Drug Development Series: Review:

Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer

Antonio Jimeno and Manuel Hidalgo
Mol Cancer Ther 2006 5: 787-796 doi: 10.1158/1535-7163.MCT-06-0005 [Abstract] [Full Text] [PDF]  

Review:

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

Sonoko Masuda and Glenville Jones
Mol Cancer Ther 2006 5: 797-808 doi: 10.1158/1535-7163.MCT-05-0539 [Abstract] [Full Text] [PDF]  

Research Articles: Targets:

Molecular alterations after Polo-like kinase 1 mRNA suppression versus pharmacologic inhibition in cancer cells

Mathias Schmidt, Hans-Peter Hofmann, Karl Sanders, Georg Sczakiel, Thomas L. Beckers, and Volker Gekeler
Mol Cancer Ther 2006 5: 809-817 doi: 10.1158/1535-7163.MCT-05-0455 [Abstract] [Full Text] [PDF]  

Intracellular uptake and intracavitary targeting of folate-conjugated liposomes in a mouse lymphoma model with up-regulated folate receptors

Hilary Shmeeda, Lidia Mak, Dina Tzemach, Peleg Astrahan, Mark Tarshish, and Alberto Gabizon
Mol Cancer Ther 2006 5: 818-824 doi: 10.1158/1535-7163.MCT-05-0543 [Abstract] [Full Text] [PDF]  

Interleukin-12-deficient mice are at greater risk of UV radiation–induced skin tumors and malignant transformation of papillomas to carcinomas

Syed M. Meeran, Sudheer K. Mantena, Sreelatha Meleth, Craig A. Elmets, and Santosh K. Katiyar
Mol Cancer Ther 2006 5: 825-832 doi: 10.1158/1535-7163.MCT-06-0003 [Abstract] [Full Text] [PDF]  

Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma

Laura Rosanò, Francesca Spinella, Valeriana Di Castro, Shoukat Dedhar, Maria Rita Nicotra, Pier Giorgio Natali, and Anna Bagnato
Mol Cancer Ther 2006 5: 833-842 doi: 10.1158/1535-7163.MCT-05-0523 [Abstract] [Full Text] [PDF]  

Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft

Sanjeev Shukla and Sanjay Gupta
Mol Cancer Ther 2006 5: 843-852 doi: 10.1158/1535-7163.MCT-05-0370 [Abstract] [Full Text] [PDF]  

Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel

Kimberly J. Bussey, Koei Chin, Samir Lababidi, Mark Reimers, William C. Reinhold, Wen-Lin Kuo, Fuad Gwadry, Ajay, Hosein Kouros-Mehr, Jane Fridlyand, Ajay Jain, Colin Collins, Satoshi Nishizuka, Giovanni Tonon, Anna Roschke, Kristen Gehlhaus, Ilan Kirsch, Dominic A. Scudiero, Joe W. Gray, and John N. Weinstein
Mol Cancer Ther 2006 5: 853-867 doi: 10.1158/1535-7163.MCT-05-0155 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics:

Gene expression profiling of whole-blood samples from women exposed to hormone replacement therapy

Vanessa Dumeaux, Jostein Johansen, Anne-Lise Børresen-Dale, and Eiliv Lund
Mol Cancer Ther 2006 5: 868-876 doi: 10.1158/1535-7163.MCT-05-0329 [Abstract] [Full Text] [PDF] Supplementary Data  

A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein

Kazuyoshi Mutoh, Junko Mitsuhashi, Yasuhisa Kimura, Satomi Tsukahara, Etsuko Ishikawa, Kimie Sai, Shogo Ozawa, Jun-ichi Sawada, Kazumitsu Ueda, Kazuhiro Katayama, and Yoshikazu Sugimoto
Mol Cancer Ther 2006 5: 877-884 doi: 10.1158/1535-7163.MCT-05-0240 [Abstract] [Full Text] [PDF]  

Effect of combined DNA repair inhibition and G₂ checkpoint inhibition on cell cycle progression after DNA damage

Christopher M. Sturgeon, Zachary A. Knight, Kevan M. Shokat, and Michel Roberge
Mol Cancer Ther 2006 5: 885-892 doi: 10.1158/1535-7163.MCT-05-0358 [Abstract] [Full Text] [PDF]  

Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence

Tao Yan, Yuji Seo, Jane E. Schupp, Xuehuo Zeng, Anand B. Desai, and Timothy J. Kinsella
Mol Cancer Ther 2006 5: 893-902 doi: 10.1158/1535-7163.MCT-05-0364 [Abstract] [Full Text] [PDF]  

Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3

Baoguang Han, Han Xie, Qun Chen, and Jian-Ting Zhang
Mol Cancer Ther 2006 5: 903-912 doi: 10.1158/1535-7163.MCT-05-0393 [Abstract] [Full Text] [PDF]  

Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer

Jae Yeon Chun, Nagalakshmi Nadiminty, Soo Ok Lee, Sergio A. Onate, Wei Lou, and Allen C. Gao
Mol Cancer Ther 2006 5: 913-918 doi: 10.1158/1535-7163.MCT-05-0389 [Abstract] [Full Text] [PDF]  

Efficacy of a nitric oxide–releasing nonsteroidal anti-inflammatory drug and cytotoxic drugs in human colon cancer cell lines in vitro and xenografts

Carlo Leonetti, Marco Scarsella, Gabriella Zupi, Wainer Zoli, Dino Amadori, Laura Medri, Francesco Fabbri, Marco Rosetti, Paola Ulivi, Lorenzo Cecconetto, Manlio Bolla, and Anna Tesei
Mol Cancer Ther 2006 5: 919-926 doi: 10.1158/1535-7163.MCT-05-0536 [Abstract] [Full Text] [PDF]  

Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells

Ewa Sikora, Anna Bielak-Zmijewska, Adriana Magalska, Katarzyna Piwocka, Grazyna Mosieniak, Magdalena Kalinowska, Piotr Widlak, Iwona A. Cymerman, and Janusz M. Bujnicki
Mol Cancer Ther 2006 5: 927-934 doi: 10.1158/1535-7163.MCT-05-0360 [Abstract] [Full Text] [PDF]  

Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract

Li Tang, Yuesheng Zhang, Hillary E. Jobson, Jun Li, Katherine K. Stephenson, Kristina L. Wade, and Jed W. Fahey
Mol Cancer Ther 2006 5: 935-944 doi: 10.1158/1535-7163.MCT-05-0476 [Abstract] [Full Text] [PDF]  

The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor–related apoptosis-inducing ligand

Mano Horinaka, Tatsushi Yoshida, Takumi Shiraishi, Susumu Nakata, Miki Wakada, and Toshiyuki Sakai
Mol Cancer Ther 2006 5: 945-951 doi: 10.1158/1535-7163.MCT-05-0431 [Abstract] [Full Text] [PDF]  

Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway

Deborah Chirnomas, Toshiyasu Taniguchi, Michelle de la Vega, Ami P. Vaidya, Maria Vasserman, Anne-Renee Hartman, Richard Kennedy, Rosemary Foster, Jennifer Mahoney, Michael V. Seiden, and Alan D. D'Andrea
Mol Cancer Ther 2006 5: 952-961 doi: 10.1158/1535-7163.MCT-05-0493 [Abstract] [Full Text] [PDF]  

Potent antitumor activity of 10-methoxy-9-nitrocamptothecin

Peihua Luo, Qiaojun He, Xungui He, Yongzhou Hu, Wei Lu, Yiyu Cheng, and Bo Yang
Mol Cancer Ther 2006 5: 962-968 doi: 10.1158/1535-7163.MCT-05-0385 [Abstract] [Full Text] [PDF]  

Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine

Kimiko Ishiguro, Helen A. Seow, Philip G. Penketh, Krishnamurthy Shyam, and Alan C. Sartorelli
Mol Cancer Ther 2006 5: 969-976 doi: 10.1158/1535-7163.MCT-05-0532 [Abstract] [Full Text] [PDF]  

DNA adducts formed by a novel antitumor agent 11ß-dichloro in vitro and in vivo

Shawn M. Hillier, John C. Marquis, Beatriz Zayas, John S. Wishnok, Rosa G. Liberman, Paul L. Skipper, Steven R. Tannenbaum, John M. Essigmann, and Robert G. Croy
Mol Cancer Ther 2006 5: 977-984 doi: 10.1158/1535-7163.MCT-05-0464 [Abstract] [Full Text] [PDF]  

Construction of a novel DNA decoy that inhibits the oncogenic ß-catenin/T-cell factor pathway

Yosuke Seki, Hirofumi Yamamoto, Chew Yee Ngan, Masayoshi Yasui, Naruya Tomita, Kotaro Kitani, Ichiro Takemasa, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Chris Albanese, Yasufumi Kaneda, Richard G. Pestell, and Morito Monden
Mol Cancer Ther 2006 5: 985-994 doi: 10.1158/1535-7163.MCT-05-0388 [Abstract] [Full Text] [PDF]  

Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor

Daniel H. Albert, Paul Tapang, Terrance J. Magoc, Lori J. Pease, David R. Reuter, Ru-Qi Wei, Junling Li, Jun Guo, Peter F. Bousquet, Nayereh S. Ghoreishi-Haack, Baole Wang, Gail T. Bukofzer, Yi-Chun Wang, Jason A. Stavropoulos, Kresna Hartandi, Amanda L. Niquette, Nirupama Soni, Eric F. Johnson, J. Owen McCall, Jennifer J. Bouska, Yanping Luo, Cherrie K. Donawho, Yujia Dai, Patrick A. Marcotte, Keith B. Glaser, Michael R. Michaelides, and Steven K. Davidsen
Mol Cancer Ther 2006 5: 995-1006 doi: 10.1158/1535-7163.MCT-05-0410 [Abstract] [Full Text] [PDF]  

Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors

Jun Guo, Patrick A. Marcotte, J. Owen McCall, Yujia Dai, Lori J. Pease, Michael R. Michaelides, Steven K. Davidsen, and Keith B. Glaser
Mol Cancer Ther 2006 5: 1007-1013 doi: 10.1158/1535-7163.MCT-05-0359 [Abstract] [Full Text] [PDF]  

Enhancement of tumor thermal therapy using gold nanoparticle–assisted tumor necrosis factor- delivery

Rachana K. Visaria, Robert J. Griffin, Brent W. Williams, Emad S. Ebbini, Giulio F. Paciotti, Chang W. Song, and John C. Bischof
Mol Cancer Ther 2006 5: 1014-1020 doi: 10.1158/1535-7163.MCT-05-0381 [Abstract] [Full Text] [PDF]  

Targeted chemotherapy against intraperitoneally disseminated colon carcinoma using a cationized gelatin–conjugated HVJ envelope vector

Hidetoshi Mima, Seiji Yamamoto, Makoto Ito, Ryuji Tomoshige, Yasuhiko Tabata, Katsuto Tamai, and Yasufumi Kaneda
Mol Cancer Ther 2006 5: 1021-1028 doi: 10.1158/1535-7163.MCT-05-0352 [Abstract] [Full Text] [PDF]  

Cytokines fused to antibodies and their combinations as therapeutic agents against different peritoneal HER2/neu expressing tumors

Gustavo Helguera, José A. Rodríguez, and Manuel L. Penichet
Mol Cancer Ther 2006 5: 1029-1040 doi: 10.1158/1535-7163.MCT-05-0488 [Abstract] [Full Text] [PDF] Supplementary Data  

Aerosol delivery of urocanic acid–modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice

Hua Jin, Tae Hee Kim, Soon-Kyung Hwang, Seung-Hee Chang, Hyun Woo Kim, Hanjo K. Anderson, Han-Woong Lee, Kee-Ho Lee, Nancy H. Colburn, Hsin-Sheng Yang, Myung-Haing Cho, and Chong Su Cho
Mol Cancer Ther 2006 5: 1041-1049 doi: 10.1158/1535-7163.MCT-05-0433 [Abstract] [Full Text] [PDF]  

AMP-activated protein kinase protects against anti–epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death

Yvonne Andersson, Hang Le, Siri Juell, and Øystein Fodstad
Mol Cancer Ther 2006 5: 1050-1059 doi: 10.1158/1535-7163.MCT-05-0318 [Abstract] [Full Text] [PDF]  

Research Articles: Development:

Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide

Yian Wang, Ruisheng Yao, Anna Maciag, Clinton J. Grubbs, Ronald A. Lubet, and Ming You
Mol Cancer Ther 2006 5: 1060-1072 doi: 10.1158/1535-7163.MCT-05-0322 [Abstract] [Full Text] [PDF]  

Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations

Ronald A. Lubet, Konstantin Christov, Ming You, Ruisheng Yao, Vernon E. Steele, David W. End, M. Margaret Juliana, and Clinton J. Grubbs
Mol Cancer Ther 2006 5: 1073-1078 doi: 10.1158/1535-7163.MCT-05-0398 [Abstract] [Full Text] [PDF]  

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth

Karissa L. Gable, Betty A. Maddux, Cristina Penaranda, Marianna Zavodovskaya, Michael J. Campbell, Margaret Lobo, Louise Robinson, Steven Schow, John A. Kerner, Ira D. Goldfine, and Jack F. Youngren
Mol Cancer Ther 2006 5: 1079-1086 doi: 10.1158/1535-7163.MCT-05-0397 [Abstract] [Full Text] [PDF]  

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