Reviews:

Radiation-induced cell signaling: inside-out and outside-in

Kristoffer Valerie, Adly Yacoub, Michael P. Hagan, David T. Curiel, Paul B. Fisher, Steven Grant, and Paul Dent
Mol Cancer Ther 2007 6: 789-801 doi: 10.1158/1535-7163.MCT-06-0596 [Abstract] [Full Text] [PDF]  

Targeted therapeutics for multiple myeloma: The arrival of a risk-stratified approach

Rafael Fonseca and A. Keith Stewart
Mol Cancer Ther 2007 6: 802-810 doi: 10.1158/1535-7163.MCT-06-0620 [Abstract] [Full Text] [PDF]  

The power and promise of "rewiring" the mitogen-activated protein kinase network in prostate cancer therapeutics

Athanasios G. Papatsoris, Michalis V. Karamouzis, and Athanasios G. Papavassiliou
Mol Cancer Ther 2007 6: 811-819 doi: 10.1158/1535-7163.MCT-06-0610 [Abstract] [Full Text] [PDF]  

Spotlight on Molecular Profiling Article:

Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study

Uma T. Shankavaram, William C. Reinhold, Satoshi Nishizuka, Sylvia Major, Daisaku Morita, Krishna K. Chary, Mark A. Reimers, Uwe Scherf, Ari Kahn, Douglas Dolginow, Jeffrey Cossman, Eric P. Kaldjian, Dominic A. Scudiero, Emanuel Petricoin, Lance Liotta, Jae K. Lee, and John N. Weinstein
Mol Cancer Ther 2007 6: 820-832Published Online First March 5, 2007. doi: 10.1158/1535-7163.MCT-06-0650 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Evaluation of locked nucleic acid–modified small interfering RNA in vitro and in vivo

Olaf R. Mook, Frank Baas, Marit B. de Wissel, and Kees Fluiter
Mol Cancer Ther 2007 6: 833-843 doi: 10.1158/1535-7163.MCT-06-0195 [Abstract] [Full Text] [PDF]  

Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs

Gigi N.C. Chiu, Lincoln A. Edwards, Anita I. Kapanen, Melina M. Malinen, Wieslawa H. Dragowska, Corinna Warburton, Ghania G. Chikh, Karen Y.Y. Fang, Sophia Tan, Jonathan Sy, Catherine Tucker, Dawn N. Waterhouse, Richard Klasa, and Marcel B. Bally
Mol Cancer Ther 2007 6: 844-855Published Online First March 5, 2007. doi: 10.1158/1535-7163.MCT-06-0159 [Abstract] [Full Text] [PDF]  

The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo

Deryk Loo, Nancy Pryer, Peter Young, Tony Liang, Suzanne Coberly, Kathleen L. King, Key Kang, Penny Roberts, Mary Tsao, Xiaolin Xu, Beverly Potts, and Jennie P. Mather
Mol Cancer Ther 2007 6: 856-865 doi: 10.1158/1535-7163.MCT-06-0581 [Abstract] [Full Text] [PDF]  

High-resolution single-photon emission computed tomography and X-ray computed tomography imaging of Tc-99m–labeled anti-DR5 antibody in breast tumor xenografts

Hyunki Kim, Tandra R. Chaudhuri, Donald J. Buchsbaum, Deli Wang, and Kurt R. Zinn
Mol Cancer Ther 2007 6: 866-875 doi: 10.1158/1535-7163.MCT-06-0230 [Abstract] [Full Text] [PDF]  

Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates

Sinan Battah, Sherina Balaratnam, Adriana Casas, Sophie O'Neill, Christine Edwards, Alcira Batlle, Paul Dobbin, and Alexander J. MacRobert
Mol Cancer Ther 2007 6: 876-885 doi: 10.1158/1535-7163.MCT-06-0359 [Abstract] [Full Text] [PDF]  

A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

Tomas Frgala, Ondrej Kalous, Robert T. Proffitt, and C. Patrick Reynolds
Mol Cancer Ther 2007 6: 886-897 doi: 10.1158/1535-7163.MCT-04-0331 [Abstract] [Full Text] [PDF]  

