Editorials:

Introducing the drug development series

Daniel D. Von Hoff
Mol Cancer Ther 2006 5: 477 doi: 10.1158/1535-7163.MCT-ednote [Full Text] [PDF]  

Review:

Targeted therapy by disabling crossroad signaling networks: the survivin paradigm

Dario C. Altieri
Mol Cancer Ther 2006 5: 478-482 doi: 10.1158/1535-7163.MCT-05-0436 [Abstract] [Full Text] [PDF]  

Articles:

Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells

Zhiwei Wang, Yuxiang Zhang, Yiwei Li, Sanjeev Banerjee, Joshua Liao, and Fazlul H. Sarkar
Mol Cancer Ther 2006 5: 483-493 doi: 10.1158/1535-7163.MCT-05-0299 [Abstract] [Full Text] [PDF]  

Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis

Xuesong Liu, Yan Shi, Vincent L. Giranda, and Yan Luo
Mol Cancer Ther 2006 5: 494-501 doi: 10.1158/1535-7163.MCT-05-0049 [Abstract] [Full Text] [PDF]  

Novel missense mutation of the DNA topoisomerase I gene in SN-38-resistant DLD-1 cells

Yasuhiro Arakawa, Hideaki Suzuki, Shinobu Saito, and Hisashi Yamada
Mol Cancer Ther 2006 5: 502-508 doi: 10.1158/1535-7163.MCT-05-0246 [Abstract] [Full Text] [PDF]  

Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3

Denis Lane, Marceline Côté, Roxanne Grondin, Marie-Christine Couture, and Alain Piché
Mol Cancer Ther 2006 5: 509-521 doi: 10.1158/1535-7163.MCT-05-0362 [Abstract] [Full Text] [PDF]  

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

Sharon Sanderson, Melanie Valenti, Sharon Gowan, Lisa Patterson, Zahida Ahmad, Paul Workman, and Suzanne A. Eccles
Mol Cancer Ther 2006 5: 522-532 doi: 10.1158/1535-7163.MCT-05-0439 [Abstract] [Full Text] [PDF]  

SUMOylation plays a role in gemcitabine- and bortezomib-induced cytotoxicity in human oropharyngeal carcinoma KB gemcitabine-resistant clone

Vincent Chung, Bingsen Zhou, Xiyong Liu, Lijun Zhu, Lee M. Boo, Ha-Van Nguyen, David K. Ann, Jing Song, Yuan Chen, and Yun Yen
Mol Cancer Ther 2006 5: 533-540 doi: 10.1158/1535-7163.MCT-05-0290 [Abstract] [Full Text] [PDF]  

Enhanced antitumor activity of P450 prodrug-based gene therapy using the low K_m cyclophosphamide 4-hydroxylase P450 2B11

Youssef Jounaidi, Chong-Sheng Chen, Gareth J. Veal, and David J. Waxman
Mol Cancer Ther 2006 5: 541-555 doi: 10.1158/1535-7163.MCT-05-0321 [Abstract] [Full Text] [PDF]  

Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane

John A. Savino, III, Jodi F. Evans, Dorianne Rabinowitz, Karen J. Auborn, and Timothy H. Carter
Mol Cancer Ther 2006 5: 556-563 doi: 10.1158/1535-7163.MCT-05-0355 [Abstract] [Full Text] [PDF]  

Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis

Georges Noël, Camille Godon, Marie Fernet, Nicole Giocanti, Frédérique Mégnin-Chanet, and Vincent Favaudon
Mol Cancer Ther 2006 5: 564-574 doi: 10.1158/1535-7163.MCT-05-0418 [Abstract] [Full Text] [PDF]  

Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention

Elisabeth Bertl, Helmut Bartsch, and Clarissa Gerhäuser
Mol Cancer Ther 2006 5: 575-585 doi: 10.1158/1535-7163.MCT-05-0324 [Abstract] [Full Text] [PDF]  

A Ferrous-triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase

Jimin Shao, Bingsen Zhou, Angel J. Di Bilio, Lijun Zhu, Tieli Wang, Christina Qi, Jennifer Shih, and Yun Yen
Mol Cancer Ther 2006 5: 586-592 doi: 10.1158/1535-7163.MCT-05-0384 [Abstract] [Full Text] [PDF]  

PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy

Anne-Jan Dijkhuis, Karin Klappe, Susan Jacobs, Bart-Jan Kroesen, Willem Kamps, Hannie Sietsma, and Jan Willem Kok
Mol Cancer Ther 2006 5: 593-601 doi: 10.1158/1535-7163.MCT-05-0457 [Abstract] [Full Text] [PDF]  

Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes

Matthew C. Tuthill, Carolyn E. Oki, and Patricia S. Lorenzo
Mol Cancer Ther 2006 5: 602-610 doi: 10.1158/1535-7163.MCT-05-0317 [Abstract] [Full Text] [PDF]  

Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells

Mariya Farooqui, Zhen H. Geng, Elliot J. Stephenson, Nurulain Zaveri, Douglas Yee, and Kalpna Gupta
Mol Cancer Ther 2006 5: 611-620 doi: 10.1158/1535-7163.MCT-05-0016 [Abstract] [Full Text] [PDF]  

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S. Zervos, Bradford Carter, James Turkson, and Richard Jove
Mol Cancer Ther 2006 5: 621-629 doi: 10.1158/1535-7163.MCT-05-0268 [Abstract] [Full Text] [PDF]  

Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase

Garth Powis, Peter Wipf, Stephen M. Lynch, Anne Birmingham, and D. Lynn Kirkpatrick
Mol Cancer Ther 2006 5: 630-636 doi: 10.1158/1535-7163.MCT-05-0487 [Abstract] [Full Text] [PDF]  

Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma

Dimpy Koul, Ruijun Shen, Sherry Bergh, Xiaoyang Sheng, Shishir Shishodia, Tiffany A. Lafortune, Yiling Lu, John F. de Groot, Gordon B. Mills, and W.K. Alfred Yung
Mol Cancer Ther 2006 5: 637-644 doi: 10.1158/1535-7163.MCT-05-0453 [Abstract] [Full Text] [PDF]  

Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells

Lincoln A. Edwards, Maite Verreault, Brian Thiessen, Wieslawa H. Dragowska, Yanping Hu, Juliana H.F. Yeung, Shoukat Dedhar, and Marcel B. Bally
Mol Cancer Ther 2006 5: 645-654 doi: 10.1158/1535-7163.MCT-05-0099 [Abstract] [Full Text] [PDF]  

The cellular phenotype of AZ703, a novel selective imidazo[1,2-a]pyridine cyclin-dependent kinase inhibitor

Kate F. Byth, Catherine Geh, Cheryl L. Forder, Sandra E. Oakes, and Andrew P. Thomas
Mol Cancer Ther 2006 5: 655-664 doi: 10.1158/1535-7163.MCT-05-0205 [Abstract] [Full Text] [PDF]  

Differential cellular and molecular effects of bortezomib, a proteasome inhibitor, in human breast cancer cells

Jordi Codony-Servat, Maria A. Tapia, Marta Bosch, Cristina Oliva, Josep Domingo-Domenech, Begoña Mellado, Mark Rolfe, Jeffrey S. Ross, Pere Gascon, Ana Rovira, and Joan Albanell
Mol Cancer Ther 2006 5: 665-675 doi: 10.1158/1535-7163.MCT-05-0147 [Abstract] [Full Text] [PDF]  

Combination therapy of androgen-independent prostate cancer using a prostate restricted replicative adenovirus and a replication-defective adenovirus encoding human endostatin-angiostatin fusion gene

Xiong Li, Sudhanshu P. Raikwar, You-Hong Liu, Sang-Jin Lee, Yan-Ping Zhang, Shaobo Zhang, Liang Cheng, Sang-Don Lee, Beth Elisa Juliar, Thomas A. Gardner, Meei-Huey Jeng, and Chinghai Kao
Mol Cancer Ther 2006 5: 676-684 doi: 10.1158/1535-7163.MCT-05-0339 [Abstract] [Full Text] [PDF]  

The antitumor effect of LJ-529, a novel agonist to A3 adenosine receptor, in both estrogen receptor–positive and estrogen receptor–negative human breast cancers

Heekyoung Chung, Ji-Youn Jung, Sung-Dae Cho, Kyung-A Hong, Hyun-Jun Kim, Dong-Hui Shin, Hwan Kim, Hea Ok Kim, Dae Hong Shin, Hyuk Woo Lee, Lak Shin Jeong, and Gu Kong
Mol Cancer Ther 2006 5: 685-692 doi: 10.1158/1535-7163.MCT-05-0245 [Abstract] [Full Text] [PDF]  

