Review:

Therapeutic value of glycosaminoglycans in cancer

George W. Yip, Martin Smollich, and Martin Götte
Mol Cancer Ther 2006 5: 2139-2148 doi: 10.1158/1535-7163.MCT-06-0082 [Abstract] [Full Text] [PDF] Supplementary Data  

Research Articles: Therapeutics:

Repression of cell cycle–related proteins by oxaliplatin but not cisplatin in human colon cancer cells

Carole Voland, Annie Bord, Annick Péleraux, Géraldine Pénarier, Dominique Carrière, Sylvaine Galiègue, Esteban Cvitkovic, Omar Jbilo, and Pierre Casellas
Mol Cancer Ther 2006 5: 2149-2157 doi: 10.1158/1535-7163.MCT-05-0212 [Abstract] [Full Text] [PDF]  

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

Han Ying, Sandra L. Biroc, Wei-wei Li, Bruno Alicke, Jian-Ai Xuan, Rene Pagila, Yasuhiro Ohashi, Toshiya Okada, Yoichi Kamata, and Harald Dinter
Mol Cancer Ther 2006 5: 2158-2164 doi: 10.1158/1535-7163.MCT-05-0440 [Abstract] [Full Text] [PDF]  

Gene therapy with TRAIL against renal cell carcinoma

Hiroki Matsubara, Yoichi Mizutani, Fumiya Hongo, Hiroyuki Nakanishi, Yasunori Kimura, So Ushijima, Akihiro Kawauchi, Takahiro Tamura, Tsuneaki Sakata, and Tsuneharu Miki
Mol Cancer Ther 2006 5: 2165-2171 doi: 10.1158/1535-7163.MCT-05-0522 [Abstract] [Full Text] [PDF]  

Cyclin D3 is down-regulated by rapamycin in HER-2-overexpressing breast cancer cells

Pilar García-Morales, Eva Hernando, Estefanía Carrasco-García, María Piedad Menéndez-Gutierrez, Miguel Saceda, and Isabel Martínez-Lacaci
Mol Cancer Ther 2006 5: 2172-2181 doi: 10.1158/1535-7163.MCT-05-0363 [Abstract] [Full Text] [PDF] Supplementary Data  

Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line

Nathalie Auger, Joëlle Thillet, Krystell Wanherdrick, Ahmed Idbaih, Marie-Emmanuelle Legrier, Bernard Dutrillaux, Marc Sanson, and Marie-France Poupon
Mol Cancer Ther 2006 5: 2182-2192 doi: 10.1158/1535-7163.MCT-05-0428 [Abstract] [Full Text] [PDF]  

Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding

Dylan T. Jones and Adrian L. Harris
Mol Cancer Ther 2006 5: 2193-2202 doi: 10.1158/1535-7163.MCT-05-0443 [Abstract] [Full Text] [PDF]  

Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells

Andelko Hrzenjak, Farid Moinfar, Marie-Luise Kremser, Bettina Strohmeier, Philipp B. Staber, Kurt Zatloukal, and Helmut Denk
Mol Cancer Ther 2006 5: 2203-2210 doi: 10.1158/1535-7163.MCT-05-0480 [Abstract] [Full Text] [PDF]  

Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside

Annelies Beckers, Sophie Organe, Leen Timmermans, Frank Vanderhoydonc, Ludo Deboel, Rita Derua, Etienne Waelkens, Koen Brusselmans, Guido Verhoeven, and Johannes V. Swinnen
Mol Cancer Ther 2006 5: 2211-2217 doi: 10.1158/1535-7163.MCT-06-0001 [Abstract] [Full Text] [PDF]  

Antiangiogenic activity of 4'-thio-ß-D-arabinofuranosylcytosine

Anshu M. Roy, Kamal N. Tiwari, William B. Parker, John A. Secrist, III, Rongbao Li, and Zhican Qu
Mol Cancer Ther 2006 5: 2218-2224 doi: 10.1158/1535-7163.MCT-06-0048 [Abstract] [Full Text] [PDF]  

2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules

Kathy Kamath, Tatiana Okouneva, Gary Larson, Dulal Panda, Leslie Wilson, and Mary Ann Jordan
Mol Cancer Ther 2006 5: 2225-2233 doi: 10.1158/1535-7163.MCT-06-0113 [Abstract] [Full Text] [PDF]  

Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent

Kenneth W. Yip, Emma Ito, Xinliang Mao, P.Y. Billie Au, David W. Hedley, Joseph D. Mocanu, Carlo Bastianutto, Aaron Schimmer, and Fei-Fei Liu
Mol Cancer Ther 2006 5: 2234-2240 doi: 10.1158/1535-7163.MCT-06-0134 [Abstract] [Full Text] [PDF]  

Chronic hypoxia promotes hypoxia-inducible factor-1–dependent resistance to etoposide and vincristine in neuroblastoma cells

Deema Hussein, Edward J. Estlin, Caroline Dive, and Guy W.J. Makin
Mol Cancer Ther 2006 5: 2241-2250 doi: 10.1158/1535-7163.MCT-06-0145 [Abstract] [Full Text] [PDF]  

Nuclear factor-B maintains TRAIL resistance in human pancreatic cancer cells

Sanaz Khanbolooki, Steffan T. Nawrocki, Thiruvengadam Arumugam, Robert Andtbacka, Maria S. Pino, Razelle Kurzrock, Craig D. Logsdon, James L. Abbruzzese, and David J. McConkey
Mol Cancer Ther 2006 5: 2251-2260 doi: 10.1158/1535-7163.MCT-06-0075 [Abstract] [Full Text] [PDF]  

High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis

Zhen Fan Yang, Ronnie T.P. Poon, Yuqing Liu, Chi Keung Lau, David W. Ho, Ka Ho Tam, Chi Tat Lam, and Sheung Tat Fan
Mol Cancer Ther 2006 5: 2261-2270 doi: 10.1158/1535-7163.MCT-06-0149 [Abstract] [Full Text] [PDF]  

A non–RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo

Parisa Khalili, Ani Arakelian, Gaoping Chen, Marian L. Plunkett, Ivy Beck, Graham C. Parry, Fernando Doñate, David E. Shaw, Andrew P. Mazar, and Shafaat A. Rabbani
Mol Cancer Ther 2006 5: 2271-2280 doi: 10.1158/1535-7163.MCT-06-0100 [Abstract] [Full Text] [PDF]  

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity

Janice L. Hyatt, Lyudmila Tsurkan, Monika Wierdl, Carol C. Edwards, Mary K. Danks, and Philip M. Potter
Mol Cancer Ther 2006 5: 2281-2288 doi: 10.1158/1535-7163.MCT-06-0160 [Abstract] [Full Text] [PDF]  

Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice

Chandramu Chetty, Praveen Bhoopathi, Pushpa Joseph, Subramanyam Chittivelu, Jasti S. Rao, and Sajani Lakka
Mol Cancer Ther 2006 5: 2289-2299 doi: 10.1158/1535-7163.MCT-06-0169 [Abstract] [Full Text] [PDF]  

A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells

Alison J. Butt, Caroline G. Roberts, Alan A. Seawright, Peter B. Oelrichs, John K. MacLeod, Tracy Y.E. Liaw, Maria Kavallaris, Tiffany J. Somers-Edgar, Gillian M. Lehrbach, Colin K. Watts, and Robert L. Sutherland
Mol Cancer Ther 2006 5: 2300-2309 doi: 10.1158/1535-7163.MCT-06-0170 [Abstract] [Full Text] [PDF]  

Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells

Umasundari Sivaprasad, Tarek Abbas, and Anindya Dutta
Mol Cancer Ther 2006 5: 2310-2316 doi: 10.1158/1535-7163.MCT-06-0175 [Abstract] [Full Text] [PDF]  

Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors

Ann Beliën, Stefanie De Schepper, Wim Floren, Boud Janssens, Ann Mariën, Peter King, Jacky Van Dun, Luc Andries, Jan Voeten, Luc Bijnens, Michel Janicot, and Janine Arts
Mol Cancer Ther 2006 5: 2317-2323 doi: 10.1158/1535-7163.MCT-06-0112 [Abstract] [Full Text] [PDF]  

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator–activated receptor–dependent and independent pathways

