Articles:

AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model

I-Fen Chen, Fu Ou-Yang, Jen-Yu Hung, Jaw-Ching Liu, Hongying Wang, Shao-Chun Wang, Ming-Feng Hou, Gabriel N. Hortobagyi, and Mien-Chie Hung
Mol Cancer Ther 2006 5: 1-7 doi: 10.1158/1535-7163.MCT-05-0310 [Abstract] [Full Text] [PDF]  

Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas

Tin Lap Lee, Jason Yeh, Carter Van Waes, and Zhong Chen
Mol Cancer Ther 2006 5: 8-19 doi: 10.1158/1535-7163.MCT-05-0069 [Abstract] [Full Text] [PDF]  

Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide

Patrick B. Senatus, Yin Li, Christopher Mandigo, Gwen Nichols, Gaetan Moise, Yuehua Mao, Melandee D. Brown, Richard C. Anderson, Andrew T. Parsa, Paul W. Brandt-Rauf, Jeffrey N. Bruce, and Robert L. Fine
Mol Cancer Ther 2006 5: 20-28 doi: 10.1158/1535-7163.MCT-05-0181 [Abstract] [Full Text] [PDF]  

Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons

Hiroshi Y. Yamada and Gary J. Gorbsky
Mol Cancer Ther 2006 5: 29-38 doi: 10.1158/1535-7163.MCT-05-0126 [Abstract] [Full Text] [PDF]  

Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

Guoxiang Shen, Changjiang Xu, Rong Hu, Mohit R. Jain, Avantika Gopalkrishnan, Sujit Nair, Mou-Tuan Huang, Jefferson Y. Chan, and Ah-Ng Tony Kong
Mol Cancer Ther 2006 5: 39-51 doi: 10.1158/1535-7163.MCT-05-0293 [Abstract] [Full Text] [PDF]  

Targeted delivery of methotrexate to epidermal growth factor receptor–positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates

Gong Wu, Rolf F. Barth, Weilian Yang, Shinji Kawabata, Liwen Zhang, and Kari Green-Church
Mol Cancer Ther 2006 5: 52-59 doi: 10.1158/1535-7163.MCT-05-0325 [Abstract] [Full Text] [PDF]  

The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization

Danhua Xiao, Atsuko Deguchi, Gregg G. Gundersen, Bert Oehlen, Lee Arnold, and I. Bernard Weinstein
Mol Cancer Ther 2006 5: 60-67 doi: 10.1158/1535-7163.MCT-05-0260 [Abstract] [Full Text] [PDF]  

Enhancement of DNA topoisomerase I inhibitor–induced apoptosis by ursodeoxycholic acid

Tadashi Ikegami, Yasushi Matsuzaki, Maryam Al Rashid, Susan Ceryak, Yining Zhang, and Bernard Bouscarel
Mol Cancer Ther 2006 5: 68-79 doi: 10.1158/1535-7163.MCT-05-0107 [Abstract] [Full Text] [PDF]  

Improvement by solid dispersion of the bioavailability of KRN633, a selective inhibitor of VEGF receptor-2 tyrosine kinase, and identification of its potential therapeutic window

Naoki Matsunaga, Kazuhide Nakamura, Atsushi Yamamoto, Eri Taguchi, Hiromi Tsunoda, and Kazumi Takahashi
Mol Cancer Ther 2006 5: 80-88 doi: 10.1158/1535-7163.MCT-05-0202 [Abstract] [Full Text] [PDF]  

Antitumor efficacy of a urokinase activation–dependent anthrax toxin

Birgitte Rønø, John Rømer, Shihui Liu, Thomas H. Bugge, Stephen H. Leppla, and Paul E.G. Kristjansen
Mol Cancer Ther 2006 5: 89-96 doi: 10.1158/1535-7163.MCT-05-0163 [Abstract] [Full Text] [PDF]  

New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution

Yoram Barak, Stephen H. Thorne, David F. Ackerley, Susan V. Lynch, Christopher H. Contag, and A. Matin
Mol Cancer Ther 2006 5: 97-103 doi: 10.1158/1535-7163.MCT-05-0365 [Abstract] [Full Text] [PDF]  

Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels

Robert Wild, Krista Fager, Christine Flefleh, David Kan, Ivan Inigo, Stephen Castaneda, Feng (Roger) Luo, Amy Camuso, Kelly McGlinchey, and William C. Rose
Mol Cancer Ther 2006 5: 104-113 doi: 10.1158/1535-7163.MCT-05-0259 [Abstract] [Full Text] [PDF]  

Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function

Yang Feng, Zhongyu Zhu, Xiaodong Xiao, Vidita Choudhry, J. Carl Barrett, and Dimiter S. Dimitrov
Mol Cancer Ther 2006 5: 114-120 doi: 10.1158/1535-7163.MCT-05-0252 [Abstract] [Full Text] [PDF]  

Differential competitive resistance to methylating versus chloroethylating agents among five O⁶-alkylguanine DNA alkyltransferases in human hematopoietic cells

Aparecida Maria Fontes, Brian M. Davis, Lance P. Encell, Karen Lingas, Dimas Tadeu Covas, Marco Antonio Zago, Lawrence A. Loeb, Anthony E. Pegg, and Stanton L. Gerson
Mol Cancer Ther 2006 5: 121-128 doi: 10.1158/1535-7163.MCT-05-0236 [Abstract] [Full Text] [PDF]  

Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells

Seiji Kondo, Noriko Tanaka, Satoshi Kubota, Yoshiki Mukudai, Gen Yosimichi, Toshio Sugahara, and Masaharu Takigawa
Mol Cancer Ther 2006 5: 129-137 doi: 10.1158/1535-7163.MCT-05-0097 [Abstract] [Full Text] [PDF]  

Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

Yean Kit Lee, Crescent R. Isham, Scott H. Kaufman, and Keith C. Bible
Mol Cancer Ther 2006 5: 138-148 doi: 10.1158/1535-7163.MCT-05-0235 [Abstract] [Full Text] [PDF]  

Antitumor efficacy of CD137 ligation is maximized by the use of a CD137 single-chain Fv–expressing whole-cell tumor vaccine compared with CD137-specific monoclonal antibody infusion

Hongtao Zhang, Keith L. Knutson, Karl Erik Hellstrom, Mary L. Disis, and Ingegerd Hellstrom
Mol Cancer Ther 2006 5: 149-155 doi: 10.1158/1535-7163.MCT-05-0206 [Abstract] [Full Text] [PDF]  

Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro

Karl Y. Hostetler, Steffney Rought, Kathy A. Aldern, Julissa Trahan, James R. Beadle, and Jacques Corbeil
Mol Cancer Ther 2006 5: 156-159 doi: 10.1158/1535-7163.MCT-05-0200 [Abstract] [Full Text] [PDF]  

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks, Robert R. Donatelli, Rose M. Tominovich, Louis V. LaFrance, Kristi A. Leonard, Joan M. Gushue, Daniel J. Parks, Raul R. Calvo, Karen L. Milkiewicz, Juan José Marugán, Pierre Raboisson, Maxwell D. Cummings, Bruce L. Grasberger, Dana L. Johnson, Tianbao Lu, Christopher J. Molloy, and Anna C. Maroney
Mol Cancer Ther 2006 5: 160-169 doi: 10.1158/1535-7163.MCT-05-0199 [Abstract] [Full Text] [PDF]  

Sensitization of TRAIL–resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin

Yulin Ma, Vijayabaskar Lakshmikanthan, Ronald W. Lewis, and M. Vijay Kumar
Mol Cancer Ther 2006 5: 170-178 doi: 10.1158/1535-7163.MCT-05-0129 [Abstract] [Full Text] [PDF]  

Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells

Francesco Paduano, Raffaella Villa, Marzia Pennati, Marco Folini, Mara Binda, Maria Grazia Daidone, and Nadia Zaffaroni
Mol Cancer Ther 2006 5: 179-186 doi: 10.1158/1535-7163.MCT-05-0132 [Abstract] [Full Text] [PDF]  

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

Mounia Beloueche-Babari, L. Elizabeth Jackson, Nada M.S. Al-Saffar, Suzanne A. Eccles, Florence I. Raynaud, Paul Workman, Martin O. Leach, and Sabrina M. Ronen
Mol Cancer Ther 2006 5: 187-196 doi: 10.1158/1535-7163.MCT-03-0220 [Abstract] [Full Text] [PDF]  

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