Spotlight on Molecular Profiling:

MicroRNAs modulate the chemosensitivity of tumor cells

Paul E. Blower, Ji-Hyun Chung, Joseph S. Verducci, Shili Lin, Jong-Kook Park, Zunyan Dai, Chang-Gong Liu, Thomas D. Schmittgen, William C. Reinhold, Carlo M. Croce, John N. Weinstein, and Wolfgang Sadee
Mol Cancer Ther 2008 7: 1-9Published Online First January 9, 2008. doi: 10.1158/1535-7163.MCT-07-0573 [Abstract] [Full Text] [PDF] Supplementary Data  

Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers

Ellen V. Stevens, Satoshi Nishizuka, Smitha Antony, Mark Reimers, Sudhir Varma, Lynn Young, Peter J. Munson, John N. Weinstein, Elise C. Kohn, and Yves Pommier
Mol Cancer Ther 2008 7: 10-18Published Online First January 9, 2008. doi: 10.1158/1535-7163.MCT-07-0192 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Association of the CYP1B1*3 allele with survival in patients with prostate cancer receiving docetaxel

Tristan M. Sissung, Romano Danesi, Douglas K. Price, Seth M. Steinberg, Ronald de Wit, Muhammad Zahid, Nilesh Gaikwad, Ercole Cavalieri, William L. Dahut, Dan L. Sackett, William D. Figg, and Alex Sparreboom
Mol Cancer Ther 2008 7: 19-26Published Online First January 9, 2008. doi: 10.1158/1535-7163.MCT-07-0557 [Abstract] [Full Text] [PDF]  

Early detection of ovarian cancer using group biomarkers

Alain B. Tchagang, Ahmed H. Tewfik, Melissa S. DeRycke, Keith M. Skubitz, and Amy P.N. Skubitz
Mol Cancer Ther 2008 7: 27-37Published Online First January 9, 2008. doi: 10.1158/1535-7163.MCT-07-0565 [Abstract] [Full Text] [PDF]  

Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression

Katherine M. Aird, Xiuyun Ding, Aris Baras, Junping Wei, Michael A. Morse, Timothy Clay, Herbert K. Lyerly, and Gayathri R. Devi
Mol Cancer Ther 2008 7: 38-47 doi: 10.1158/1535-7163.MCT-07-0370 [Abstract] [Full Text] [PDF]  

CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells

Linhua Jin, Yoko Tabe, Sergej Konoplev, Yuanyuan Xu, Clinton E. Leysath, Hongbo Lu, Shinya Kimura, Akimichi Ohsaka, Mary-Beth Rios, Leslie Calvert, Hagop Kantarjian, Michael Andreeff, and Marina Konopleva
Mol Cancer Ther 2008 7: 48-58 doi: 10.1158/1535-7163.MCT-07-0042 [Abstract] [Full Text] [PDF]  

Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK)

Lincoln A. Edwards, Janet Woo, Lynsey A. Huxham, Maite Verreault, Wieslawa H. Dragowska, Gigi Chiu, Ashish Rajput, Alastair H. Kyle, Jessica Kalra, Donald Yapp, Hong Yan, Andrew I. Minchinton, David Huntsman, Tim Daynard, Dawn N. Waterhouse, B. Thiessen, Shoukat Dedhar, and Marcel B. Bally
Mol Cancer Ther 2008 7: 59-70 doi: 10.1158/1535-7163.MCT-07-0329 [Abstract] [Full Text] [PDF]  

Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization

An Claes, Pieter Wesseling, Judith Jeuken, Cathy Maass, Arend Heerschap, and William P.J. Leenders
Mol Cancer Ther 2008 7: 71-78Published Online First January 9, 2008. doi: 10.1158/1535-7163.MCT-07-0552 [Abstract] [Full Text] [PDF]  

Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib

Jie Ma and David J. Waxman
Mol Cancer Ther 2008 7: 79-89 doi: 10.1158/1535-7163.MCT-07-0584 [Abstract] [Full Text] [PDF]  

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1

Mei Y. Koh, Taly Spivak-Kroizman, Sara Venturini, Sarah Welsh, Ryan R. Williams, D. Lynn Kirkpatrick, and Garth Powis
Mol Cancer Ther 2008 7: 90-100 doi: 10.1158/1535-7163.MCT-07-0463 [Abstract] [Full Text] [PDF]  

Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects

Moritz Palmowski, Jochen Huppert, Gesa Ladewig, Peter Hauff, Michael Reinhardt, Margareta M. Mueller, Eva C. Woenne, Juergen W. Jenne, Mathias Maurer, Guenter W. Kauffmann, Wolfhard Semmler, and Fabian Kiessling
Mol Cancer Ther 2008 7: 101-109 doi: 10.1158/1535-7163.MCT-07-0409 [Abstract] [Full Text] [PDF]  

