Editorials:

Little patients, losing patience: pediatric cancer drug development

Jessica Boklan
Mol Cancer Ther 2006 5: 1905-1908 doi: 10.1158/1535-7163.MCT-06-0179 [Full Text] [PDF]  

Review:

Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery

Rajni Sinha, Gloria J. Kim, Shuming Nie, and Dong M. Shin
Mol Cancer Ther 2006 5: 1909-1917 doi: 10.1158/1535-7163.MCT-06-0141 [Abstract] [Full Text] [PDF]  

Research Articles: Targets:

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

Changjiang Xu, Xiaoling Yuan, Zui Pan, Guoxiang Shen, Jung-Hwan Kim, Siwang Yu, Tin Oo Khor, Wenge Li, Jianjie Ma, and Ah-Ng Tony Kong
Mol Cancer Ther 2006 5: 1918-1926 doi: 10.1158/1535-7163.MCT-05-0497 [Abstract] [Full Text] [PDF]  

A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of antiproliferative and toxic genes

Michael J. Ausserlechner, Petra Obexer, Andrea Deutschmann, Kathrin Geiger, and Reinhard Kofler
Mol Cancer Ther 2006 5: 1927-1934 doi: 10.1158/1535-7163.MCT-05-0500 [Abstract] [Full Text] [PDF]  

Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase–activated protein kinase 2 in mediating DNA damage–induced cell cycle arrest: implications for cancer therapy

Zhan Xiao, John Xue, Thomas J. Sowin, and Haiying Zhang
Mol Cancer Ther 2006 5: 1935-1943 doi: 10.1158/1535-7163.MCT-06-0077 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics:

A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity

Benedict Law, Luisa Quinti, Yongdoo Choi, Ralph Weissleder, and Ching-Hsuan Tung
Mol Cancer Ther 2006 5: 1944-1949 doi: 10.1158/1535-7163.MCT-05-0509 [Abstract] [Full Text] [PDF]  

Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5 T

Manickam Muruganandham, Mihaela Lupu, Jonathan P. Dyke, Cornelia Matei, Michael Linn, Kathryn Packman, Kenneth Kolinsky, Brian Higgins, and Jason A. Koutcher
Mol Cancer Ther 2006 5: 1950-1957 doi: 10.1158/1535-7163.MCT-06-0010 [Abstract] [Full Text] [PDF]  

Therapeutic advantage of combining calcium channel blockers and TRAIL in prostate cancer

Ismail Kaddour-Djebbar, Vijayabaskar Lakshmikanthan, Robert B. Shirley, Yulin Ma, Ronald W. Lewis, and M. Vijay Kumar
Mol Cancer Ther 2006 5: 1958-1966 doi: 10.1158/1535-7163.MCT-06-0011 [Abstract] [Full Text] [PDF]  

Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of -H2AX foci

Anupama Munshi, Toshimitsu Tanaka, Marvette L. Hobbs, Susan L. Tucker, Victoria M. Richon, and Raymond E. Meyn
Mol Cancer Ther 2006 5: 1967-1974 doi: 10.1158/1535-7163.MCT-06-0022 [Abstract] [Full Text] [PDF]  

Antitumor immune response induced by i.t. injection of vector-activated dendritic cells and chemotherapy suppresses metastatic breast cancer

Hakan Akbulut, Yucheng Tang, K. Gonca Akbulut, Jonathan Maynard, Lixin Zhang, and Albert Deisseroth
Mol Cancer Ther 2006 5: 1975-1985 doi: 10.1158/1535-7163.MCT-06-0049 [Abstract] [Full Text] [PDF]  

Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia

Thomas Efferth, Jean-Pierre Gillet, Axel Sauerbrey, Felix Zintl, Vincent Bertholet, Françoise de Longueville, Jose Remacle, and Daniel Steinbach
Mol Cancer Ther 2006 5: 1986-1994 doi: 10.1158/1535-7163.MCT-06-0086 [Abstract] [Full Text] [PDF]  

Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin

Wanida Chearwae, Suneet Shukla, Pornngarm Limtrakul, and Suresh V. Ambudkar
Mol Cancer Ther 2006 5: 1995-2006 doi: 10.1158/1535-7163.MCT-06-0087 [Abstract] [Full Text] [PDF]  

Carboplatin nanocapsules: a highly cytotoxic, phospholipid-based formulation of carboplatin

Irene H.L. Hamelers, Esther van Loenen, Rutger W.H.M. Staffhorst, Ben de Kruijff, and Anton I.P.M. de Kroon
Mol Cancer Ther 2006 5: 2007-2012 doi: 10.1158/1535-7163.MCT-06-0089 [Abstract] [Full Text] [PDF]  

Enhanced killing of pancreatic cancer cells by expression of fusogenic membrane glycoproteins in combination with chemotherapy

Dennis Hoffmann and Oliver Wildner
Mol Cancer Ther 2006 5: 2013-2022 doi: 10.1158/1535-7163.MCT-06-0128 [Abstract] [Full Text] [PDF]  

Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index

Patricia A. Wood, Jovelyn Du-Quiton, Shaojin You, and William J.M. Hrushesky
Mol Cancer Ther 2006 5: 2023-2033 doi: 10.1158/1535-7163.MCT-06-0177 [Abstract] [Full Text] [PDF]  

Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells

Heng-Yuan Tang, Ai Shih, H. James Cao, Faith B. Davis, Paul J. Davis, and Hung-Yun Lin
Mol Cancer Ther 2006 5: 2034-2042 doi: 10.1158/1535-7163.MCT-06-0216 [Abstract] [Full Text] [PDF]  

Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells

Steven E. Canfield, Keyi Zhu, Simon A. Williams, and David J. McConkey
Mol Cancer Ther 2006 5: 2043-2050 doi: 10.1158/1535-7163.MCT-05-0437 [Abstract] [Full Text] [PDF]  

Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity

Elizabeth Buck, Alexandra Eyzaguirre, John D. Haley, Neil W. Gibson, Pablo Cagnoni, and Kenneth K. Iwata
Mol Cancer Ther 2006 5: 2051-2059 doi: 10.1158/1535-7163.MCT-06-0007 [Abstract] [Full Text] [PDF]  

Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/ß-catenin signaling

Hemant K. Roy, Dhananjay P. Kunte, Jennifer L. Koetsier, John Hart, Young L. Kim, Yang Liu, Marc Bissonnette, Michael Goldberg, Vadim Backman, and Ramesh K. Wali
Mol Cancer Ther 2006 5: 2060-2069 doi: 10.1158/1535-7163.MCT-06-0054 [Abstract] [Full Text] [PDF]  

Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A–mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts

Quang-Dé Nguyen, Sylvie Rodrigues, Christelle M. Rodrigue, Christine Rivat, Clara Grijelmo, Erik Bruyneel, Shahin Emami, Samir Attoub, and Christian Gespach
Mol Cancer Ther 2006 5: 2070-2077 doi: 10.1158/1535-7163.MCT-06-0044 [Abstract] [Full Text] [PDF]  

Inhibition of androgen receptor signaling by selenite and methylseleninic acid in prostate cancer cells: two distinct mechanisms of action

Bryan Husbeck, Rumi S. Bhattacharyya, David Feldman, and Susan J. Knox
Mol Cancer Ther 2006 5: 2078-2085 doi: 10.1158/1535-7163.MCT-06-0056 [Abstract] [Full Text] [PDF]  

Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies

Xiaozhong Qian, William J. LaRochelle, Gulshan Ara, Frank Wu, Kamille Dumong Petersen, Annemette Thougaard, Maxwell Sehested, Henri S. Lichenstein, and Michael Jeffers
Mol Cancer Ther 2006 5: 2086-2095 doi: 10.1158/1535-7163.MCT-06-0111 [Abstract] [Full Text] [PDF] Supplementary Material  

Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer

Qing-an Yuan, Heidi H. Simmons, Matthew K. Robinson, Maria Russeva, Wayne A. Marasco, and Gregory P. Adams
Mol Cancer Ther 2006 5: 2096-2105 doi: 10.1158/1535-7163.MCT-06-0115 [Abstract] [Full Text] [PDF]  

Immunomodulatory oligonucleotides as novel therapy for breast cancer: pharmacokinetics, in vitro and in vivo anticancer activity, and potentiation of antibody therapy

Hui Wang, Elizabeth R. Rayburn, Wei Wang, Ekambar R. Kandimalla, Sudhir Agrawal, and Ruiwen Zhang
Mol Cancer Ther 2006 5: 2106-2114 doi: 10.1158/1535-7163.MCT-06-0158 [Abstract] [Full Text] [PDF]  

The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays

Laura Smith, Mark B. Watson, Sara L. O'Kane, Philip J. Drew, Michael J. Lind, and Lynn Cawkwell
Mol Cancer Ther 2006 5: 2115-2120 doi: 10.1158/1535-7163.MCT-06-0190 [Abstract] [Full Text] [PDF]  

Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice

Mallikarjuna Gu, Rana P. Singh, Sivanandhan Dhanalakshmi, Sarumathi Mohan, and Rajesh Agarwal
Mol Cancer Ther 2006 5: 2121-2129 doi: 10.1158/1535-7163.MCT-06-0052 [Abstract] [Full Text] [PDF]  

Research Article: Development:

Sequential oral 9-nitrocamptothecin and etoposide: a pharmacodynamic- and pharmacokinetic-based phase I trial

George R. Simon, Richard M. Lush, Jana Gump, Leticia Tetteh, Charles Williams, Alan Cantor, Scott Antonia, Christopher Garrett, Caio Rocha-Lima, Mayer Fishman, Daniel M. Sullivan, and Pamela N. Munster
Mol Cancer Ther 2006 5: 2130-2137 doi: 10.1158/1535-7163.MCT-06-0034 [Abstract] [Full Text] [PDF]  

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