Spotlight on Clinical Response: Introduction:

Studies in target-based treatment

Razelle Kurzrock
Mol Cancer Ther 2007 6: 2385Published Online First September 10, 2007. doi: 10.1158/1535-7163.MCT-06-9S [Full Text] [PDF]  

Spotlight on Clinical Response:

Cutaneous castleman's disease responds to anti–interleukin-6 treatment

Bilal Ahmed, Jaime A. Tschen, Philip R. Cohen, Mohamed H. Zaki, Peter L. Rady, Stephen K. Tyring, Robert E. Corringham, and Razelle Kurzrock
Mol Cancer Ther 2007 6: 2386-2390Published Online First August 31, 2007. doi: 10.1158/1535-7163.MCT-07-0256 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Characterization of novel inhibitors of histone acetyltransferases

Elena D. Eliseeva, Vassil Valkov, Manfred Jung, and Mira O. Jung
Mol Cancer Ther 2007 6: 2391-2398 doi: 10.1158/1535-7163.MCT-07-0159 [Abstract] [Full Text] [PDF]  

Improved low molecular weight Myc-Max inhibitors

Huabo Wang, Dalia I. Hammoudeh, Ariele Viacava Follis, Brian E. Reese, John S. Lazo, Steven J. Metallo, and Edward V. Prochownik
Mol Cancer Ther 2007 6: 2399-2408 doi: 10.1158/1535-7163.MCT-07-0005 [Abstract] [Full Text] [PDF]  

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

Malin Wickström, John Inge Johnsen, Frida Ponthan, Lova Segerström, Baldur Sveinbjörnsson, Magnus Lindskog, Henrik Lövborg, Kristina Viktorsson, Rolf Lewensohn, Per Kogner, Rolf Larsson, and Joachim Gullbo
Mol Cancer Ther 2007 6: 2409-2417 doi: 10.1158/1535-7163.MCT-07-0156 [Abstract] [Full Text] [PDF]  

Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms

Bolan Yu, Birgit M. Dietz, Tareisha Dunlap, Irida Kastrati, Daniel D. Lantvit, Cassia R. Overk, Ping Yao, Zhihui Qin, Judy L. Bolton, and Gregory R.J. Thatcher
Mol Cancer Ther 2007 6: 2418-2428 doi: 10.1158/1535-7163.MCT-07-0268 [Abstract] [Full Text] [PDF]  

Gambogic acid inhibits the catalytic activity of human topoisomerase II by binding to its ATPase domain

Yuxin Qin, Linghua Meng, Chaoxin Hu, Wenhu Duan, Zhili Zuo, Liping Lin, Xiongwen Zhang, and Jian Ding
Mol Cancer Ther 2007 6: 2429-2440 doi: 10.1158/1535-7163.MCT-07-0147 [Abstract] [Full Text] [PDF]  

Synthesis and biological activity of stable branched neurotensin peptides for tumor targeting

Chiara Falciani, Monica Fabbrini, Alessandro Pini, Luisa Lozzi, Barbara Lelli, Silvia Pileri, Jlenia Brunetti, Stefano Bindi, Silvia Scali, and Luisa Bracci
Mol Cancer Ther 2007 6: 2441-2448Published Online First August 31, 2007. doi: 10.1158/1535-7163.MCT-07-0164 [Abstract] [Full Text] [PDF]  

The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion

Anita B. Hjelmeland, Kathryn P. Lattimore, Brian E. Fee, Qing Shi, Sarah Wickman, Stephen T. Keir, Mark D. Hjelmeland, David Batt, Darell D. Bigner, Henry S. Friedman, and Jeremy N. Rich
Mol Cancer Ther 2007 6: 2449-2457Published Online First August 31, 2007. doi: 10.1158/1535-7163.MCT-07-0155 [Abstract] [Full Text] [PDF]  

The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo

Lesley-Ann Martin, Julia E. Head, Sunil Pancholi, Janine Salter, Emma Quinn, Simone Detre, Stan Kaye, Angela Howes, Mitch Dowsett, and Stephen R.D. Johnston
Mol Cancer Ther 2007 6: 2458-2467 doi: 10.1158/1535-7163.MCT-06-0452 [Abstract] [Full Text] [PDF]  

AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma

Hung Huynh, Pierce K.H. Chow, and Khee-Chee Soo
Mol Cancer Ther 2007 6: 2468-2476 doi: 10.1158/1535-7163.MCT-07-0162 [Abstract] [Full Text] [PDF]  

The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-B inhibition and enhanced by the presence of PTEN

Yulan Sun, Daret K. St. Clair, Fang Fang, Graham W. Warren, Vivek M. Rangnekar, Peter A. Crooks, and William H. St. Clair
Mol Cancer Ther 2007 6: 2477-2486 doi: 10.1158/1535-7163.MCT-07-0186 [Abstract] [Full Text] [PDF]  

Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status

Olivier Reelfs, Yao-Zhong Xu, Andrew Massey, Peter Karran, and Alan Storey
Mol Cancer Ther 2007 6: 2487-2495 doi: 10.1158/1535-7163.MCT-07-0166 [Abstract] [Full Text] [PDF]  

Hypoxia modulation and radiosensitization by the novel dual EGFR and VEGFR inhibitor AEE788 in spontaneous and related allograft tumor models

Christoph Oehler-Jänne, Wolfram Jochum, Oliver Riesterer, Angela Broggini-Tenzer, Giorgio Caravatti, Van Vuong, and Martin Pruschy
Mol Cancer Ther 2007 6: 2496-2504 doi: 10.1158/1535-7163.MCT-07-0253 [Abstract] [Full Text] [PDF]  

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

Amy L. Howes, Gary G. Chiang, Elizabeth S. Lang, Caroline B. Ho, Garth Powis, Kristiina Vuori, and Robert T. Abraham
Mol Cancer Ther 2007 6: 2505-2514Published Online First August 31, 2007. doi: 10.1158/1535-7163.MCT-06-0698 [Abstract] [Full Text] [PDF]  

Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor–dependent human lung cancer cells

Arthur Edwards, Jiannong Li, Peter Atadja, Kapil Bhalla, and Eric B. Haura
Mol Cancer Ther 2007 6: 2515-2524 doi: 10.1158/1535-7163.MCT-06-0761 [Abstract] [Full Text] [PDF]  

Histone deacetylase inhibitors selectively suppress expression of HDAC7

Milos Dokmanovic, Gisela Perez, Weisheng Xu, Lang Ngo, Cathy Clarke, Raphael B. Parmigiani, and Paul A. Marks
Mol Cancer Ther 2007 6: 2525-2534 doi: 10.1158/1535-7163.MCT-07-0251 [Abstract] [Full Text] [PDF]  

Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones

Catherine E. Whibley, Kerry L. McPhail, Robert A. Keyzers, Michelle F. Maritz, Virna D. Leaner, Michael J. Birrer, Michael T. Davies-Coleman, and Denver T. Hendricks
Mol Cancer Ther 2007 6: 2535-2543 doi: 10.1158/1535-7163.MCT-06-0760 [Abstract] [Full Text] [PDF]  

Kaempferol induces apoptosis in glioblastoma cells through oxidative stress

Vivek Sharma, Christy Joseph, Soumya Ghosh, Anindita Agarwal, Manoj Kumar Mishra, and Ellora Sen
Mol Cancer Ther 2007 6: 2544-2553 doi: 10.1158/1535-7163.MCT-06-0788 [Abstract] [Full Text] [PDF]  

Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma

Won Kim, Jung-Hwan Yoon, Jae-Min Jeong, Gi-Jeong Cheon, Tae-Sup Lee, Jong-In Yang, Su-Cheol Park, and Hyo-Suk Lee
Mol Cancer Ther 2007 6: 2554-2562 doi: 10.1158/1535-7163.MCT-07-0115 [Abstract] [Full Text] [PDF]  

Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFN–based cancer therapy in mice

Maarten Van Roy, Philippe Van Lint, Ineke Van Laere, Ben Wielockx, Carole Wilson, Carlos López-Otin, Stephen Shapiro, and Claude Libert
Mol Cancer Ther 2007 6: 2563-2571 doi: 10.1158/1535-7163.MCT-07-0016 [Abstract] [Full Text] [PDF]  

Selenium inhibition of survivin expression by preventing Sp1 binding to its promoter

Jae Yeon Chun, Yan Hu, Elaine Pinder, Jianguo Wu, Fengzhi Li, and Allen C. Gao
Mol Cancer Ther 2007 6: 2572-2580 doi: 10.1158/1535-7163.MCT-07-0172 [Abstract] [Full Text] [PDF]  

Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway

Li-Hua Chen, Jing Fang, Huaixing Li, Wendy Demark-Wahnefried, and Xu Lin
Mol Cancer Ther 2007 6: 2581-2590 doi: 10.1158/1535-7163.MCT-07-0220 [Abstract] [Full Text] [PDF]  

Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts

Faiy H. Psahoulia, Konstantinos G. Drosopoulos, Lenka Doubravska, Ladislav Andera, and Alexander Pintzas
Mol Cancer Ther 2007 6: 2591-2599 doi: 10.1158/1535-7163.MCT-07-0001 [Abstract] [Full Text] [PDF]  

A platelet biomarker for assessing phosphoinositide 3-kinase inhibition during cancer chemotherapy

Rita K. Bowers, Philip Marder, Lisa J. Green, Candice L. Horn, Andrew L. Faber, and James E. Thomas
Mol Cancer Ther 2007 6: 2600-2607Published Online First August 31, 2007. doi: 10.1158/1535-7163.MCT-06-0746 [Abstract] [Full Text] [PDF]  

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