In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway– and microtubule-targeting inhibitors

Natalia Skobeleva, Sanjay Menon, Lutz Weber, Erica A. Golemis, and Vladimir Khazak
Mol Cancer Ther 2007 6: 898-906 doi: 10.1158/1535-7163.MCT-06-0602 [Abstract] [Full Text] [PDF]  

A novel class of pyranocoumarin anti–androgen receptor signaling compounds

Junming Guo, Cheng Jiang, Zhe Wang, Hyo-Jeong Lee, Hongbo Hu, Barbara Malewicz, Hyo-Jung Lee, Jae-Ho Lee, Nam-In Baek, Jin-Hyun Jeong, Dae-Keun Kim, Kyung-Sun Kang, Sung-Hoon Kim, and Junxuan Lu
Mol Cancer Ther 2007 6: 907-917 doi: 10.1158/1535-7163.MCT-06-0231 [Abstract] [Full Text] [PDF]  

In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00

Kalpana S. Joshi, Maggie J. Rathos, Rajendra D. Joshi, Meenakshi Sivakumar, Malcolm Mascarenhas, Shrikant Kamble, Bansi Lal, and Somesh Sharma
Mol Cancer Ther 2007 6: 918-925 doi: 10.1158/1535-7163.MCT-06-0613 [Abstract] [Full Text] [PDF]  

P276-00, a novel cyclin-dependent inhibitor induces G₁-G₂ arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models

Kalpana S. Joshi, Maggie J. Rathos, Pravin Mahajan, Vilas Wagh, Satyendra Shenoy, Dimple Bhatia, Shailaja Chile, Meenakshi Sivakumar, Armin Maier, Heinz-Herbert Fiebig, and Somesh Sharma
Mol Cancer Ther 2007 6: 926-934 doi: 10.1158/1535-7163.MCT-06-0614 [Abstract] [Full Text] [PDF]  

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

Luigi Carlessi, Giacomo Buscemi, Gary Larson, Zhi Hong, Jim Zhen Wu, and Domenico Delia
Mol Cancer Ther 2007 6: 935-944 doi: 10.1158/1535-7163.MCT-06-0567 [Abstract] [Full Text] [PDF]  

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial

Huw D. Thomas, Christopher R. Calabrese, Michael A. Batey, Stacie Canan, Zdenek Hostomsky, Suzanne Kyle, Karen A. Maegley, David R. Newell, Donald Skalitzky, Lan-Zhen Wang, Stephen E. Webber, and Nicola J. Curtin
Mol Cancer Ther 2007 6: 945-956 doi: 10.1158/1535-7163.MCT-06-0552 [Abstract] [Full Text] [PDF] Supplementary Material  

Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

Collins A. Karikari, Indrajit Roy, Eric Tryggestad, Georg Feldmann, Clemencia Pinilla, Kate Welsh, John C. Reed, Elwood P. Armour, John Wong, Joseph Herman, Dinesh Rakheja, and Anirban Maitra
Mol Cancer Ther 2007 6: 957-966Published Online First March 5, 2007. doi: 10.1158/1535-7163.MCT-06-0634 [Abstract] [Full Text] [PDF]  

Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells

Murielle Mimeault, Sonny L. Johansson, Ganesh Vankatraman, Eric Moore, Jean-Pierre Henichart, Patrick Depreux, Ming-Fong Lin, and Surinder K. Batra
Mol Cancer Ther 2007 6: 967-978 doi: 10.1158/1535-7163.MCT-06-0648 [Abstract] [Full Text] [PDF]  

ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment

Karsten H. Weylandt, Maxim Nebrig, Nils Jansen-Rosseck, Joanna S. Amey, David Carmena, Bertram Wiedenmann, Christopher F. Higgins, and Alessandro Sardini
Mol Cancer Ther 2007 6: 979-986 doi: 10.1158/1535-7163.MCT-06-0475 [Abstract] [Full Text] [PDF] Supplementary Data  

Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor

Akihiro Muto, Mayumi Hori, Yosuke Sasaki, Akari Saitoh, Iho Yasuda, Tadahito Maekawa, Tomoe Uchida, Keiko Asakura, Tomonori Nakazato, Toshio Kaneda, Masahiro Kizaki, Yasuo Ikeda, and Tadashi Yoshida
Mol Cancer Ther 2007 6: 987-994 doi: 10.1158/1535-7163.MCT-06-0605 [Abstract] [Full Text] [PDF]  

Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-B signaling in in vivo SKH-1 hairless mice

Som D. Sharma, Syed M. Meeran, and Santosh K. Katiyar
Mol Cancer Ther 2007 6: 995-1005 doi: 10.1158/1535-7163.MCT-06-0661 [Abstract] [Full Text] [PDF]  

Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells

Kashif A. Ahmad, Nathan H. Harris, Andrew D. Johnson, Hans C.N. Lindvall, Guixia Wang, and Khalil Ahmed
Mol Cancer Ther 2007 6: 1006-1012 doi: 10.1158/1535-7163.MCT-06-0491 [Abstract] [Full Text] [PDF]  

Sulforaphane induces cell type–specific apoptosis in human breast cancer cell lines

Allison Pledgie-Tracy, Michele D. Sobolewski, and Nancy E. Davidson
Mol Cancer Ther 2007 6: 1013-1021Published Online First March 5, 2007. doi: 10.1158/1535-7163.MCT-06-0494 [Abstract] [Full Text] [PDF]  

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-B and nuclear factor-B–regulated gene products in IFN-–sensitive and IFN-–resistant human bladder cancer cells

Ashish M. Kamat, Gautam Sethi, and Bharat B. Aggarwal
Mol Cancer Ther 2007 6: 1022-1030 doi: 10.1158/1535-7163.MCT-06-0545 [Abstract] [Full Text] [PDF]  

Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates

Song Li, Yunfei Zhou, Ruiwen Wang, Haitao Zhang, Yan Dong, and Clement Ip
Mol Cancer Ther 2007 6: 1031-1038Published Online First March 5, 2007. doi: 10.1158/1535-7163.MCT-06-0643 [Abstract] [Full Text] [PDF]  

Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer

Basil Hassouneh, Mozaffarul Islam, Thomas Nagel, Quintin Pan, Sofia D. Merajver, and Theodoros N. Teknos
Mol Cancer Ther 2007 6: 1039-1045 doi: 10.1158/1535-7163.MCT-06-0524 [Abstract] [Full Text] [PDF]  

Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non–small cell lung cancer cell line NCI-H460

Jens Voortman, Agnieszka Checinska, Giuseppe Giaccone, Jose A. Rodriguez, and Frank A.E. Kruyt
Mol Cancer Ther 2007 6: 1046-1053 doi: 10.1158/1535-7163.MCT-06-0577 [Abstract] [Full Text] [PDF]  

p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3

Ronald Pak Cheung Wong, Wing Pui Tsang, Pui Yee Chau, Ngai Na Co, Tsun Yee Tsang, and Tim Tak Kwok
Mol Cancer Ther 2007 6: 1054-1061 doi: 10.1158/1535-7163.MCT-06-0336 [Abstract] [Full Text] [PDF]  

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

Wen-Xing Ding, Hong-Min Ni, Xiaoyun Chen, Jian Yu, Lin Zhang, and Xiao-Ming Yin
Mol Cancer Ther 2007 6: 1062-1069 doi: 10.1158/1535-7163.MCT-06-0541 [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting BRAF^V600E in thyroid carcinoma: therapeutic implications

Constantine S. Mitsiades, Joseph Negri, Ciaran McMullan, Douglas W. McMillin, Elias Sozopoulos, Galinos Fanourakis, Gerassimos Voutsinas, Sophia Tseleni-Balafouta, Vassiliki Poulaki, David Batt, and Nicholas Mitsiades
Mol Cancer Ther 2007 6: 1070-1078 doi: 10.1158/1535-7163.MCT-06-0449 [Abstract] [Full Text] [PDF]  

Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer

Antonio Jimeno, Belen Rubio-Viqueira, Maria L. Amador, Victor Grunwald, Anirban Maitra, Christine Iacobuzio-Donahue, and Manuel Hidalgo
Mol Cancer Ther 2007 6: 1079-1088 doi: 10.1158/1535-7163.MCT-06-0448 [Abstract] [Full Text] [PDF]  

Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets

Vasyl' F. Chekhun, Nataliya Yu Lukyanova, Olga Kovalchuk, Volodymyr P. Tryndyak, and Igor P. Pogribny
Mol Cancer Ther 2007 6: 1089-1098 doi: 10.1158/1535-7163.MCT-06-0663 [Abstract] [Full Text] [PDF]  

Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells

Shambhunath Choudhary and Hwa-Chain Robert Wang
Mol Cancer Ther 2007 6: 1099-1111 doi: 10.1158/1535-7163.MCT-06-0586 [Abstract] [Full Text] [PDF]  

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation

Anthea Hardcastle, Peter Tomlin, Clair Norris, Juliet Richards, Matthew Cordwell, Katherine Boxall, Martin Rowlands, Keith Jones, Ian Collins, Edward McDonald, Paul Workman, and Wynne Aherne
Mol Cancer Ther 2007 6: 1112-1122 doi: 10.1158/1535-7163.MCT-06-0496 [Abstract] [Full Text] [PDF]  

Inhibition of heat shock protein 90 impairs epidermal growth factor–mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo

Sven A. Lang, Dagmar Klein, Christian Moser, Andreas Gaumann, Gabriel Glockzin, Marc H. Dahlke, Wolfgang Dietmaier, Ulrich Bolder, Hans J. Schlitt, Edward K. Geissler, and Oliver Stoeltzing
Mol Cancer Ther 2007 6: 1123-1132 doi: 10.1158/1535-7163.MCT-06-0628 [Abstract] [Full Text] [PDF]  

Blockade of the phosphatidylinositol-3-kinase–Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated

Yusuke Fujiwara, Yoshihisa Hosokawa, Kazushi Watanabe, Susumu Tanimura, Kei-ichi Ozaki, and Michiaki Kohno
Mol Cancer Ther 2007 6: 1133-1142 doi: 10.1158/1535-7163.MCT-06-0639 [Abstract] [Full Text] [PDF]  

Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis

Jing Wang, Karen Kuropatwinski, Jennie Hauser, Michael R. Rossi, Yunfei Zhou, Alexis Conway, Julie L.C. Kan, Neil W. Gibson, James K.V. Willson, John K. Cowell, and Michael G. Brattain
Mol Cancer Ther 2007 6: 1143-1150 doi: 10.1158/1535-7163.MCT-06-0555 [Abstract] [Full Text] [PDF]  

Inactivation of glycogen synthase kinase-3ß, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells

Muthusamy Kunnimalaiyaan, Abram M. Vaccaro, Mary A. Ndiaye, and Herbert Chen
Mol Cancer Ther 2007 6: 1151-1158 doi: 10.1158/1535-7163.MCT-06-0665 [Abstract] [Full Text] [PDF]  

Resistance to c-KIT kinase inhibitors conferred by V654A mutation

Kathryn G. Roberts, Adam F. Odell, Ellen M. Byrnes, Rosa M. Baleato, Renate Griffith, Alan Bruce Lyons, and Leonie K. Ashman
Mol Cancer Ther 2007 6: 1159-1166 doi: 10.1158/1535-7163.MCT-06-0641 [Abstract] [Full Text] [PDF]  

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

Jann N. Sarkaria, Lin Yang, Patrick T. Grogan, Gaspar J. Kitange, Brett L. Carlson, Mark A. Schroeder, Evanthia Galanis, Caterina Giannini, Wenting Wu, Eduard B. Dinca, and C. David James
Mol Cancer Ther 2007 6: 1167-1174 doi: 10.1158/1535-7163.MCT-06-0691 [Abstract] [Full Text] [PDF]  

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