Drug Development Series: Review:

Disrupting insulin-like growth factor signaling as a potential cancer therapy

Deepali Sachdev and Douglas Yee
Mol Cancer Ther 2007 6: 1-12 doi: 10.1158/1535-7163.MCT-06-0080 [Abstract] [Full Text] [PDF]  

Reviews:

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

Zuben E. Sauna and Suresh V. Ambudkar
Mol Cancer Ther 2007 6: 13-23 doi: 10.1158/1535-7163.MCT-06-0155 [Abstract] [Full Text] [PDF]  

Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy

Hong Chang and Aaron D. Schimmer
Mol Cancer Ther 2007 6: 24-30 doi: 10.1158/1535-7163.MCT-06-0443 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Effect of population and gender on chemotherapeutic agent–induced cytotoxicity

Rong Stephanie Huang, Emily O. Kistner, Wasim K. Bleibel, Sunita J. Shukla, and M. Eileen Dolan
Mol Cancer Ther 2007 6: 31-36 doi: 10.1158/1535-7163.MCT-06-0591 [Abstract] [Full Text] [PDF]  

Nuclear factor-B p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101

Jianming Duan, Jay Friedman, Liesl Nottingham, Zhong Chen, Gulshan Ara, and Carter Van Waes
Mol Cancer Ther 2007 6: 37-50 doi: 10.1158/1535-7163.MCT-05-0285 [Abstract] [Full Text] [PDF]  

Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation

Deborah L. Marrocco, Wayne D. Tilley, Tina Bianco-Miotto, Andreas Evdokiou, Howard I. Scher, Richard A. Rifkind, Paul A. Marks, Victoria M. Richon, and Lisa M. Butler
Mol Cancer Ther 2007 6: 51-60Published Online First January 11, 2007. doi: 10.1158/1535-7163.MCT-06-0144 [Abstract] [Full Text] [PDF]  

Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib

Jiabin An and Matthew B. Rettig
Mol Cancer Ther 2007 6: 61-69 doi: 10.1158/1535-7163.MCT-06-0255 [Abstract] [Full Text] [PDF]  

Antitumor effect of the histone deacetylase inhibitor LAQ824 in combination with 13-cis-retinoic acid in human malignant melanoma

Yukihiko Kato, Brenda C. Salumbides, Xiao-Fei Wang, David Z. Qian, Simon Williams, Yongfeng Wei, Tolib B. Sanni, Peter Atadja, and Roberto Pili
Mol Cancer Ther 2007 6: 70-81 doi: 10.1158/1535-7163.MCT-06-0125 [Abstract] [Full Text] [PDF]  

Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide–resistant cancer cells

Moon-Taek Park, Young-Hee Kang, In-Chul Park, Chun-Ho Kim, Yun-Sil Lee, Hee Yong Chung, and Su-Jae Lee
Mol Cancer Ther 2007 6: 82-92 doi: 10.1158/1535-7163.MCT-06-0349 [Abstract] [Full Text] [PDF]  

Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling

Peter Mullen, David A. Cameron, Max Hasmann, John F. Smyth, and Simon P. Langdon
Mol Cancer Ther 2007 6: 93-100 doi: 10.1158/1535-7163.MCT-06-0401 [Abstract] [Full Text] [PDF]  

Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts

Satoshi Anai, Steve Goodison, Kathleen Shiverick, Yoshihiko Hirao, Bob D. Brown, and Charles J. Rosser
Mol Cancer Ther 2007 6: 101-111 doi: 10.1158/1535-7163.MCT-06-0367 [Abstract] [Full Text] [PDF]  

Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod

Sweeta R. Choudhari, Muhammad A. Khan, Genesis Harris, Donald Picker, Gary S. Jacob, Timothy Block, and Kunwar Shailubhai
Mol Cancer Ther 2007 6: 112-121 doi: 10.1158/1535-7163.MCT-06-0561 [Abstract] [Full Text] [PDF]  

MRP8/ABCC11 directly confers resistance to 5-fluorouracil

Tetsuya Oguri, Yuji Bessho, Hiroyuki Achiwa, Hiroaki Ozasa, Ken Maeno, Hiroyoshi Maeda, Shigeki Sato, and Ryuzo Ueda
Mol Cancer Ther 2007 6: 122-127 doi: 10.1158/1535-7163.MCT-06-0529 [Abstract] [Full Text] [PDF]  

