Reviews:

Lessons learned in the development of targeted therapy for malignant gliomas

Antonio M.P. Omuro, Sandrine Faivre, and Eric Raymond
Mol Cancer Ther 2007 6: 1909-1919 doi: 10.1158/1535-7163.MCT-07-0047 [Abstract] [Full Text] [PDF]  

Regulation of mitosis via mitotic kinases: new opportunities for cancer management

Travis L. Schmit and Nihal Ahmad
Mol Cancer Ther 2007 6: 1920-1931 doi: 10.1158/1535-7163.MCT-06-0781 [Abstract] [Full Text] [PDF]  

Research Articles:

Platelet-derived growth factor receptor-: a novel therapeutic target in human hepatocellular cancer

Peggy Stock, Dulabh Monga, Xinping Tan, Amanda Micsenyi, Nick Loizos, and Satdarshan P.S. Monga
Mol Cancer Ther 2007 6: 1932-1941Published Online First June 29, 2007. doi: 10.1158/1535-7163.MCT-06-0720 [Abstract] [Full Text] [PDF]  

Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors as in situ tumor vaccine for colorectal cancer

Dennis Hoffmann, Wibke Bayer, Thomas Grunwald, and Oliver Wildner
Mol Cancer Ther 2007 6: 1942-1950 doi: 10.1158/1535-7163.MCT-06-0790 [Abstract] [Full Text] [PDF]  

Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

Ellen Weisberg, Andrew L. Kung, Renee D. Wright, Daisy Moreno, Laurie Catley, Arghya Ray, Leigh Zawel, Mary Tran, Jan Cools, Gary Gilliland, Constantine Mitsiades, Douglas W. McMillin, Jingrui Jiang, Elizabeth Hall-Meyers, and James D. Griffin
Mol Cancer Ther 2007 6: 1951-1961 doi: 10.1158/1535-7163.MCT-06-0810 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion

Anne S. Tsao, Dandan He, Babita Saigal, Suyu Liu, J. Jack Lee, Srinivasa Bakkannagari, Nelson G. Ordonez, Waun Ki Hong, Ignacio Wistuba, and Faye M. Johnson
Mol Cancer Ther 2007 6: 1962-1972 doi: 10.1158/1535-7163.MCT-07-0052 [Abstract] [Full Text] [PDF]  

Nuclear factor-B activation: a molecular therapeutic target for estrogen receptor–negative and epidermal growth factor receptor family receptor–positive human breast cancer

Sindhu Singh, Qian Shi, Shannon T. Bailey, Marek J. Palczewski, Arthur B. Pardee, J. Dirk Iglehart, and Debajit K. Biswas
Mol Cancer Ther 2007 6: 1973-1982 doi: 10.1158/1535-7163.MCT-07-0063 [Abstract] [Full Text] [PDF] Supplementary Data  

Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-B signaling

Christine L. Curry, Laura L. Reed, Eugenia Broude, Todd E. Golde, Lucio Miele, and Kimberly E. Foreman
Mol Cancer Ther 2007 6: 1983-1992Published Online First June 29, 2007. doi: 10.1158/1535-7163.MCT-07-0093 [Abstract] [Full Text] [PDF]  

Ovarian cancer cell–derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis

Thorsten Hagemann, Stephen C. Robinson, Richard G. Thompson, Kellie Charles, Hagen Kulbe, and Frances R. Balkwill
Mol Cancer Ther 2007 6: 1993-2002 doi: 10.1158/1535-7163.MCT-07-0118 [Abstract] [Full Text] [PDF]  

ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo

Laura Rosanò, Valeriana Di Castro, Francesca Spinella, Maria Rita Nicotra, Pier Giorgio Natali, and Anna Bagnato
Mol Cancer Ther 2007 6: 2003-2011 doi: 10.1158/1535-7163.MCT-07-0151 [Abstract] [Full Text] [PDF]  

Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

Rakesh Kumar, Victoria B. Knick, Sharon K. Rudolph, Jennifer H. Johnson, Renae M. Crosby, Ming-Chih Crouthamel, Teresa M. Hopper, Charles G. Miller, Laura E. Harrington, James A. Onori, Robert J. Mullin, Tona M. Gilmer, Anne T. Truesdale, Andrea H. Epperly, Amogh Boloor, Jeffrey A. Stafford, Deirdre K. Luttrell, and Mui Cheung
Mol Cancer Ther 2007 6: 2012-2021 doi: 10.1158/1535-7163.MCT-07-0193 [Abstract] [Full Text] [PDF] Supplementary Material  

Preventive effects of Polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols

Ronald A. Lubet, Chung S. Yang, Mao-Jung Lee, Yukihiko Hara, Izet M. Kapetanovic, James A. Crowell, Vernon E. Steele, M. Margaret Juliana, and Clinton J. Grubbs
Mol Cancer Ther 2007 6: 2022-2028 doi: 10.1158/1535-7163.MCT-07-0058 [Abstract] [Full Text] [PDF]  

