Research Articles: Therapeutics, Targets, and Development:

Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen

Eric A. Ariazi, Andrei Leitão, Tudor I. Oprea, Bin Chen, Teresa Louis, Anne Marie Bertucci, Catherine G.N. Sharma, Shaun D. Gill, Helen R. Kim, Heather A. Shupp, Jennifer R. Pyle, Alexis Madrack, Anne L. Donato, Dong Cheng, James R. Paige, and V. Craig Jordan
Mol Cancer Ther 2007 6: 2817-2827Published Online First November 7, 2007. doi: 10.1158/1535-7163.MCT-07-0312 [Abstract] [Full Text] [PDF] Supplementary Data  

Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics

Lee-Yee Choong, Simin Lim, Marie Chiew-Shia Loh, Xiaohui Man, Yunhao Chen, Weiyi Toy, Mengfei Pan, Chien-Shing Chen, Anuradha Poonepalli, M. Prakash Hande, Puay-Hoon Tan, Manuel Salto-Tellez, Chow-Yin Wong, Nilesh Shah, Brian J. Druker, and Yoon-Pin Lim
Mol Cancer Ther 2007 6: 2828-2842Published Online First November 7, 2007. doi: 10.1158/1535-7163.MCT-06-0809 [Abstract] [Full Text] [PDF]  

Roles of human epidermal growth factor receptor 2, c-jun NH₂-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells

Xiao-Feng Le, Aruni S. Arachchige-Don, Weiqun Mao, Mary C. Horne, and Robert C. Bast, Jr.
Mol Cancer Ther 2007 6: 2843-2857 doi: 10.1158/1535-7163.MCT-07-0109 [Abstract] [Full Text] [PDF]  

Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells

Ying Chi Ip, Siu Tim Cheung, Yuk Ting Lee, Jenny C. Ho, and Sheung Tat Fan
Mol Cancer Ther 2007 6: 2858-2867 doi: 10.1158/1535-7163.MCT-07-0453 [Abstract] [Full Text] [PDF]  

Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo

Christian Moser, Sven A. Lang, Silvia Kainz, Andreas Gaumann, Stefan Fichtner-Feigl, Gudrun E. Koehl, Hans J. Schlitt, Edward K. Geissler, and Oliver Stoeltzing
Mol Cancer Ther 2007 6: 2868-2878 doi: 10.1158/1535-7163.MCT-07-0410 [Abstract] [Full Text] [PDF]  

Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment

Jie Ma and David J. Waxman
Mol Cancer Ther 2007 6: 2879-2890Published Online First November 7, 2007. doi: 10.1158/1535-7163.MCT-07-0297 [Abstract] [Full Text] [PDF]  

Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection

Ritu Aneja, Vandana Kalia, Rafi Ahmed, and Harish C. Joshi
Mol Cancer Ther 2007 6: 2891-2899 doi: 10.1158/1535-7163.MCT-07-0359 [Abstract] [Full Text] [PDF]  

Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model

Peter Brader, Christopher Cesare Riedl, Yanghee Woo, Vladimir Ponomarev, Pat Zanzonico, Bixiu Wen, Shangde Cai, Hedvig Hricak, Yuman Fong, Ronald Blasberg, and Inna Serganova
Mol Cancer Ther 2007 6: 2900-2908Published Online First November 7, 2007. doi: 10.1158/1535-7163.MCT-07-0432 [Abstract] [Full Text] [PDF]  

Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells

Robert C. Cho, Peter D. Cole, Kyoung-Jin Sohn, Gregory Gaisano, Ruth Croxford, Barton A. Kamen, and Young-In Kim
Mol Cancer Ther 2007 6: 2909-2920 doi: 10.1158/1535-7163.MCT-07-0449 [Abstract] [Full Text] [PDF]  

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

Sean D. McAllister, Rigel T. Christian, Maxx P. Horowitz, Amaia Garcia, and Pierre-Yves Desprez
Mol Cancer Ther 2007 6: 2921-2927 doi: 10.1158/1535-7163.MCT-07-0371 [Abstract] [Full Text] [PDF]  

A prostate-specific antigen–activated N-(2-hydroxypropyl) methacrylamide copolymer prodrug as dual-targeted therapy for prostate cancer

Sachin S. Chandran, Anjan Nan, D. Marc Rosen, Hamidreza Ghandehari, and Samuel R. Denmeade
Mol Cancer Ther 2007 6: 2928-2937 doi: 10.1158/1535-7163.MCT-07-0392 [Abstract] [Full Text] [PDF]  

Clusterin mediates TRAIL resistance in prostate tumor cells

David A. Sallman, Xianghong Chen, Bin Zhong, Danielle L. Gilvary, Junmin Zhou, Sheng Wei, and Julie Y. Djeu
Mol Cancer Ther 2007 6: 2938-2947 doi: 10.1158/1535-7163.MCT-07-0345 [Abstract] [Full Text] [PDF]  

Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells

Angela Sutton, Veronique Friand, Dulce Papy-Garcia, Maylis Dagouassat, Loïc Martin, Roger Vassy, Oualid Haddad, Odile Sainte-Catherine, Michel Kraemer, Line Saffar, Gerard Yves Perret, Jose Courty, Liliane Gattegno, and Nathalie Charnaux
Mol Cancer Ther 2007 6: 2948-2958 doi: 10.1158/1535-7163.MCT-07-0114 [Abstract] [Full Text] [PDF]  

Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer

Hung Huynh, Ching Ching Melissa Teo, and Khee Chee Soo
Mol Cancer Ther 2007 6: 2959-2966 doi: 10.1158/1535-7163.MCT-07-0237 [Abstract] [Full Text] [PDF]  

Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells

Ann M. Gillenwater, Meiling Zhong, and Reuben Lotan
Mol Cancer Ther 2007 6: 2967-2975 doi: 10.1158/1535-7163.MCT-04-0344 [Abstract] [Full Text] [PDF]  

Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro

Jürgen Sonnemann, Beata Bumbul, and James F. Beck
Mol Cancer Ther 2007 6: 2976-2984 doi: 10.1158/1535-7163.MCT-07-0221 [Abstract] [Full Text] [PDF]  

Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells

Luni Emdad, Irina V. Lebedeva, Zao-Zhong Su, Devanand Sarkar, Paul Dent, David T. Curiel, and Paul B. Fisher
Mol Cancer Ther 2007 6: 2985-2994 doi: 10.1158/1535-7163.MCT-07-0399 [Abstract] [Full Text] [PDF]  

Conjugation of an anti–transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells

Tracy R. Daniels, Patrick P. Ng, Tracie Delgado, Maureen R. Lynch, Gary Schiller, Gustavo Helguera, and Manuel L. Penichet
Mol Cancer Ther 2007 6: 2995-3008 doi: 10.1158/1535-7163.MCT-07-0330 [Abstract] [Full Text] [PDF]  

Antibody targeting of B-cell maturation antigen on malignant plasma cells

Maureen C. Ryan, Michelle Hering, David Peckham, Charlotte F. McDonagh, Lindsay Brown, Kristine M. Kim, Damon L. Meyer, Roger F. Zabinski, Iqbal S. Grewal, and Paul J. Carter
Mol Cancer Ther 2007 6: 3009-3018 doi: 10.1158/1535-7163.MCT-07-0464 [Abstract] [Full Text] [PDF]  

Antitumor activity of an epithelial cell adhesion molecule–targeted nanovesicular drug delivery system

Sajid Hussain, Andreas Plückthun, Theresa M. Allen, and Uwe Zangemeister-Wittke
Mol Cancer Ther 2007 6: 3019-3027 doi: 10.1158/1535-7163.MCT-07-0615 [Abstract] [Full Text] [PDF]  

Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines

Lourdes Toral-Barza, Wei-Guo Zhang, Xinyi Huang, Leonard A. McDonald, Edward J. Salaski, Laurel R. Barbieri, Wei-Dong Ding, Girija Krishnamurthy, Yong Bo Hu, Judy Lucas, Valerie S. Bernan, Ping Cai, Jeremy I. Levin, Tarek S. Mansour, James J. Gibbons, Robert T. Abraham, and Ker Yu
Mol Cancer Ther 2007 6: 3028-3038Published Online First November 7, 2007. doi: 10.1158/1535-7163.MCT-07-0211 [Abstract] [Full Text] [PDF]  

Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT

Jui-I Chao, Wen-Chi Su, and Huei-Fang Liu
Mol Cancer Ther 2007 6: 3039-3048 doi: 10.1158/1535-7163.MCT-07-0281 [Abstract] [Full Text] [PDF]  

Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

Metin Kurtoglu, Ningguo Gao, Jie Shang, Johnathan C. Maher, Mark A. Lehrman, Medhi Wangpaichitr, Niramol Savaraj, Andrew N. Lane, and Theodore J. Lampidis
Mol Cancer Ther 2007 6: 3049-3058 doi: 10.1158/1535-7163.MCT-07-0310 [Abstract] [Full Text] [PDF]  

MFTZ-1, an actinomycetes subspecies–derived antitumor macrolide, functions as a novel topoisomerase II poison

Cheng-Ying Xie, Hong Zhu, Li-Ping Lin, Ze-Hong Miao, Mei-Yu Geng, Yu-Jun Cai, Yi Chen, Hua-Jun Zhao, Hai-Bin Luo, Xiong-Wen Zhang, Li-Ming Fan, Yue-Mao Shen, and Jian Ding
Mol Cancer Ther 2007 6: 3059-3070 doi: 10.1158/1535-7163.MCT-07-0014 [Abstract] [Full Text] [PDF]  

Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells

Elena P. Moiseeva, Gabriela M. Almeida, George D.D. Jones, and Margaret M. Manson
Mol Cancer Ther 2007 6: 3071-3079 doi: 10.1158/1535-7163.MCT-07-0117 [Abstract] [Full Text] [PDF]  

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