Editorial/Perspectives:

Uncommon tumors and exceptional therapies: paradox or paradigm?

Fadi Braiteh and Razelle Kurzrock
Mol Cancer Ther 2007 6: 1175-1179 doi: 10.1158/1535-7163.MCT-06-0674 [Abstract] [Full Text] [PDF]  

Drug Development Series: Review:

The randomized discontinuation trial: a phase II design to assess growth-inhibitory agents

Walter M. Stadler
Mol Cancer Ther 2007 6: 1180-1185 doi: 10.1158/1535-7163.MCT-06-0249 [Abstract] [Full Text] [PDF]  

Review:

Tumor-stroma interactions in pancreatic ductal adenocarcinoma

Daruka Mahadevan and Daniel D. Von Hoff
Mol Cancer Ther 2007 6: 1186-1197Published Online First April 3, 2007. doi: 10.1158/1535-7163.MCT-06-0686 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

Swee Y. Sharp, Chrisostomos Prodromou, Kathy Boxall, Marissa V. Powers, Joanna L. Holmes, Gary Box, Thomas P. Matthews, Kwai-Ming J. Cheung, Andrew Kalusa, Karen James, Angela Hayes, Anthea Hardcastle, Brian Dymock, Paul A. Brough, Xavier Barril, Julie E. Cansfield, Lisa Wright, Allan Surgenor, Nicolas Foloppe, Roderick E. Hubbard, Wynne Aherne, Laurence Pearl, Keith Jones, Edward McDonald, Florence Raynaud, Sue Eccles, Martin Drysdale, and Paul Workman
Mol Cancer Ther 2007 6: 1198-1211 doi: 10.1158/1535-7163.MCT-07-0149 [Abstract] [Full Text] [PDF] Supplementary Data  

MAP-ing glioma invasion: Mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival

Tim Demuth, Linsey B. Reavie, Jessica L. Rennert, Mitsutoshi Nakada, Satoko Nakada, Dominique B. Hoelzinger, Christian E. Beaudry, Amanda N. Henrichs, Eric M. Anderson, and Michael E. Berens
Mol Cancer Ther 2007 6: 1212-1222Published Online First April 3, 2007. doi: 10.1158/1535-7163.MCT-06-0711 [Abstract] [Full Text] [PDF]  

Predicting gefitinib responsiveness in lung cancer by fluorescence in situ hybridization/chromogenic in situ hybridization analysis of EGFR and HER2 in biopsy and cytology specimens

Lorenzo Daniele, Luigia Macrì, Marina Schena, Diego Dongiovanni, Lisa Bonello, Enrico Armando, Libero Ciuffreda, Oscar Bertetto, Gianni Bussolati, and Anna Sapino
Mol Cancer Ther 2007 6: 1223-1229Published Online First April 3, 2007. doi: 10.1158/1535-7163.MCT-06-0719 [Abstract] [Full Text] [PDF]  

Use of fluorescent labeled anti–epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenografts

Eben L. Rosenthal, Brian D. Kulbersh, Teresa King, Tandra R. Chaudhuri, and Kurt R. Zinn
Mol Cancer Ther 2007 6: 1230-1238 doi: 10.1158/1535-7163.MCT-06-0741 [Abstract] [Full Text] [PDF]  

H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation

Brett Ewald, Deepa Sampath, and William Plunkett
Mol Cancer Ther 2007 6: 1239-1248Published Online First April 3, 2007. doi: 10.1158/1535-7163.MCT-06-0633 [Abstract] [Full Text] [PDF]  

Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1–dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic

Anna Herman-Antosiewicz, Silvia D. Stan, Eun-Ryeong Hahm, Dong Xiao, and Shivendra V. Singh
Mol Cancer Ther 2007 6: 1249-1261Published Online First April 3, 2007. doi: 10.1158/1535-7163.MCT-06-0477 [Abstract] [Full Text] [PDF]  

Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib

Peter Pyrko, Adel Kardosh, Yen-Ting Liu, Nathaniel Soriano, Wenyong Xiong, Robert H. Chow, Jasim Uddin, Nicos A. Petasis, Austin K. Mircheff, Robert A. Farley, Stan G. Louie, Thomas C. Chen, and Axel H. Schönthal
Mol Cancer Ther 2007 6: 1262-1275 doi: 10.1158/1535-7163.MCT-06-0629 [Abstract] [Full Text] [PDF]  

Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer

Lan Li, Bilal Ahmed, Kapil Mehta, and Razelle Kurzrock
Mol Cancer Ther 2007 6: 1276-1282 doi: 10.1158/1535-7163.MCT-06-0556 [Abstract] [Full Text] [PDF]  

Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice

Mark Katzenellenbogen, Lina Mizrahi, Orit Pappo, Naama Klopstock, Devorah Olam, Hila Barash, Eytan Domany, Eithan Galun, and Daniel Goldenberg
Mol Cancer Ther 2007 6: 1283-1291 doi: 10.1158/1535-7163.MCT-06-0420 [Abstract] [Full Text] [PDF]  

Loss of mitochondrial membrane potential is inhibited by bombesin in etoposide-induced apoptosis in PC-3 prostate carcinoma cells

Mercedes Salido, Juan L. Gonzalez, and Jose Vilches
Mol Cancer Ther 2007 6: 1292-1299 doi: 10.1158/1535-7163.MCT-06-0681 [Abstract] [Full Text] [PDF]  

The RET oncogene is a critical component of transcriptional programs associated with retinoic acid–induced differentiation in neuroblastoma

Orit Oppenheimer, Nai-Kong Cheung, and William L. Gerald
Mol Cancer Ther 2007 6: 1300-1309 doi: 10.1158/1535-7163.MCT-06-0587 [Abstract] [Full Text] [PDF]  

Levels of p27^kip1 determine Aplidin sensitivity

Victoria Moneo, Beatriz G. Serelde, Juan F.M. Leal, Carmen Blanco-Aparicio, Ramon Diaz-Uriarte, Miguel Aracil, Juan C. Tercero, José Jimeno, and Amancio Carnero
Mol Cancer Ther 2007 6: 1310-1316 doi: 10.1158/1535-7163.MCT-06-0729 [Abstract] [Full Text] [PDF]  

Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function

Katherine Schafer-Hales, Jon Iaconelli, James P. Snyder, Andrew Prussia, James H. Nettles, Adel El-Naggar, Fadlo R. Khuri, Paraskevi Giannakakou, and Adam I. Marcus
Mol Cancer Ther 2007 6: 1317-1328 doi: 10.1158/1535-7163.MCT-06-0703 [Abstract] [Full Text] [PDF]  

Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer

Dorit Nahari, Ronit Satchi-Fainaro, Ming Chen, Ian Mitchell, Laurie B. Task, Zijuan Liu, Jason Kihneman, Allison B. Carroll, Lance S. Terada, and Fiemu E. Nwariaku
Mol Cancer Ther 2007 6: 1329-1337 doi: 10.1158/1535-7163.MCT-06-0554 [Abstract] [Full Text] [PDF]  

Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH₂-terminal kinase–mediated p53 phosphorylation and stabilization

Ranxin Shi, Qing Huang, Xinqiang Zhu, Yeong-Bing Ong, Bin Zhao, Jia Lu, Choon-Nam Ong, and Han-Ming Shen
Mol Cancer Ther 2007 6: 1338-1347 doi: 10.1158/1535-7163.MCT-06-0638 [Abstract] [Full Text] [PDF]  

Identification of a novel inhibitor of urokinase-type plasminogen activator

Ming Zhu, Vijay M. Gokhale, Lajos Szabo, Ruben M. Munoz, Hyounggee Baek, Sridevi Bashyam, Laurence H. Hurley, Daniel D. Von Hoff, and Haiyong Han
Mol Cancer Ther 2007 6: 1348-1356 doi: 10.1158/1535-7163.MCT-06-0520 [Abstract] [Full Text] [PDF]  

Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

Ta-Jen Liu, Tiffany LaFortune, Toshiyuki Honda, Osamu Ohmori, Shinji Hatakeyama, Thomas Meyer, Dowdy Jackson, John de Groot, and W.K. Alfred Yung
Mol Cancer Ther 2007 6: 1357-1367 doi: 10.1158/1535-7163.MCT-06-0476 [Abstract] [Full Text] [PDF]  

S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11–induced apoptosis of prostate cancer cells