The role of spermidine/spermine N¹-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells

Wendy L. Allen, Estelle G. McLean, John Boyer, Andrea McCulla, Peter M. Wilson, Vicky Coyle, Daniel B. Longley, Robert A. Casero, Jr., and Patrick G. Johnston
Mol Cancer Ther 2007 6: 128-137 doi: 10.1158/1535-7163.MCT-06-0303 [Abstract] [Full Text] [PDF]  

Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma

Hung Huynh, Khee Chee Soo, Pierce K.H. Chow, and Evelyn Tran
Mol Cancer Ther 2007 6: 138-146 doi: 10.1158/1535-7163.MCT-06-0436 [Abstract] [Full Text] [PDF]  

Cell cycle phenotype-based optimization of G₂-abrogating peptides yields CBP501 with a unique mechanism of action at the G₂ checkpoint

Shi-Ken Sha, Takuji Sato, Hidetaka Kobayashi, Machiyo Ishigaki, Sayaka Yamamoto, Hitoshi Sato, Asako Takada, Sigetosi Nakajyo, Yasuo Mochizuki, Jonathan M. Friedman, Fong-Chi Cheng, Takashi Okura, Ryohei Kimura, Donald W. Kufe, Daniel D. VonHoff, and Takumi Kawabe
Mol Cancer Ther 2007 6: 147-153 doi: 10.1158/1535-7163.MCT-06-0371 [Abstract] [Full Text] [PDF]  

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes

Melinda S. Yates, Masafumi Tauchi, Fumiki Katsuoka, Kathleen C. Flanders, Karen T. Liby, Tadashi Honda, Gordon W. Gribble, Delinda A. Johnson, Jeffrey A. Johnson, Neal C. Burton, Tomás R. Guilarte, Masayuki Yamamoto, Michael B. Sporn, and Thomas W. Kensler
Mol Cancer Ther 2007 6: 154-162 doi: 10.1158/1535-7163.MCT-06-0516 [Abstract] [Full Text] [PDF]  

Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

Sheldon Holder, Marina Zemskova, Chao Zhang, Maryam Tabrizizad, Ryan Bremer, Jonathan W. Neidigh, and Michael B. Lilly
Mol Cancer Ther 2007 6: 163-172Published Online First January 11, 2007. doi: 10.1158/1535-7163.MCT-06-0397 [Abstract] [Full Text] [PDF] Supplementary Data  

HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor

Natalya M. Kogan, Michael Schlesinger, Esther Priel, Ruth Rabinowitz, Eduard Berenshtein, Mordechai Chevion, and Raphael Mechoulam
Mol Cancer Ther 2007 6: 173-183 doi: 10.1158/1535-7163.MCT-06-0039 [Abstract] [Full Text] [PDF]  

Eupalmerin acetate, a novel anticancer agent from Caribbean gorgonian octocorals, induces apoptosis in malignant glioma cells via the c-Jun NH₂-terminal kinase pathway

Arifumi Iwamaru, Eiji Iwado, Seiji Kondo, Robert A. Newman, Burnilda Vera, Abimael D. Rodríguez, and Yasuko Kondo
Mol Cancer Ther 2007 6: 184-192 doi: 10.1158/1535-7163.MCT-06-0422 [Abstract] [Full Text] [PDF]  

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia–mutated nuclear protein kinase activation

Shin-Hun Juang, Chia-Chi Lung, Pi-Chen Hsu, Kuo-Shun Hsu, Yu-Chen Li, Pao-Chiung Hong, Her-Shyong Shiah, Ching-Chuan Kuo, Ching-Wei Huang, Yu-Chin Wang, Leeyuan Huang, Tom S. Chen, Shyh-Fong Chen, Kuo-Chu Fu, Cheng-Li Hsu, Meng-Ju Lin, Ching-jer Chang, Curtis L. Ashendel, Thomas C.K. Chan, Kai-Ming Chou, and Jang-Yang Chang
Mol Cancer Ther 2007 6: 193-202 doi: 10.1158/1535-7163.MCT-06-0482 [Abstract] [Full Text] [PDF]  

Preclinical evaluation of ²¹³Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma

Tamantha K. Stutchbury, Fares Al-ejeh, Gillian E. Stillfried, David R. Croucher, John Andrews, David Irving, Matthew Links, and Marie Ranson
Mol Cancer Ther 2007 6: 203-212 doi: 10.1158/1535-7163.MCT-06-0264 [Abstract] [Full Text] [PDF]  

XR5944: A potent inhibitor of estrogen receptors

Chandanamali Punchihewa, Adrian De Alba, Neil Sidell, and Danzhou Yang
Mol Cancer Ther 2007 6: 213-219Published Online First January 11, 2007. doi: 10.1158/1535-7163.MCT-06-0392 [Abstract] [Full Text] [PDF]  

Chrysin inhibits expression of hypoxia-inducible factor-1 through reducing hypoxia-inducible factor-1 stability and inhibiting its protein synthesis

Beibei Fu, Jing Xue, Zhaodong Li, Xianglin Shi, Bing-Hua Jiang, and Jing Fang
Mol Cancer Ther 2007 6: 220-226 doi: 10.1158/1535-7163.MCT-06-0526 [Abstract] [Full Text] [PDF]  

Adenovirus type 5 E1A gene therapy for ovarian clear cell carcinoma: a potential treatment strategy

Hiroaki Itamochi, Junzo Kigawa, Yasunobu Kanamori, Tetsuro Oishi, Chandra Bartholomeusz, Rita Nahta, Francisco J. Esteva, Nour Sneige, Naoki Terakawa, and Naoto T. Ueno
Mol Cancer Ther 2007 6: 227-235Published Online First January 11, 2007. doi: 10.1158/1535-7163.MCT-05-0499 [Abstract] [Full Text] [PDF]  

Heat-inducible in vivo gene therapy of colon carcinoma by human mdr1 promoter–regulated tumor necrosis factor- expression

Wolfgang Walther, Franziska Arlt, Iduna Fichtner, Jutta Aumann, Ulrike Stein, and Peter M. Schlag
Mol Cancer Ther 2007 6: 236-243 doi: 10.1158/1535-7163.MCT-06-0070 [Abstract] [Full Text] [PDF]  

Pulmonary adenocarcinoma–targeted gene therapy by a cancer- and tissue-specific promoter system

Takuya Fukazawa, Yutaka Maeda, Mary L. Durbin, Toru Nakai, Junji Matsuoka, Hirotoshi Tanaka, Yoshio Naomoto, and Noriaki Tanaka
Mol Cancer Ther 2007 6: 244-252 doi: 10.1158/1535-7163.MCT-06-0408 [Abstract] [Full Text] [PDF]  

Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway

Charles Van Sant, Gang Wang, Mark G. Anderson, Oscar J. Trask, Rick Lesniewski, and Dimitri Semizarov
Mol Cancer Ther 2007 6: 253-261 doi: 10.1158/1535-7163.MCT-06-0574 [Abstract] [Full Text] [PDF]  

The JAMM motif of human deubiquitinase Poh1 is essential for cell viability

Melissa Gallery, Jonathan L. Blank, Yinghui Lin, Juan A. Gutierrez, Jacqueline C. Pulido, David Rappoli, Sunita Badola, Mark Rolfe, and Kyle J. MacBeth
Mol Cancer Ther 2007 6: 262-268 doi: 10.1158/1535-7163.MCT-06-0542 [Abstract] [Full Text] [PDF]  

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells

Aparna V. Sarthy, Susan E. Morgan-Lappe, Dorothy Zakula, Lawrence Vernetti, Mark Schurdak, Jeremy C.L. Packer, Mark G. Anderson, Senji Shirasawa, Takehiko Sasazuki, and Stephen W. Fesik
Mol Cancer Ther 2007 6: 269-276 doi: 10.1158/1535-7163.MCT-06-0560 [Abstract] [Full Text] [PDF]  

Molecular correlates of gefitinib responsiveness in human bladder cancer cells

Marissa Shrader, Maria Simona Pino, Gordon Brown, Peter Black, Liana Adam, Menahse Bar-Eli, Colin P.N. Dinney, and David J. McConkey
Mol Cancer Ther 2007 6: 277-285 doi: 10.1158/1535-7163.MCT-06-0513 [Abstract] [Full Text] [PDF]  

Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications

Roberta Venè, Giuseppe Arena, Alessandro Poggi, Cristina D'Arrigo, Michele Mormino, Douglas M. Noonan, Adriana Albini, and Francesca Tosetti
Mol Cancer Ther 2007 6: 286-298 doi: 10.1158/1535-7163.MCT-06-0346 [Abstract] [Full Text] [PDF]  

Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells

Masayuki Kamada, Alan So, Mototsugu Muramaki, Palma Rocchi, Eliana Beraldi, and Martin Gleave
Mol Cancer Ther 2007 6: 299-308Published Online First January 11, 2007. doi: 10.1158/1535-7163.MCT-06-0417 [Abstract] [Full Text] [PDF]  

Synergism between vitamin D and secreted protein acidic and rich in cysteine–induced apoptosis and growth inhibition results in increased susceptibility of therapy-resistant colorectal cancer cells to chemotherapy

Farnaz Taghizadeh, Michelle J. Tang, and Isabella T. Tai
Mol Cancer Ther 2007 6: 309-317 doi: 10.1158/1535-7163.MCT-06-0517 [Abstract] [Full Text] [PDF]  

Pharmacologic inhibition of CDC25 phosphatases impairs interphase microtubule dynamics and mitotic spindle assembly

Martine Cazales, Rose Boutros, Marie-Christine Brezak, Sophie Chaumeron, Grégoire Prevost, and Bernard Ducommun
Mol Cancer Ther 2007 6: 318-325 doi: 10.1158/1535-7163.MCT-06-0299 [Abstract] [Full Text] [PDF]  

The human IgM antibody SAM-6 induces tumor-specific apoptosis with oxidized low-density lipoprotein

Stephanie Brändlein, Nicole Rauschert, Leo Rasche, Angela Dreykluft, Frank Hensel, Ernst Conzelmann, Hans-Konrad Müller-Hermelink, and H. Peter Vollmers
Mol Cancer Ther 2007 6: 326-333 doi: 10.1158/1535-7163.MCT-06-0399 [Abstract] [Full Text] [PDF]  

Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells

Devyani Chaudhuri, Sandra Orsulic, and Badithe T. Ashok
Mol Cancer Ther 2007 6: 334-345 doi: 10.1158/1535-7163.MCT-06-0404 [Abstract] [Full Text] [PDF]  

Modulation of topoisomerase II expression by a DNA sequence-specific polyamide

Daniel Hochhauser, Minal Kotecha, Caroline O'Hare, Peter J. Morris, Janet M. Hartley, Zarmeen Taherbhai, Dorothy Harris, Claudia Forni, Roberto Mantovani, Moses Lee, and John A. Hartley
Mol Cancer Ther 2007 6: 346-354 doi: 10.1158/1535-7163.MCT-06-0503 [Abstract] [Full Text] [PDF]  

Chemotherapeutic selectivity conferred by selenium: a role for p53-dependent DNA repair

Joshua L. Fischer, Elaine M. Mihelc, Karen E. Pollok, and Martin L. Smith
Mol Cancer Ther 2007 6: 355-361 doi: 10.1158/1535-7163.MCT-06-0472 [Abstract] [Full Text] [PDF]  

Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3ß activity in human breast cancer cells

Vanessa Soto-Cerrato, Francesc Viñals, James R. Lambert, Julie A. Kelly, and Ricardo Pérez-Tomás
Mol Cancer Ther 2007 6: 362-369 doi: 10.1158/1535-7163.MCT-06-0266 [Abstract] [Full Text] [PDF]  

The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80

David Kessel, John J. Reiners, Jr., Stuart T. Hazeldine, Lisa Polin, and Jerome P. Horwitz
Mol Cancer Ther 2007 6: 370-379 doi: 10.1158/1535-7163.MCT-05-0386 [Abstract] [Full Text] [PDF]  

A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas

Farzan Siddiqui, Chuan-Yuan Li, Susan M. LaRue, Jean M. Poulson, Paul R. Avery, Amy F. Pruitt, Xiuwu Zhang, Robert L. Ullrich, Donald E. Thrall, Mark W. Dewhirst, and Marlene L. Hauck
Mol Cancer Ther 2007 6: 380-389 doi: 10.1158/1535-7163.MCT-06-0342 [Abstract] [Full Text] [PDF]  

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