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

Heath A. Elrod, Yi-Dan Lin, Ping Yue, Xuerong Wang, Sagar Lonial, Fadlo R. Khuri, and Shi-Yong Sun
Mol Cancer Ther 2007 6: 2029-2038Published Online First June 29, 2007. doi: 10.1158/1535-7163.MCT-07-0004 [Abstract] [Full Text] [PDF] Supplementary Material  

TNF-–based accentuation in cryoinjury—dose, delivery, and response

Raghav Goel, David Swanlund, James Coad, Guilio F. Paciotti, and John C. Bischof
Mol Cancer Ther 2007 6: 2039-2047 doi: 10.1158/1535-7163.MCT-06-0676 [Abstract] [Full Text] [PDF]  

Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1,25-dihydroxyvitamin D₃ in prostate cancer cells

Yong Xu, Fang Fang, Daret K. St. Clair, Sajni Josson, Pradoldej Sompol, Ivan Spasojevic, and William H. St. Clair
Mol Cancer Ther 2007 6: 2048-2056Published Online First June 29, 2007. doi: 10.1158/1535-7163.MCT-06-0700 [Abstract] [Full Text] [PDF]  

A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells

Shan Lu, Amy Wang, Shan Lu, and Zhongyun Dong
Mol Cancer Ther 2007 6: 2057-2064 doi: 10.1158/1535-7163.MCT-06-0735 [Abstract] [Full Text] [PDF]  

Trastuzumab causes antibody-dependent cellular cytotoxicity–mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance

Márk Barok, Jorma Isola, Zsuzsanna Pályi-Krekk, Péter Nagy, István Juhász, György Vereb, Päivikki Kauraniemi, Anita Kapanen, Minna Tanner, György Vereb, and János Szöllösi
Mol Cancer Ther 2007 6: 2065-2072 doi: 10.1158/1535-7163.MCT-06-0766 [Abstract] [Full Text] [PDF]  

2-Methoxy antimycin reveals a unique mechanism for Bcl-x_L inhibition

Pamela S. Schwartz, Michael K. Manion, Christine B. Emerson, John S. Fry, Craig M. Schulz, Ian R. Sweet, and David M. Hockenbery
Mol Cancer Ther 2007 6: 2073-2080 doi: 10.1158/1535-7163.MCT-06-0767 [Abstract] [Full Text] [PDF] Supplementary Data  

The HLA A*0201–restricted hTERT_540–548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor

Marco A. Purbhoo, Yi Li, Deborah H. Sutton, Joanna E. Brewer, Emma Gostick, Giovanna Bossi, Bruno Laugel, Ruth Moysey, Emma Baston, Nathaniel Liddy, Brian Cameron, Alan D. Bennett, Rebecca Ashfield, Anita Milicic, David A. Price, Brendan J. Classon, Andrew K. Sewell, and Bent K. Jakobsen
Mol Cancer Ther 2007 6: 2081-2091 doi: 10.1158/1535-7163.MCT-07-0092 [Abstract] [Full Text] [PDF]  

Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein

Kazuhiro Katayama, Sho Yoshioka, Satomi Tsukahara, Junko Mitsuhashi, and Yoshikazu Sugimoto
Mol Cancer Ther 2007 6: 2092-2102 doi: 10.1158/1535-7163.MCT-07-0148 [Abstract] [Full Text] [PDF]  

TRAIL therapy in non–small cell lung cancer cells: sensitization to death receptor–mediated apoptosis by proteasome inhibitor bortezomib

Jens Voortman, Tatiana P. Resende, Mohamed A.I. Abou El Hassan, Giuseppe Giaccone, and Frank A.E. Kruyt
Mol Cancer Ther 2007 6: 2103-2112 doi: 10.1158/1535-7163.MCT-07-0167 [Abstract] [Full Text] [PDF]  

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities

Karen Liby, Tadashi Honda, Charlotte R. Williams, Renee Risingsong, Darlene B. Royce, Nanjoo Suh, Albena T. Dinkova-Kostova, Katherine K. Stephenson, Paul Talalay, Chitra Sundararajan, Gordon W. Gribble, and Michael B. Sporn
Mol Cancer Ther 2007 6: 2113-2119 doi: 10.1158/1535-7163.MCT-07-0180 [Abstract] [Full Text] [PDF]  

Novel antagonists of the thioesterase domain of human fatty acid synthase

Robyn D. Richardson and Jeffrey W. Smith
Mol Cancer Ther 2007 6: 2120-2126 doi: 10.1158/1535-7163.MCT-07-0187 [Abstract] [Full Text] [PDF]  

Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21^WAF1/CIP1 expression with rapamycin

Chun-Te Chiang, Tzong-Der Way, and Jen-Kun Lin
Mol Cancer Ther 2007 6: 2127-2138 doi: 10.1158/1535-7163.MCT-07-0107 [Abstract] [Full Text] [PDF]  

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