Reviews:

Tumor models for efficacy determination

Beverly A. Teicher
Mol Cancer Ther 2006 5: 2435-2443 doi: 10.1158/1535-7163.MCT-06-0391 [Abstract] [Full Text] [PDF]  

Developing gene expression signatures of pathway deregulation in tumors

James W. Watters and Christopher J. Roberts
Mol Cancer Ther 2006 5: 2444-2449 doi: 10.1158/1535-7163.MCT-06-0340 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells

Steven L. Warner, Ruben M. Munoz, Phillip Stafford, Erich Koller, Laurence H. Hurley, Daniel D. Von Hoff, and Haiyong Han
Mol Cancer Ther 2006 5: 2450-2458 doi: 10.1158/1535-7163.MCT-06-0202 [Abstract] [Full Text] [PDF]  

Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor

Jennifer A. Seamon, Catherine A. Rugg, Stuart Emanuel, Anna Maria Calcagno, Suresh V. Ambudkar, Steven A. Middleton, Jeannene Butler, Virna Borowski, and Lee M. Greenberger
Mol Cancer Ther 2006 5: 2459-2467 doi: 10.1158/1535-7163.MCT-06-0339 [Abstract] [Full Text] [PDF]  

Differing effects of microtubule depolymerizing and stabilizing chemotherapeutic agents on t-SNARE–mediated apical targeting of prostate-specific membrane antigen

Jason J. Christiansen, Thomas Weimbs, Neil Bander, and Ayyappan K. Rajasekaran
Mol Cancer Ther 2006 5: 2468-2473 doi: 10.1158/1535-7163.MCT-06-0253 [Abstract] [Full Text] [PDF]  

Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions

Jinhai Wang, Liusheng He, Christian A. Combs, Gregory Roderiquez, and Michael A. Norcross
Mol Cancer Ther 2006 5: 2474-2483 doi: 10.1158/1535-7163.MCT-05-0261 [Abstract] [Full Text] [PDF]  

Inhibition of cell growth and nuclear factor-B activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503

Her-Shyong Shiah, Wenli Gao, David C. Baker, and Yung-Chi Cheng
Mol Cancer Ther 2006 5: 2484-2493 doi: 10.1158/1535-7163.MCT-06-0146 [Abstract] [Full Text] [PDF]  

Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenografts

Diana C. Birle and David W. Hedley
Mol Cancer Ther 2006 5: 2494-2502 doi: 10.1158/1535-7163.MCT-05-0504 [Abstract] [Full Text] [PDF]  

Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth

María V. Lopez, Patricia Blanco, Diego L. Viale, Eduardo G. Cafferata, Cecilia Carbone, David Gould, Yuti Chernajovsky, and Osvaldo L. Podhajcer
Mol Cancer Ther 2006 5: 2503-2511 doi: 10.1158/1535-7163.MCT-06-0286 [Abstract] [Full Text] [PDF] Supplementary Material  

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

Raoul Tibes, YiHua Qiu, Yiling Lu, Bryan Hennessy, Michael Andreeff, Gordon B. Mills, and Steven M. Kornblau
Mol Cancer Ther 2006 5: 2512-2521 doi: 10.1158/1535-7163.MCT-06-0334 [Abstract] [Full Text] [PDF]  

The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling

Takayuki Ikezoe, Chie Nishioka, Taizo Tasaka, Yang Yang, Naoki Komatsu, Kazuto Togitani, H. Phillip Koeffler, and Hirokuni Taguchi
Mol Cancer Ther 2006 5: 2522-2530 doi: 10.1158/1535-7163.MCT-06-0071 [Abstract] [Full Text] [PDF]  

Quantitative analysis of O⁶-alkylguanine-DNA alkyltransferase in malignant glioma

Jill A. Maxwell, Stewart P. Johnson, Jennifer A. Quinn, Roger E. McLendon, Francis Ali-Osman, Allan H. Friedman, James E. Herndon, II, Katja Bierau, Joseph Bigley, Darell D. Bigner, and Henry S. Friedman
Mol Cancer Ther 2006 5: 2531-2539 doi: 10.1158/1535-7163.MCT-06-0106 [Abstract] [Full Text] [PDF]  

The mechanism of methylselenocysteine and docetaxel synergistic activity in prostate cancer cells

Rami G. Azrak, Cheryl L. Frank, Xiang Ling, Harry K. Slocum, Fengzhi Li, Barbara A. Foster, and Youcef M. Rustum
Mol Cancer Ther 2006 5: 2540-2548 doi: 10.1158/1535-7163.MCT-05-0546 [Abstract] [Full Text] [PDF]  

The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity

Shrikanta Chattopadhyay, Rongbao Zhao, Eugenia Tsai, Vern L. Schramm, and I. David Goldman
Mol Cancer Ther 2006 5: 2549-2555 doi: 10.1158/1535-7163.MCT-06-0313 [Abstract] [Full Text] [PDF]  

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

Ralph J. Abi-Habib, Ravibhushan Singh, Shihui Liu, Thomas H. Bugge, Stephen H. Leppla, and Arthur E. Frankel
Mol Cancer Ther 2006 5: 2556-2562 doi: 10.1158/1535-7163.MCT-06-0315 [Abstract] [Full Text] [PDF]  

Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer

Hisatsugu Ohori, Hiroyuki Yamakoshi, Masaki Tomizawa, Masatoshi Shibuya, Yuichi Kakudo, Atsuko Takahashi, Shin Takahashi, Satoshi Kato, Takao Suzuki, Chikashi Ishioka, Yoshiharu Iwabuchi, and Hiroyuki Shibata
Mol Cancer Ther 2006 5: 2563-2571 doi: 10.1158/1535-7163.MCT-06-0174 [Abstract] [Full Text] [PDF] Supplementary Data  

Correction for chromosome-17 is critical for the determination of true Her-2/neu gene amplification status in breast cancer

Lissandra Dal Lago, Virginie Durbecq, Christine Desmedt, Roberto Salgado, Thibault Verjat, Laurence Lespagnard, Yan Ma, Isabelle Veys, Angelo Di Leo, Christos Sotiriou, Martine Piccart, and Denis Larsimont
Mol Cancer Ther 2006 5: 2572-2579 doi: 10.1158/1535-7163.MCT-06-0129 [Abstract] [Full Text] [PDF] Supplementary Data  

Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint

Gregory M. Chin and Ronald Herbst
Mol Cancer Ther 2006 5: 2580-2591 doi: 10.1158/1535-7163.MCT-06-0201 [Abstract] [Full Text] [PDF] Supplementary Data  

Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases

Chih-hung Lee, Takashi Kakinuma, Julia Wang, Hong Zhang, Douglas C. Palmer, Nicholas P. Restifo, and Sam T. Hwang
Mol Cancer Ther 2006 5: 2592-2599 doi: 10.1158/1535-7163.MCT-06-0310 [Abstract] [Full Text] [PDF]  

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