Survivin and Granzyme B–induced apoptosis, a novel anticancer therapy

Hugo Caldas, Florinda O. Jaynes, Michael W. Boyer, Sue Hammond, and Rachel A. Altura
Mol Cancer Ther 2006 5: 693-703 doi: 10.1158/1535-7163.MCT-05-0423 [Abstract] [Full Text] [PDF]  

NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-B signal pathway

Taeko Okudaira, Mariko Tomita, Jun-Nosuke Uchihara, Takehiro Matsuda, Chie Ishikawa, Hirochika Kawakami, Masato Masuda, Yuetsu Tanaka, Kazuiku Ohshiro, Nobuyuki Takasu, and Naoki Mori
Mol Cancer Ther 2006 5: 704-712 doi: 10.1158/1535-7163.MCT-05-0434 [Abstract] [Full Text] [PDF]  

Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt

Joell J. Gills, Susan Holbeck, Melinda Hollingshead, Stephen M. Hewitt, Alan P. Kozikowski, and Phillip A. Dennis
Mol Cancer Ther 2006 5: 713-722 doi: 10.1158/1535-7163.MCT-05-0484 [Abstract] [Full Text] [PDF]  

Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells

Ruoping Tang, Anne-Marie Faussat, Patricia Majdak, Christophe Marzac, Sabine Dubrulle, Zora Marjanovic, Ollivier Legrand, and Jean-Pierre Marie
Mol Cancer Ther 2006 5: 723-731 doi: 10.1158/1535-7163.MCT-05-0164 [Abstract] [Full Text] [PDF]  

Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O⁶-benzylguanine

Tomio Ueno, Sae Hee Ko, Elizabeth Grubbs, Yasunori Yoshimoto, Christi Augustine, Zeinab Abdel-Wahab, Tsung-Yen Cheng, Omar I. Abdel-Wahab, Scott K. Pruitt, Henry S. Friedman, and Douglas S. Tyler
Mol Cancer Ther 2006 5: 732-738 doi: 10.1158/1535-7163.MCT-05-0098 [Abstract] [Full Text] [PDF]  

Identification of a small topoisomerase I–binding peptide that has synergistic antitumor activity with 9-aminocamptothecin

Christopher D. Pond, Kathryn M. Marshall, and Louis R. Barrows
Mol Cancer Ther 2006 5: 739-745 doi: 10.1158/1535-7163.MCT-05-0377 [Abstract] [Full Text] [PDF]  

Sulindac independently modulates extracellular signal–regulated kinase 1/2 and cyclic GMP–dependent protein kinase signaling pathways

Pamela L. Rice, Stevany L. Peters, K. Scott Beard, and Dennis J. Ahnen
Mol Cancer Ther 2006 5: 746-754 doi: 10.1158/1535-7163.MCT-05-0210 [Abstract] [Full Text] [PDF]  

Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses

Svetlana Komarova, Yosuke Kawakami, Mariam A. Stoff-Khalili, David T. Curiel, and Larisa Pereboeva
Mol Cancer Ther 2006 5: 755-766 doi: 10.1158/1535-7163.MCT-05-0334 [Abstract] [Full Text] [PDF]  

Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers

Masaaki Komatsu, Keiko Hiyama, Keiji Tanimoto, Mayu Yunokawa, Keiko Otani, Megu Ohtaki, Eiso Hiyama, Junzo Kigawa, Michitaka Ohwada, Mitsuaki Suzuki, Nobutaka Nagai, Yoshiki Kudo, and Masahiko Nishiyama
Mol Cancer Ther 2006 5: 767-775 doi: 10.1158/1535-7163.MCT-05-0408 [Abstract] [Full Text] [PDF] Supplementary Material  

Low doses of cisplatin or gemcitabine plus Photofrin/photodynamic therapy: Disjointed cell cycle phase-related activity accounts for synergistic outcome in metastatic non–small cell lung cancer cells (H1299)

Elvira Crescenzi, Angela Chiaviello, Gianfranco Canti, Elena Reddi, Bianca Maria Veneziani, and Giuseppe Palumbo
Mol Cancer Ther 2006 5: 776-785 doi: 10.1158/1535-7163.MCT-05-0425 [Abstract] [Full Text] [PDF]  

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