Subrata Ray, Sunitha Shyam, Gail C. Fraizer, and Alexandru Almasan
Mol Cancer Ther 2007 6: 1368-1378 doi: 10.1158/1535-7163.MCT-05-0414 [Abstract] [Full Text] [PDF]  

Clofibric acid, a peroxisome proliferator–activated receptor ligand, inhibits growth of human ovarian cancer

Yoshihito Yokoyama, Bing Xin, Tatsuhiko Shigeto, Mika Umemoto, Akiko Kasai-Sakamoto, Masayuki Futagami, Shigeki Tsuchida, Fahd Al-Mulla, and Hideki Mizunuma
Mol Cancer Ther 2007 6: 1379-1386 doi: 10.1158/1535-7163.MCT-06-0722 [Abstract] [Full Text] [PDF]  

Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1

Stavroula Baritaki, Sara Huerta-Yepez, Toshiyuki Sakai, Demetrios A. Spandidos, and Benjamin Bonavida
Mol Cancer Ther 2007 6: 1387-1399 doi: 10.1158/1535-7163.MCT-06-0521 [Abstract] [Full Text] [PDF]  

Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells

Sangkil Nam, Ann Williams, Adina Vultur, Alan List, Kapil Bhalla, David Smith, Francis Y. Lee, and Richard Jove
Mol Cancer Ther 2007 6: 1400-1405 doi: 10.1158/1535-7163.MCT-06-0446 [Abstract] [Full Text] [PDF]  

Loss of ataxia telangiectasia mutated– and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival

Deborah Wilsker and Fred Bunz
Mol Cancer Ther 2007 6: 1406-1413 doi: 10.1158/1535-7163.MCT-06-0679 [Abstract] [Full Text] [PDF]  

Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer

Qing Zhang, Neil E. Bhola, Vivian Wai Yan Lui, Doris R. Siwak, Sufi M. Thomas, Christopher T. Gubish, Jill M. Siegfried, Gordon B. Mills, Dong Shin, and Jennifer Rubin Grandis
Mol Cancer Ther 2007 6: 1414-1424 doi: 10.1158/1535-7163.MCT-06-0678 [Abstract] [Full Text] [PDF]  

Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells

Maxy De los Santos, Alberto Zambrano, and Ana Aranda
Mol Cancer Ther 2007 6: 1425-1432 doi: 10.1158/1535-7163.MCT-06-0623 [Abstract] [Full Text] [PDF]  

1,25-dihydroxyvitamin D₃ (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells

Moshe Ben-Shoshan, Sharon Amir, Duyen T. Dang, Long H. Dang, Yosef Weisman, and Nicola J. Mabjeesh
Mol Cancer Ther 2007 6: 1433-1439 doi: 10.1158/1535-7163.MCT-06-0677 [Abstract] [Full Text] [PDF]  

Inhibition of nuclear factor-B augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activation

Yasuhisa Oida, Began Gopalan, Ryo Miyahara, Cynthia D. Branch, Paul Chiao, Sunil Chada, and Rajagopal Ramesh
Mol Cancer Ther 2007 6: 1440-1449 doi: 10.1158/1535-7163.MCT-06-0374 [Abstract] [Full Text] [PDF]  

Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate

Suzanne M. Cutts, Lonnie P. Swift, Vinochani Pillay, Robert A. Forrest, Abraham Nudelman, Ada Rephaeli, and Don R. Phillips
Mol Cancer Ther 2007 6: 1450-1459 doi: 10.1158/1535-7163.MCT-06-0551 [Abstract] [Full Text] [PDF]  

Novel xenograft model expressing human hepatocyte growth factor shows ligand-dependent growth of c-Met–expressing tumors

Todd D. Francone, Ron G. Landmann, Chin-Tung Chen, Mark Y. Sun, Eleanor J. Kuntz, Zhaoshi Zeng, Ronald P. Dematteo, Philip B. Paty, and Martin R. Weiser
Mol Cancer Ther 2007 6: 1460-1466 doi: 10.1158/1535-7163.MCT-06-0466 [Abstract] [Full Text] [PDF]  

Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid–induced cytotoxicity

Wei-Qun Ding and Stuart E. Lind
Mol Cancer Ther 2007 6: 1467-1474 doi: 10.1158/1535-7163.MCT-06-0608 [Abstract] [Full Text] [PDF]  

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