Review:

DNAzyme technology and cancer therapy: cleave and let die

Crispin R. Dass, Peter F.M. Choong, and Levon M. Khachigian
Mol Cancer Ther 2008 7: 243-251 doi: 10.1158/1535-7163.MCT-07-0510 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Defective p53 signaling in p53 wild-type tumors attenuates p21^waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G₂ arrest

Aime A. Levesque, Andrew A. Fanous, Alissa Poh, and Alan Eastman
Mol Cancer Ther 2008 7: 252-262 doi: 10.1158/1535-7163.MCT-07-2066 [Abstract] [Full Text] [PDF]  

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

Hailan Liu, Yang Liu, and Jian-Ting Zhang
Mol Cancer Ther 2008 7: 263-270 doi: 10.1158/1535-7163.MCT-07-0445 [Abstract] [Full Text] [PDF]  

The role of TRPV6 in breast carcinogenesis

Katrin A. Bolanz, Matthias A. Hediger, and Christopher P. Landowski
Mol Cancer Ther 2008 7: 271-279Published Online First February 1, 2008. doi: 10.1158/1535-7163.MCT-07-0478 [Abstract] [Full Text] [PDF]  

Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers

Jianbo Wang, Ryan Day, Yiyu Dong, Steven J. Weintraub, and Loren Michel
Mol Cancer Ther 2008 7: 280-285 doi: 10.1158/1535-7163.MCT-07-2003 [Abstract] [Full Text] [PDF]  

Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer

Min Li, Uddalak Bharadwaj, Rongxin Zhang, Sheng Zhang, Hong Mu, William E. Fisher, F. Charles Brunicardi, Changyi Chen, and Qizhi Yao
Mol Cancer Ther 2008 7: 286-296 doi: 10.1158/1535-7163.MCT-07-0483 [Abstract] [Full Text] [PDF] Supplementary Materials  

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Adly Yacoub, Margaret A. Park, Pankaj Gupta, Mohammed Rahmani, Guo Zhang, Hossein Hamed, David Hanna, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Moira Sauane, Nicollaq Vozhilla, Sarah Spiegel, Costas Koumenis, Martin Graf, David T. Curiel, Steven Grant, Paul B. Fisher, and Paul Dent
Mol Cancer Ther 2008 7: 297-313 doi: 10.1158/1535-7163.MCT-07-2166 [Abstract] [Full Text] [PDF]  

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

Adly Yacoub, Pankaj Gupta, Margaret A. Park, Mohammed Rhamani, Hossein Hamed, David Hanna, Guo Zhang, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Costas Koumenis, David T. Curiel, Steven Grant, Paul B. Fisher, and Paul Dent
Mol Cancer Ther 2008 7: 314-329 doi: 10.1158/1535-7163.MCT-07-2150 [Abstract] [Full Text] [PDF]  

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells

Andreas Vogt, Peter R. McDonald, Aletheia Tamewitz, Rachel P. Sikorski, Peter Wipf, John J. Skoko, III, and John S. Lazo
Mol Cancer Ther 2008 7: 330-340Published Online First February 1, 2008. doi: 10.1158/1535-7163.MCT-07-2165 [Abstract] [Full Text] [PDF]  

Induction of growth arrest and apoptosis in human breast cancer cells by 3,3-diindolylmethane is associated with induction and nuclear localization of p27^kip

Zhiwei Wang, Bennett W. Yu, KM Wahidur Rahman, Fakhara Ahmad, and Fazlul H. Sarkar
Mol Cancer Ther 2008 7: 341-349 doi: 10.1158/1535-7163.MCT-07-0476 [Abstract] [Full Text] [PDF]  

CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo

Shih-Wei Wang, Shiow-Lin Pan, Yu-Chun Huang, Jih-Hwa Guh, Po-Cheng Chiang, Der-Yi Huang, Sheng-Chu Kuo, Kuo-Hsiung Lee, and Che-Ming Teng
Mol Cancer Ther 2008 7: 350-360 doi: 10.1158/1535-7163.MCT-07-2000 [Abstract] [Full Text] [PDF]  

Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines

Andrea Cavazzoni, Roberta R. Alfieri, Caterina Carmi, Valentina Zuliani, Maricla Galetti, Claudia Fumarola, Raffaele Frazzi, Mara Bonelli, Fabrizio Bordi, Alessio Lodola, Marco Mor, and Pier Giorgio Petronini
Mol Cancer Ther 2008 7: 361-370 doi: 10.1158/1535-7163.MCT-07-0477 [Abstract] [Full Text] [PDF]  

6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1–mediated MDR in small cell lung cancer

Giuseppe Filomeni, Paola Turella, Maria Luisa Dupuis, Olindo Forini, Maria Rosa Ciriolo, Maurizio Cianfriglia, Silvia Pezzola, Giorgio Federici, and Anna Maria Caccuri
Mol Cancer Ther 2008 7: 371-379 doi: 10.1158/1535-7163.MCT-07-0487 [Abstract] [Full Text] [PDF]  

Calcitrol (1,25-dihydroxyvitamin D₃) inhibits androgen glucuronidation in prostate cancer cells

Jenny Kaeding, Julie Bélanger, Patrick Caron, Mélanie Verreault, Alain Bélanger, and Olivier Barbier
Mol Cancer Ther 2008 7: 380-390 doi: 10.1158/1535-7163.MCT-07-0455 [Abstract] [Full Text] [PDF]  

IB kinase β inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL⁺ cells

Elizabeth A. Duncan, Christine A. Goetz, Sarah J. Stein, Katie J. Mayo, Brian J. Skaggs, Karl Ziegelbauer, Charles L. Sawyers, and Albert S. Baldwin
Mol Cancer Ther 2008 7: 391-397Published Online First February 1, 2008. doi: 10.1158/1535-7163.MCT-07-0305 [Abstract] [Full Text] [PDF]  

Growth inhibition by STI571 in combination with radiation in human chronic myelogenous leukemia K562 cells

Florence Huguet, Nicole Giocanti, Christophe Hennequin, Martine Croisy, Emmanuel Touboul, and Vincent Favaudon
Mol Cancer Ther 2008 7: 398-406 doi: 10.1158/1535-7163.MCT-07-2023 [Abstract] [Full Text] [PDF]  

Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models

Shining Wang, Ping Guo, Xiaomin Wang, Qingyu Zhou, and James M. Gallo
Mol Cancer Ther 2008 7: 407-417 doi: 10.1158/1535-7163.MCT-07-2070 [Abstract] [Full Text] [PDF]  

Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium

Paul Beaudry, Monique Nilsson, Matthew Rioth, Daniela Prox, David Poon, Lanwei Xu, Patrick Zweidler-Mckay, Anderson Ryan, Judah Folkman, Sandra Ryeom, and John Heymach
Mol Cancer Ther 2008 7: 418-424Published Online First February 1, 2008. doi: 10.1158/1535-7163.MCT-07-0568 [Abstract] [Full Text] [PDF]  

Adrenocortical carcinoma survival rates correlated to genomic copy number variants

Elizabeth A. Stephan, Tae-Hoon Chung, Clive S. Grant, Seungchan Kim, Daniel D. Von Hoff, Jeffrey M. Trent, and Michael J. Demeure
Mol Cancer Ther 2008 7: 425-431 doi: 10.1158/1535-7163.MCT-07-0267 [Abstract] [Full Text] [PDF]  

In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against 4β1 integrin

Li Peng, Ruiwu Liu, Mirela Andrei, Wenwu Xiao, and Kit S. Lam
Mol Cancer Ther 2008 7: 432-437Published Online First February 1, 2008. doi: 10.1158/1535-7163.MCT-07-0575 [Abstract] [Full Text] [PDF]  

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