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

Brian Clem, Sucheta Telang, Amy Clem, Abdullah Yalcin, Jason Meier, Alan Simmons, Mary Ann Rasku, Sengodagounder Arumugam, William L. Dean, John Eaton, Andrew Lane, John O. Trent, and Jason Chesney
Mol Cancer Ther 2008 7: 110-120 doi: 10.1158/1535-7163.MCT-07-0482 [Abstract] [Full Text] [PDF]  

Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro

Adam Schayowitz, Gauri Sabnis, Vincent C.O. Njar, and Angela M.H. Brodie
Mol Cancer Ther 2008 7: 121-132 doi: 10.1158/1535-7163.MCT-07-0581 [Abstract] [Full Text] [PDF]  

Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G₂ checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine

Xiaojun Liu, Akira Matsuda, and William Plunkett
Mol Cancer Ther 2008 7: 133-142 doi: 10.1158/1535-7163.MCT-07-0416 [Abstract] [Full Text] [PDF]  

2-[(1-Methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation

Kelly Huber, Poulam Patel, Lei Zhang, Helen Evans, Andrew D. Westwell, Peter M. Fischer, Stephen Chan, and Stewart Martin
Mol Cancer Ther 2008 7: 143-151 doi: 10.1158/1535-7163.MCT-07-0486 [Abstract] [Full Text] [PDF]  

Phytochemistry and pharmacogenomics of natural products derived from traditional chinese medicine and chinese materia medica with activity against tumor cells

Thomas Efferth, Stefan Kahl, Kerstin Paulus, Michael Adams, Rolf Rauh, Herbert Boechzelt, Xiaojiang Hao, Bernd Kaina, and Rudolf Bauer
Mol Cancer Ther 2008 7: 152-161 doi: 10.1158/1535-7163.MCT-07-0073 [Abstract] [Full Text] [PDF]  

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

Tao Zhang, Adel Hamza, Xianhua Cao, Bing Wang, Shuwen Yu, Chang-Guo Zhan, and Duxin Sun
Mol Cancer Ther 2008 7: 162-170 doi: 10.1158/1535-7163.MCT-07-0484 [Abstract] [Full Text] [PDF] Supplementary Data  

z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo

Dong Xiao and Shivendra V. Singh
Mol Cancer Ther 2008 7: 171-180 doi: 10.1158/1535-7163.MCT-07-0491 [Abstract] [Full Text] [PDF]  

β-Ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor- in human colon cancer cells

Naveena B. Janakiram, Indranie Cooma, Altaf Mohammed, Vernon E. Steele, and Chinthalapally V. Rao
Mol Cancer Ther 2008 7: 181-190 doi: 10.1158/1535-7163.MCT-07-0529 [Abstract] [Full Text] [PDF]  

Identification of a novel blocker of IB kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-B

Bokyung Sung, Manoj K. Pandey, Yuki Nakajima, Hiroshi Nishida, Tetsuya Konishi, Madan M. Chaturvedi, and Bharat B. Aggarwal
Mol Cancer Ther 2008 7: 191-201 doi: 10.1158/1535-7163.MCT-07-0406 [Abstract] [Full Text] [PDF]  

Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells

Bret Stephens, Haiyong Han, Galen Hostetter, Michael J. Demeure, and Daniel D. Von Hoff
Mol Cancer Ther 2008 7: 202-210Published Online First January 9, 2008. doi: 10.1158/1535-7163.MCT-07-0542 [Abstract] [Full Text] [PDF]  

In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency

Yoshifumi Takei, Toshio Nemoto, Ping Mu, Tatsuya Fujishima, Takuji Ishimoto, Yasuhiko Hayakawa, Yukio Yuzawa, Seiichi Matsuo, Takashi Muramatsu, and Kenji Kadomatsu
Mol Cancer Ther 2008 7: 211-221 doi: 10.1158/1535-7163.MCT-07-0319 [Abstract] [Full Text] [PDF] Supplementary Material  

Adenovirus-expressed human hyperplasia suppressor gene induces apoptosis in cancer cells

Lina Wu, Zhixin Li, Yingmei Zhang, Pei Zhang, Xiaohui Zhu, Jing Huang, Teng Ma, Tian Lu, Quansheng Song, Qian Li, Yanhong Guo, Jian Tang, Dalong Ma, Kuang-Hueih Chen, and Xiaoyan Qiu
Mol Cancer Ther 2008 7: 222-232 doi: 10.1158/1535-7163.MCT-07-0382 [Abstract] [Full Text] [PDF]  

From plasma membrane to cytoskeleton: a novel function for semaphorin 6A

Silvia Prislei, Simona Mozzetti, Flavia Filippetti, Marta De Donato, Giuseppina Raspaglio, Lucia Cicchillitti, Giovanni Scambia, and Cristiano Ferlini
Mol Cancer Ther 2008 7: 233-241Published Online First January 9, 2008. doi: 10.1158/1535-7163.MCT-07-0390 [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.