Castro
Mol Cancer Ther 2008 7: 439-448 doi: 10.1158/1535-7163.MCT-07-2328 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Level of HER-2/neu protein expression in breast cancer may affect the development of endogenous HER-2/neu-specific immunity

Vivian Goodell, James Waisman, Lupe G. Salazar, Corazon dela Rosa, John Link, Andrew L. Coveler, Jennifer S. Childs, Patricia A. Fintak, Doreen M. Higgins, and Mary L. Disis
Mol Cancer Ther 2008 7: 449-454Published Online First March 4, 2008. doi: 10.1158/1535-7163.MCT-07-0386 [Abstract] [Full Text] [PDF]  

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Jeffrey Cummings, Cassandra Hodgkinson, Rajesh Odedra, Patrizia Sini, Simon P. Heaton, Kirsten E. Mundt, Tim H. Ward, Robert W. Wilkinson, Jim Growcott, Andrew Hughes, and Caroline Dive
Mol Cancer Ther 2008 7: 455-463 doi: 10.1158/1535-7163.MCT-07-2136 [Abstract] [Full Text] [PDF]  

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

Michael Sun, Zeev Estrov, Yuan Ji, Kevin R. Coombes, David H. Harris, and Razelle Kurzrock
Mol Cancer Ther 2008 7: 464-473 doi: 10.1158/1535-7163.MCT-07-2272 [Abstract] [Full Text] [PDF]  

Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90

Agustín Hernández, Guillermo López-Lluch, Juan A. Bernal, Plácido Navas, and José A. Pintor-Toro
Mol Cancer Ther 2008 7: 474-482 doi: 10.1158/1535-7163.MCT-07-0457 [Abstract] [Full Text] [PDF] Supplementary Material  

Mitochondrial regulation by c-Myc and hypoxia-inducible factor-1 controls sensitivity to econazole

Yongmao Yu, Maryam Niapour, Yicheng Zhang, and Stuart A. Berger
Mol Cancer Ther 2008 7: 483-491 doi: 10.1158/1535-7163.MCT-07-2050 [Abstract] [Full Text] [PDF]  

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker

Shelby Crawford, Daniel Belajic, Jianmei Wei, Jason P. Riley, Paul J. Dunford, Scott Bembenek, Anne Fourie, James P. Edwards, Lars Karlsson, Anders Brunmark, Ronald L. Wolin, and Jonathan M. Blevitt
Mol Cancer Ther 2008 7: 492-499 doi: 10.1158/1535-7163.MCT-07-0307 [Abstract] [Full Text] [PDF]  

Ellipticine derivative NSC 338258 represents a potential new antineoplastic agent for the treatment of multiple myeloma

Erming Tian, Terry H. Landowski, Owen W. Stephens, Shmuel Yaccoby, Bart Barlogie, and John D. Shaughnessy, Jr.
Mol Cancer Ther 2008 7: 500-509Published Online First March 4, 2008. doi: 10.1158/1535-7163.MCT-07-0524 [Abstract] [Full Text] [PDF]  

Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo

Danijela Maksimovic-Ivanic, Sanja Mijatovic, Ljubica Harhaji, Djordje Miljkovic, Darrin Dabideen, Kai Fan Cheng, Katia Mangano, Graziella Malaponte, Yousef Al-Abed, Massimo Libra, Gianni Garotta, Ferdinando Nicoletti, and Stanislava Stosic-Grujicic
Mol Cancer Ther 2008 7: 510-520 doi: 10.1158/1535-7163.MCT-07-2037 [Abstract] [Full Text] [PDF]  

A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPAR and PPAR activities

Shlomo Handeli and Julian A. Simon
Mol Cancer Ther 2008 7: 521-529 doi: 10.1158/1535-7163.MCT-07-2063 [Abstract] [Full Text] [PDF]  

p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR

Manman Gong, Lin Meng, Beihai Jiang, Jianzhi Zhang, Hua Yang, Jian Wu, and Chengchao Shou
Mol Cancer Ther 2008 7: 530-537 doi: 10.1158/1535-7163.MCT-07-2191 [Abstract] [Full Text] [PDF]  

Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L–like proteases in tumor microenvironment

Roberta E. Burden, Philip Snoddy, Richard J. Buick, James A. Johnston, Brian Walker, and Christopher J. Scott
Mol Cancer Ther 2008 7: 538-547 doi: 10.1158/1535-7163.MCT-07-0528 [Abstract] [Full Text] [PDF]  

Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation

Charlene K. Mason, Suzanne McFarlane, Patrick G. Johnston, Paul Crowe, Pauline J. Erwin, Mathias M. Domostoj, F. Charles Campbell, Soraya Manaviazar, Karl J. Hale, and Mohamed El-Tanani
Mol Cancer Ther 2008 7: 548-558 doi: 10.1158/1535-7163.MCT-07-2251 [Abstract] [Full Text] [PDF]  

Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue

Sung Hee Hwang, Antonina Rait, Kathleen F. Pirollo, Qi Zhou, Venkata Mahidhar Yenugonda, Gary M. Chinigo, Milton L. Brown, and Esther H. Chang
Mol Cancer Ther 2008 7: 559-568 doi: 10.1158/1535-7163.MCT-07-0548 [Abstract] [Full Text] [PDF]  

Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies

Feng An, Daryl C. Drummond, Shannon Wilson, Dmitri B. Kirpotin, Stephen L. Nishimura, V. Courtney Broaddus, and Bin Liu
Mol Cancer Ther 2008 7: 569-578Published Online First March 4, 2008. doi: 10.1158/1535-7163.MCT-07-2132 [Abstract] [Full Text] [PDF] Supplementary Material  

Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery

Albert Lo, Chin-Tarng Lin, and Han-Chung Wu
Mol Cancer Ther 2008 7: 579-589 doi: 10.1158/1535-7163.MCT-07-2359 [Abstract] [Full Text] [PDF]  

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc^Min/+ mice

Denis Alferez, Robert W. Wilkinson, Jim Watkins, Richard Poulsom, Nikki Mandir, Stephen R. Wedge, Ian T. Pyrah, Neil R. Smith, Lynsay Jackson, Anderson J. Ryan, and Robert A. Goodlad
Mol Cancer Ther 2008 7: 590-598 doi: 10.1158/1535-7163.MCT-07-0433 [Abstract] [Full Text] [PDF]  

Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase

Takafumi Okabe, Isamu Okamoto, Sayaka Tsukioka, Junji Uchida, Tsutomu Iwasa, Takeshi Yoshida, Erina Hatashita, Yuki Yamada, Taroh Satoh, Kenji Tamura, Masahiro Fukuoka, and Kazuhiko Nakagawa
Mol Cancer Ther 2008 7: 599-606 doi: 10.1158/1535-7163.MCT-07-0567 [Abstract] [Full Text] [PDF]  

Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells

Hwang-Phill Kim, Sae-Won Han, Sung-Hak Kim, Seock-Ah Im, Do-Youn Oh, Yung-Jue Bang, and Tae-You Kim
Mol Cancer Ther 2008 7: 607-615 doi: 10.1158/1535-7163.MCT-07-2068 [Abstract] [Full Text] [PDF]  

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Hossein Hamed, William Hawkins, Clint Mitchell, Donna Gilfor, Guo Zhang, Xin-Yan Pei, Yun Dai, Michael P. Hagan, John D. Roberts, Adly Yacoub, Steven Grant, and Paul Dent
Mol Cancer Ther 2008 7: 616-629 doi: 10.1158/1535-7163.MCT-07-2376 [Abstract] [Full Text] [PDF]  

Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer

Vessela Vassileva, Christine J. Allen, and Micheline Piquette-Miller
Mol Cancer Ther 2008 7: 630-637 doi: 10.1158/1535-7163.MCT-07-2117 [Abstract] [Full Text] [PDF]  

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

Berta Laquente, Cristina Lacasa, Mireia M. Ginestà, Oriol Casanovas, Agnès Figueras, Maica Galán, Ignacio García Ribas, Josep Ramon Germà, Gabriel Capellà, and Francesc Viñals
Mol Cancer Ther 2008 7: 638-647 doi: 10.1158/1535-7163.MCT-07-2122 [Abstract] [Full Text] [PDF]  

Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

Yan Ding, Elissa A. Boguslawski, Bree D. Berghuis, John J. Young, Zhongfa Zhang, Kim Hardy, Kyle Furge, Eric Kort, Arthur E. Frankel, Rick V. Hay, James H. Resau, and Nicholas S. Duesbery
Mol Cancer Ther 2008 7: 648-658Published Online First March 4, 2008. doi: 10.1158/1535-7163.MCT-07-2229 [Abstract] [Full Text] [PDF] Supplementary Data  

Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation

Daniel E. Frigo and Donald P. McDonnell
Mol Cancer Ther 2008 7: 659-669 doi: 10.1158/1535-7163.MCT-07-0480 [Abstract] [Full Text] [PDF]  

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

Rosaline C-Y. Hui, Richard E. Francis, Stephanie K. Guest, Joana R. Costa, Ana R. Gomes, Stephen S. Myatt, Jan J. Brosens, and Eric W-F. Lam
Mol Cancer Ther 2008 7: 670-678 doi: 10.1158/1535-7163.MCT-07-0397 [Abstract] [Full Text] [PDF]  

Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds

Valentina Benedetti, Paola Perego, Giovanni Luca Beretta, Elisabetta Corna, Stella Tinelli, Sabina Carla Righetti, Roberto Leone, Piero Apostoli, Cinzia Lanzi, and Franco Zunino
Mol Cancer Ther 2008 7: 679-687 doi: 10.1158/1535-7163.MCT-07-0450 [Abstract] [Full Text] [PDF]  

Modulation of drug resistance by artificial transcription factors

Pilar Blancafort, Mario P. Tschan, Sharon Bergquist, Daniel Guthy, Arndt Brachat, Dennis A. Sheeter, Bruce E. Torbett, Dirk Erdmann, and Carlos F. Barbas, III
Mol Cancer Ther 2008 7: 688-697Published Online First March 4, 2008. doi: 10.1158/1535-7163.MCT-07-0381 [Abstract] [Full Text] [PDF] Supplementary Data  

Antitumor effect of dsRNA-induced p21^WAF1/CIP1 gene activation in human bladder cancer cells

Zhong Chen, Robert F. Place, Zhe-Jun Jia, Deepa Pookot, Rajvir Dahiya, and Long-Cheng Li
Mol Cancer Ther 2008 7: 698-703 doi: 10.1158/1535-7163.MCT-07-2312 [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice

Yuji Takei, Yasushi Saga, Hiroaki Mizukami, Takeshi Takayama, Michitaka Ohwada, Keiya Ozawa, and Mitsuaki Suzuki
Mol Cancer Ther 2008 7: 704-711 doi: 10.1158/1535-7163.MCT-06-0724 [Abstract] [Full Text] [PDF]  

Blockade of viral interleukin-6 expression of Kaposi's sarcoma–associated herpesvirus

Yan-Jin Zhang, Rheba S. Bonaparte, Deendayal Patel, David A. Stein, and Patrick L. Iversen
Mol Cancer Ther 2008 7: 712-720 doi: 10.1158/1535-7163.MCT-07-2036 [Abstract] [Full Text] [PDF]  

A chaperone protein-enriched tumor cell lysate vaccine generates protective humoral immunity in a mouse breast cancer model

Gang Li, Samita Andreansky, Gustavo Helguera, Marjan Sepassi, Nona Janikashvili, Jessica Cantrell, Collin L. LaCasse, Nicolas Larmonier, Manuel L. Penichet, and Emmanuel Katsanis
Mol Cancer Ther 2008 7: 721-729 doi: 10.1158/1535-7163.MCT-07-2067 [Abstract] [Full Text] [PDF]  

Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias

Florencia Cano, Richard Pannel, George A. Follows, and Terence H. Rabbitts
Mol Cancer Ther 2008 7: 730-735 doi: 10.1158/1535-7163.MCT-07-2032 [Abstract] [Full Text] [PDF]  

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