Editorials:

Is p21 an oncogene?

Andrei L. Gartel
Mol Cancer Ther 2006 5: 1385-1386 doi: 10.1158/1535-7163.MCT-06-0163 [Full Text] [PDF]  

Reviews:

Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer

Elisa Giovannetti, Valentina Mey, Sara Nannizzi, Giuseppe Pasqualetti, Mario Del Tacca, and Romano Danesi
Mol Cancer Ther 2006 5: 1387-1395 doi: 10.1158/1535-7163.MCT-06-0004 [Abstract] [Full Text] [PDF]  

BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions

Ronit I. Yarden and Moshe Z. Papa
Mol Cancer Ther 2006 5: 1396-1404 doi: 10.1158/1535-7163.MCT-05-0471 [Abstract] [Full Text] [PDF]  

Research Articles: Targets:

Roles of nonhomologous end-joining pathways in surviving topoisomerase II–mediated DNA damage

Mobeen Malik, Karin C. Nitiss, Vanessa Enriquez-Rios, and John L. Nitiss
Mol Cancer Ther 2006 5: 1405-1414 doi: 10.1158/1535-7163.MCT-05-0263 [Abstract] [Full Text] [PDF]  

Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1 activity and vascular endothelial growth factor expression in small cell lung cancer cells

Julie Litz and Geoffrey W. Krystal
Mol Cancer Ther 2006 5: 1415-1422 doi: 10.1158/1535-7163.MCT-05-0503 [Abstract] [Full Text] [PDF]  

Therapeutic potential of antisense oligodeoxynucleotides to down-regulate thymidylate synthase in mesothelioma

Janet Flynn, Randal W. Berg, Tracy Wong, Marijke van Aken, Mark D. Vincent, Masakazu Fukushima, and James Koropatnick
Mol Cancer Ther 2006 5: 1423-1433 doi: 10.1158/1535-7163.MCT-06-0073 [Abstract] [Full Text] [PDF]  

Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-B (NF-B) activation and NF-B–regulated gene expression

Haruyo Ichikawa, Yasunari Takada, Shishir Shishodia, Bolleddula Jayaprakasam, Muraleedharan G. Nair, and Bharat B. Aggarwal
Mol Cancer Ther 2006 5: 1434-1445 doi: 10.1158/1535-7163.MCT-06-0096 [Abstract] [Full Text] [PDF]  

Genotoxic-activated G₂-M checkpoint exit is dependent on CDC25B phosphatase expression

Béatrix Bugler, Muriel Quaranta, Bernadette Aressy, Marie-Christine Brezak, Grégoire Prevost, and Bernard Ducommun
Mol Cancer Ther 2006 5: 1446-1451 doi: 10.1158/1535-7163.MCT-06-0099 [Abstract] [Full Text] [PDF]  

The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells

Yan Ji, Hong Jin Lee, Catherine Goodman, Milan Uskokovic, Karen Liby, Michael Sporn, and Nanjoo Suh
Mol Cancer Ther 2006 5: 1452-1458 doi: 10.1158/1535-7163.MCT-06-0136 [Abstract] [Full Text] [PDF]  

ß-Escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21^waf1/cip1 in colon cancer cells

Jagan M.R. Patlolla, Jayadev Raju, Malisetty V. Swamy, and Chinthalapally V. Rao
Mol Cancer Ther 2006 5: 1459-1466 doi: 10.1158/1535-7163.MCT-05-0495 [Abstract] [Full Text] [PDF]  

Functional analysis and molecular modeling show a preserved wild-type activity of p53^C238Y

Marco Ferrone, Federica Perrone, Elena Tamborini, Maria Silvia Paneni, Maurizio Fermeglia, Simona Suardi, Elisa Pastore, Domenico Delia, Marco A. Pierotti, Sabrina Pricl, and Silvana Pilotti
Mol Cancer Ther 2006 5: 1467-1473 doi: 10.1158/1535-7163.MCT-06-0012 [Abstract] [Full Text] [PDF]  

Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97

Leia M. Smith, Albina Nesterova, Stephen C. Alley, Michael Y. Torgov, and Paul J. Carter
Mol Cancer Ther 2006 5: 1474-1482 doi: 10.1158/1535-7163.MCT-06-0026 [Abstract] [Full Text] [PDF]  

Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma

Francesca Spinella, Laura Rosanò, Valeriana Di Castro, Samantha Decandia, Adriana Albini, Maria Rita Nicotra, Pier Giorgio Natali, and Anna Bagnato
Mol Cancer Ther 2006 5: 1483-1492 doi: 10.1158/1535-7163.MCT-06-0053 [Abstract] [Full Text] [PDF]  

Implications of tissue transglutaminase expression in malignant melanoma

Jansina Y. Fok, Suhendan Ekmekcioglu, and Kapil Mehta
Mol Cancer Ther 2006 5: 1493-1503 doi: 10.1158/1535-7163.MCT-06-0083 [Abstract] [Full Text] [PDF]  

Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells

Lorena de la Peña, William E. Burgan, Donna J. Carter, Melinda G. Hollingshead, Merriline Satyamitra, Kevin Camphausen, and Philip J. Tofilon
Mol Cancer Ther 2006 5: 1504-1510 doi: 10.1158/1535-7163.MCT-06-0091 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics:

PM-20, a novel inhibitor of Cdc25A, induces extracellular signal–regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo

Siddhartha Kar, Meifang Wang, Wei Yao, Christopher J. Michejda, and Brian I. Carr
Mol Cancer Ther 2006 5: 1511-1519 doi: 10.1158/1535-7163.MCT-05-0485 [Abstract] [Full Text] [PDF]  

Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells

Daniel Dindo, Felix Dahm, Zdzislaw Szulc, Alicja Bielawska, Lina M. Obeid, Yusuf A. Hannun, Rolf Graf, and Pierre-Alain Clavien
Mol Cancer Ther 2006 5: 1520-1529 doi: 10.1158/1535-7163.MCT-05-0513 [Abstract] [Full Text] [PDF]  

Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

Chinthalapally V. Rao, Bandaru S. Reddy, Vernon E. Steele, C-X Wang, Xiaoping Liu, Nengtai Ouyang, Jagan M.R. Patlolla, Barbara Simi, Levy Kopelovich, and Basil Rigas
Mol Cancer Ther 2006 5: 1530-1538 doi: 10.1158/1535-7163.MCT-06-0061 [Abstract] [Full Text] [PDF]  

Fulvestrant (ICI 182,780) down-regulates androgen receptor expression and diminishes androgenic responses in LNCaP human prostate cancer cells

Rumi S. Bhattacharyya, Aruna V. Krishnan, Srilatha Swami, and David Feldman
Mol Cancer Ther 2006 5: 1539-1549 doi: 10.1158/1535-7163.MCT-06-0065 [Abstract] [Full Text] [PDF]  

A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments

Gregory Z. Ferl, Vania Kenanova, Anna M. Wu, and Joseph J. DiStefano, III
Mol Cancer Ther 2006 5: 1550-1558 doi: 10.1158/1535-7163.MCT-06-0072 [Abstract] [Full Text] [PDF] Supplementary Material  

Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

Maria Nyåkern, Alessandra Cappellini, Irina Mantovani, and Alberto M. Martelli
Mol Cancer Ther 2006 5: 1559-1570 doi: 10.1158/1535-7163.MCT-06-0076 [Abstract] [Full Text] [PDF]  

Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics

Kristen A. Kellar, Matthew V. Lorenzi, Ching Ping Ho, Dan You, Mei-Li Wen, Rolf P. Ryseck, Simone Oppenheimer, Brian E. Fink, Gregory D. Vite, Bruce R. Rowley, Chiang Yu, David K. Bol, Francis Y. Lee, and Tai W. Wong
Mol Cancer Ther 2006 5: 1571-1576 doi: 10.1158/1535-7163.MCT-06-0078 [Abstract] [Full Text] [PDF]  

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy

K. Jin Yoon, Jianjun Qi, Joanna S. Remack, Kristopher G. Virga, M. Jason Hatfield, Philip M. Potter, Richard E. Lee, and Mary K. Danks
Mol Cancer Ther 2006 5: 1577-1584 doi: 10.1158/1535-7163.MCT-06-0090 [Abstract] [Full Text] [PDF]  

Chemotherapy and chemosensitization of non–small cell lung cancer with a novel immunomodulatory oligonucleotide targeting Toll-like receptor 9

Hui Wang, Elizabeth R. Rayburn, Wei Wang, Ekambar R. Kandimalla, Sudhir Agrawal, and Ruiwen Zhang
Mol Cancer Ther 2006 5: 1585-1592 doi: 10.1158/1535-7163.MCT-06-0094 [Abstract] [Full Text] [PDF]  

B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells

Rita Nahta, Linda X.H. Yuan, Derek J. Fiterman, Li Zhang, W. Fraser Symmans, Naoto T. Ueno, and Francisco J. Esteva
Mol Cancer Ther 2006 5: 1593-1601 doi: 10.1158/1535-7163.MCT-06-0133 [Abstract] [Full Text] [PDF]  

Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling

Stéphanie Arnould, Victoria J. Spanswick, Janet S. Macpherson, John A. Hartley, David E. Thurston, Duncan I. Jodrell, and Sylvie M. Guichard
Mol Cancer Ther 2006 5: 1602-1609 doi: 10.1158/1535-7163.MCT-06-0018 [Abstract] [Full Text] [PDF]  

Suicide cancer gene therapy using pore-forming toxin, streptolysin O

Wan Seok Yang, Sue-O Park, A-Rum Yoon, Ji Young Yoo, Min Kyung Kim, Chae-Ok Yun, and Chul-Woo Kim
Mol Cancer Ther 2006 5: 1610-1619 doi: 10.1158/1535-7163.MCT-05-0515 [Abstract] [Full Text] [PDF]  

Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery

Philippe Martinive, Julie De Wever, Caroline Bouzin, Christine Baudelet, Pierre Sonveaux, Vincent Grégoire, Bernard Gallez, and Olivier Feron
Mol Cancer Ther 2006 5: 1620-1627 doi: 10.1158/1535-7163.MCT-05-0472 [Abstract] [Full Text] [PDF]  

Research Articles: Development:

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors

Nicola F. Smith, Angela Hayes, Karen James, Bernard P. Nutley, Edward McDonald, Alan Henley, Brian Dymock, Martin J. Drysdale, Florence I. Raynaud, and Paul Workman
Mol Cancer Ther 2006 5: 1628-1637 doi: 10.1158/1535-7163.MCT-06-0041 [Abstract] [Full Text] [PDF]  

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