Ping Lei, Maen Abdelrahim, and Stephen Safe
Mol Cancer Ther 2006 5: 2324-2336 doi: 10.1158/1535-7163.MCT-06-0184 [Abstract] [Full Text] [PDF]  

Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis

Roy Blum, Jasmine Jacob-Hirsch, Gideon Rechavi, and Yoel Kloog
Mol Cancer Ther 2006 5: 2337-2347 doi: 10.1158/1535-7163.MCT-06-0193 [Abstract] [Full Text] [PDF]  

Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton

Marcel N.A. Bijman, Geerten P. van Nieuw Amerongen, Nancy Laurens, Victor W.M. van Hinsbergh, and Epie Boven
Mol Cancer Ther 2006 5: 2348-2357 doi: 10.1158/1535-7163.MCT-06-0242 [Abstract] [Full Text] [PDF]  

MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death

Eveline Barbieri, Parth Mehta, Zaowen Chen, Linna Zhang, Andrew Slack, Stacey Berg, and Jason M. Shohet
Mol Cancer Ther 2006 5: 2358-2365 doi: 10.1158/1535-7163.MCT-06-0305 [Abstract] [Full Text] [PDF]  

Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice

Ritu Aneja, Jun Zhou, Binfei Zhou, Ramesh Chandra, and Harish C. Joshi
Mol Cancer Ther 2006 5: 2366-2377 doi: 10.1158/1535-7163.MCT-06-0205 [Abstract] [Full Text] [PDF]  

Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH₂-terminal kinase pathways

Chunrong Yu, Bret B. Friday, Jin-Ping Lai, Lin Yang, Jann Sarkaria, Neil E. Kay, Christopher A. Carter, Lewis R. Roberts, Scott H. Kaufmann, and Alex A. Adjei
Mol Cancer Ther 2006 5: 2378-2387 doi: 10.1158/1535-7163.MCT-06-0235 [Abstract] [Full Text] [PDF]  

Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1

Giuliana Cassinelli, Cinzia Lanzi, Giovanna Petrangolini, Monica Tortoreto, Graziella Pratesi, Giuditta Cuccuru, Diletta Laccabue, Rosanna Supino, Sara Belluco, Enrica Favini, Anna Poletti, and Franco Zunino
Mol Cancer Ther 2006 5: 2388-2397 doi: 10.1158/1535-7163.MCT-06-0245 [Abstract] [Full Text] [PDF]  

Research Articles: Targets:

Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells

Tae-Jin Lee, Eun Jung Kim, Shin Kim, Eun Mi Jung, Jong-Wook Park, Seung Hun Jeong, Sang Eun Park, Young Hyun Yoo, and Taeg Kyu Kwon
Mol Cancer Ther 2006 5: 2398-2407 doi: 10.1158/1535-7163.MCT-06-0167 [Abstract] [Full Text] [PDF]  

Enhanced transduction of malignant glioma with a double targeted Ad5/3-RGD fiber-modified adenovirus

Matthew A. Tyler, Ilya V. Ulasov, Anton Borovjagin, Adam M. Sonabend, Andrey Khramtsov, Yu Han, Paul Dent, Paul B. Fisher, David T. Curiel, and Maciej S. Lesniak
Mol Cancer Ther 2006 5: 2408-2416 doi: 10.1158/1535-7163.MCT-06-0187 [Abstract] [Full Text] [PDF]  

Targeting changes in cancer: assessing pathway stability by comparing pathway gene expression coherence levels in tumor and normal tissues

Ruili Huang, Anders Wallqvist, and David G. Covell
Mol Cancer Ther 2006 5: 2417-2427 doi: 10.1158/1535-7163.MCT-06-0239 [Abstract] [Full Text] [PDF]  

Research Article: Development:

Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer

Kang Hyun Choi, Min Woo Park, Seung Yeon Lee, Mi-Ya Jeon, Mee Young Kim, Hee Kyu Lee, Jaehoon Yu, Hong-Jin Kim, Kyungsook Han, Heviran Lee, Keerang Park, Woong June Park, and Sunjoo Jeong
Mol Cancer Ther 2006 5: 2428-2434 doi: 10.1158/1535-7163.MCT-05-0204 [Abstract] [Full Text] [PDF]  

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